Prognostic Significance of Bone or Cartilage Invasion of Locally Advanced Head and Neck Cancers

Do, Ly; Syed, Nisar; Puthawala, Ajmel; Azawi, Samar; Williams, R.; Vora, Nayana

doi:10.1097/coc.0b013e3181bead63

Cited by 6 publications

(4 citation statements)

References 33 publications

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“…It was therefore recommended to treat advanced carcinomas primarily by surgery with or without adjuvant radiotherapy . Although newer reports studying the outcome of definitive radiotherapy of advanced NV‐SCC are missing, there are counterparts analyzing results of head and neck‐SCC attributing similar results to definitive chemoradiation and surgery with postoperative chemoradiation of tumors with extensive soft tissue, cartilage, or bone involvement . Our data support these findings with 3 of 4 patients whose T4 tumors could be controlled successfully by definitive radiation therapy.…”

Section: Discussionsupporting

confidence: 77%

Outcome in squamous cell carcinoma of the nasal vestibule: A single center experience

et al. 2014

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Section: Discussionsupporting

confidence: 77%

Outcome in squamous cell carcinoma of the nasal vestibule: A single center experience

et al. 2014

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“…Post-surgical combined radiotherapy and chemotherapy are also helpful and are reported to increase the overall survival rate [78]. For example, Ly et al showed that similar outcomes would be achieved, between patients with bone or cartilage invasion treated with primary chemoradiotherapy (CRT) or resection followed by CRT [79]. However, the protocols of these postoperative therapies vary in different clinical centres and can only be applied in a subpopulation of OSCC patients.…”

Section: Discussionmentioning

confidence: 95%

Potential molecular targets for inhibiting bone invasion by oral squamous cell carcinoma: a review of mechanisms

Quan

Johnson

Zhou

et al. 2011

Cancer Metastasis Rev

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Bone invasion is a common characteristic of oral squamous cell carcinoma (OSCC), with adverse affects on patient functionality and survival. Recent studies suggest that it is osteoclasts, rather than malignant keratinocytes themselves, which play the major role in facilitating the entry of the tumour into bone, and its progression within bone. Osteoclasts respond to a variety of local signalling pathways, initiated by products of the malignant epithelial cells. In the present review, we firstly introduce the clinical patterns of bone invasion, and then summarise these signalling pathways and their diverse roles in sequential phases of bone invasion. We also review current researches regarding the incidence and mechanisms of distant metastases to bone, and explain briefly the concept of epithelial-mesenchymal transition, which may generate cancer stem cells and initiate the bone invasion. Finally, we discuss more briefly approaches to the diagnosis and management of OSCC patients with bone invasion. With all these studies and some recent discoveries in our own laboratory, an enhanced understanding of bone invasion will be achieved, which should indicate potential molecular targets for future biotherapies.

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“…Subset analysis of the CRT group found no differences in LC (50% and 56% at 5 years, respectively) or OS in 26 patients with bone and/or cartilage invasion compared to 42 patients with other T4 criteria. The same group later demonstrated no difference between bone or cartilage invasion [11]. Samant et al [12] also reported no difference in outcomes based on bone versus cartilage invasion in 45 patients treated with intra-arterial cisplatin and concurrent RT (CRT).…”

Section: Discussionmentioning

confidence: 99%

Prognostic significance of thyroid or cricoid cartilage invasion in laryngeal or hypopharyngeal cancer treated with organ preserving strategies

et al. 2012

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BackgroundThe utility of definitive radiotherapy (RT) for locoregionally advanced squamous cell carcinoma (SCC) of the larynx or hypopharynx in the setting of thyroid or cricoid cartilage invasion (TCCI) is controversial. A retrospective review of our experience was performed.MethodsOur institutional database of patients with SCC of the head and neck treated with radiotherapy (90% received concurrent systemic therapy) between 1995 and 2009 was queried. We identified 87 patients with T3-4 laryngeal or T4 hypopharyngeal cancer for whom initial head and neck imaging was available for review. Imaging of all patients was reviewed by a single radiologist specializing in neuroradiology. The presence and extent of TCCI was determined and used for stratification.ResultsMedian follow-up was 34 months. TCCI was found in 25 (29%) patients, eight limited to the inner cortex and another 17 involving both cortices. Local control (LC) was not significantly affected by TCCI limited to the inner cortex. However, TCCI involving both cortices was correlated with diminished LC at 2 years compared to the group of patients with no or minor invasion (55% vs. 81%, p=0.045). However, TCCI involving both cortices was not associated with significantly reduced rates of survival with a functional larynx, or overall survival (OS).ConclusionsOur results suggest that the rate of LC of T3-4 laryngeal or T4 hypopharyngeal SCC treated with definitive RT is not affected by TCCI of the inner cortex. Although decreased LC was significantly associated with TCCI involving both cortices, this factor did not appear to result in reduced rates of survival with a functional larynx or OS. Therefore, organ preservation may remain an option in these patients.

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Prognostic Significance of Bone or Cartilage Invasion of Locally Advanced Head and Neck Cancers

Abstract: This study suggests similar outcomes between patients with bone or cartilage invasion treated with upfront CRT or resection followed by CRT. Concurrent CRT may be viable alternative to resection in patients with either bone or cartilage invasion.

Cited by 6 publications

References 33 publications

Outcome in squamous cell carcinoma of the nasal vestibule: A single center experience

Outcome in squamous cell carcinoma of the nasal vestibule: A single center experience

Potential molecular targets for inhibiting bone invasion by oral squamous cell carcinoma: a review of mechanisms

Prognostic significance of thyroid or cricoid cartilage invasion in laryngeal or hypopharyngeal cancer treated with organ preserving strategies

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