Prognostic Significance of Blood Marker of Hypertrophy– Cardiotrophin-1 When Carrying Different Variants of Its Gene in Men With Essential Hypertension

Матохнюк, М.О.; Limanskiy, Oleksandr V.; Maiko, О.V.; Zhebel, V. M.; Shevchuk, O.; Palii, Irina K.

doi:10.36740/wlek202102118

Cited by 4 publications

(4 citation statements)

References 8 publications

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“…A clinical study by M. O. Matokhniuk et al has revealed a correlation between plasma CT and LV myocardial mass index in the patients with heart failure [19]. The same result presented study by U. Polat et al can be used as a new biomarker and correlated with standard markers of myocardial ischemia [20].…”

Section: Original Researchmentioning

confidence: 57%

Left ventricular remodeling in normotensive Wistar rats exposed to intermittent hypoxia of different duration

Kolesnyk¹,

Kolesnyk²,

Hancheva

et al. 2023

Patologìâ

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Intermittent hypoxia has been studied for many years as a promising non-pharmacological method of cardiovascular disease prevention. Hypoxic effects are accompanied by structural and functional changes in the myocardium. There is a direct link between the duration of hypoxic exposures and the severity of left ventricular myocardial remodeling. A range of histochemical markers of myocardial remodeling (cardiotrophin-1, titin, collagen type 1, annexin V) characterizing parenchymal-stromal relationships in the myocardium has shown high informativeness and prognostic value. The aim of the study was to examine cardiotrophin-1, titin, collagen type 1, annexin V and the morphofunctional state of the left ventricle of the heart in experimental rats exposed to intermittent 15-day (IH15) and 60-day hypoxia (IH60). Materials and methods. Intermittent hypoxia was modeled using 30 normotensive male Wistar rats, 7–8 months old, which were randomly assigned to 3 experimental groups of 10 animals each: 1) INT – a control group – intact animals (196.3 ± 6.8 g); 2) IH15 – 15-day hypoxia (205.6 ± 4.1 g); 3) IH60 – 60-day hypoxia (201.1 ± 5.5 g). The study compared the effects of intermittent hypoxia of varying duration: 15-day and 60-day hypoxia. Experimental modeling of intermittent hypoxia of 2 terms revealed a number of differences between the effects dependent on this factor duration through functional (blood pressure measurement, echocardiography) and immunofluorescent studies. Results. Blood pressure in rats of both groups was in the normotensive range, but an increase in systolic by 10 % and diastolic by 19 % was found in IH60 group compared to IH15 group (p < 0.05). In IH15 group, there was a significant decrease in end-diastolic dimension by 20 %, end-systolic dimension by 22 %, an increase in the thickness of left ventricular posterior wall by 44 % and interventricular septum by 33 % as well as left ventricular mass by 12 %, indicating concentric remodeling of the left ventricle, the development of which was confirmed by a 76 % increase in relative wall thickness compared to that in the control group (p < 0.05). Along with these changes, a decrease in end-diastolic volume by 47 %, end-systolic volume by 48 %, stroke volume by 49 % and cardiac output by 50 % with preserved ejection fraction was revealed (p < 0.05). While the parameters of IH60 rats were characterized by an increase in the thickness of interventricular septum by 33 % and left ventricular posterior wall by 17 %, as well as left ventricle mass by 23 %, relative left ventricular wall thickness was 15 % higher than the control value (p < 0.05). At the same time, diastolic volume was 9 % decreased and systolic volume was 24 % increased (p < 0.05). Also, cardiac output was increased by 58 % compared to that in 15-day hypoxic rats with an 8 % decrease in ejection fraction (p < 0.05). The concentrations of markers in IH60 group exceeded those in IH15, namely: cardiotrophin-1 by 39 %, titin by 70 %, collagen type 1 by 60 % and annexin V by 130 % (p < 0.05). Conclusions. 15-day hypoxia forms concentric left ventricular hypertrophy according to echocardiography findings; the study of marker profile of myocardial remodeling has revealed the development of moderate hypertrophy with increased resilient-elastic properties and decreased intensity of cardiomyocyte death. Remodeling caused by 60-day hypoxia is characterized by the eccentric pattern of changes with severe hypertrophy, significant fibrosis associated with apoptosis of cardiomyocytes. Such morphofunctional state of the myocardium may indicate the initial stages of maladaptation, increasing the risk of heart failure development.

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Section: Original Researchmentioning

confidence: 57%

Left ventricular remodeling in normotensive Wistar rats exposed to intermittent hypoxia of different duration

Kolesnyk¹,

Kolesnyk²,

Hancheva

et al. 2023

Patologìâ

View full text Add to dashboard Cite

show abstract

“…In patients with LVH and heart failure mediated by hypertension, the levels of CT-1 are increased, and plasma CT-1 level ≥122,895 pg/mL can be used for early diagnosis of changes in myocardial structure such as left ventricular hypertrophy, and plasma CT-1 levels ≥303.81 pg/mL for early detection of combined heart failure [33]. However, this study only included male patients and the sample was small.…”

Section: Cardiotrophinmentioning

confidence: 99%

Plasma Biomarkers for Hypertension-Mediated Organ Damage Detection: A Narrative Review

Liu,

Yang,

Lip

et al. 2024

Biomedicines

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Hypertension (HT) is a disease that poses a serious threat to human health, mediating organ damage such as the cardiovascular (CV) system, kidneys, central nervous system (CNS), and retinae, ultimately increasing the risk of death due to damage to the entire vascular system. Thus, the widespread prevalence of hypertension brings enormous health problems and socioeconomic burdens worldwide. The goal of hypertension management is to prevent the risk of hypertension-mediated organ damage and excess mortality of cardiovascular diseases. To achieve this goal, hypertension guidelines recommend accurate monitoring of blood pressure and assessment of associated target organ damage. Early identification of organ damage mediated by hypertension is therefore crucial. Plasma biomarkers as a non-invasive test can help identify patients with organ damage mediated by hypertension who will benefit from antihypertensive treatment optimization and improved prognosis. In this review, we provide an overview of some currently available, under-researched, potential plasma biomarkers of organ damage mediated by hypertension, looking for biomarkers that can be detected by simple testing to identify hypertensive patients with organ damage, which is of great significance in clinical work. Natriuretic peptides (NPs) can be utilized as a traditional biomarker to detect hypertension-mediated organ damage, especially for heart failure. Nevertheless, we additionally may need to combine two or more plasma biomarkers to monitor organ damage in the early stages of hypertension.

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“…Так, серед мешканців Подільського регіону України діагностичне та прогностичне значення мозкового (МНП) та судинного натрійуретичного пептидів (СНП) при поліморфізмі успадкування гена рецептора ангіотензину ІІ 1-го типу (АТ1Р) вивчали О. Л. Старжинська [17] у чоловіків; О. О. Сакович [16], С. В. Франчук [7] у жінок; у носіїв різних варіантів гена мозкового натрійуретичного пептиду -Ю. П. Пашкова [13] у чоловіків; Л. М. Сурсаєва [18] у жінок. Вплив поліморфізму гена альдостеронсинтетази (CYP11B2) на плазмовий рівень МНП досліджувала М. С. Лозинська [11], діагностичне та клінічне значення кардіотрофіну-1 у чоловіків при поліморфізмі кодуючого гена -М. О. Ма-тохнюк [12]. В. О. Ружанська [15] оцінила прогностичні та діагностичні можливості галектину-3 та МНП при поліморфізмі гена АТ1Р у чоловіків Подільського регіону.…”

Section: вступunclassified

Plasma levels of galectin-3 in residents of the Podillya region of Ukraine without signs of cardiovascular pathology carriers of different variants of the coding gene (LGALS-3, rs 2274273)

Polishchuk¹

2022

Rep. of Vinnytsia Nation. Med. Univ.

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Annotation. The purpose of the study is to investigate the plasma level of galectin-3 in postmenopausal women without signs of cardiovascular pathology and its possible association with the structural and functional parameters of the myocardium in carriers of different polymorphic variants of the coding gene (LGALS-3, rs2274273). 67 women of postmenopausal age (average age 56.43±0.64 years) without signs of cardiovascular pathology residents of the Podillya region of Ukraine were examined. In addition to the general clinical examination, the research used the enzyme immunoassay method to determine the level of galectin-3 in blood plasma, genotyping of the LGALS3 gene at the rs2274273 locus by means of polymerase chain reaction, and ultrasound of the heart. Statistical processing of the obtained results was carried out using the package of statistical programs SPSS, STATISTICA v. 10.0. By means of correlation analysis with the calculation of Spearman's rank correlation coefficients (r), an assessment of the possible association of the plasma level of the biomarker and the structural and functional indicators of the heart was carried out. The critical value of the significance level (p) was ≤0.05. In the examined population of women, there was no significant difference between the frequency of occurrence of the GA and GG genotypes carriers of the galectin-3 gene locus rs2274273: 49.25% (n=33) and 40.30% (n=27), respectively (p>0.05). The AA genotype variant was found in 10.45% (n=7) of individuals, which is significantly less frequent than both the GA and GG genotypes (p<0.01). The frequency of distribution of genotypes corresponded to the Hardy-Weinberg equilibrium. The average level of galletin-3 in blood plasma in women was 6.68±0.30 ng/ml, it was within the generally accepted norms and did not reliably differ from the corresponding indicators in men of the same region. No significant difference in plasma concentrations of galectin-3 was found in carriers of different polymorphic variants of the galectin-3 gene. Correlation between the level of galectin-3 in the blood plasma and most indicators of intracardiac and systemic hemodynamics in women without cardiovascular pathology was not found. In the future, it is planned to study the formation of prerequisites for chronic heart failure (CHF) in women with EH based on indicators of the plasma level of galectin-3 in carriers of polymorphic variants of the coding gene (LGALS-3, rs2274273).

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Prognostic Significance of Blood Marker of Hypertrophy– Cardiotrophin-1 When Carrying Different Variants of Its Gene in Men With Essential Hypertension

Cited by 4 publications

References 8 publications

Left ventricular remodeling in normotensive Wistar rats exposed to intermittent hypoxia of different duration

Left ventricular remodeling in normotensive Wistar rats exposed to intermittent hypoxia of different duration

Plasma Biomarkers for Hypertension-Mediated Organ Damage Detection: A Narrative Review

Plasma levels of galectin-3 in residents of the Podillya region of Ukraine without signs of cardiovascular pathology carriers of different variants of the coding gene (LGALS-3, rs 2274273)

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