Prognostic Significance of Heart Rate and its Long-term Trend in Cardiac Transplant Patients

Barge‐Caballero, Eduardo; Jiménez‐López, Jesús; Chávez-Leal, Sergio; Barge‐Caballero, Gonzalo; Paniagua‐Martin, María J.; Rivas, Raquel Marzoa; Grille-Cancela, Zulaika; Cuenca-Castillo, José J.; Castro‐Beiras, Alfonso; Crespo‐Leiro, María G.

doi:10.1016/j.rec.2014.09.028

Cited by 4 publications

(6 citation statements)

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“…A small donor–recipient weight ratio carries an increased risk of postoperative graft dysfunction and death after HT . Undersized hearts are also predisposed to chronic sinus tachycardia, a phenomenon associated with increased risk of late graft dysfunction and reduced survival . Finally, high pre‐transplant transpulmonary pressure gradient is also a consolidated risk factor for graft dysfunction and mortality after HT, both during the early postoperative period and late follow‐up…”

Section: Discussionmentioning

confidence: 99%

“…11 Undersized hearts are also predisposed to chronic sinus tachycardia, a phenomenon associated with increased risk of late graft dysfunction and reduced survival. 12 Finally, high pre-transplant transpulmonary pressure gradient is also a consolidated risk factor for graft dysfunction and mortality after HT, both during the early postoperative period 13 and late follow-up. 14 Heart transplant recipients admitted due to new-onset GF showed significant heterogeneity in their clinical presentation.…”

Section: Discussionmentioning

confidence: 99%

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Late graft failure in heart transplant recipients: incidence, risk factors and clinical outcomes

López-Sainz

Barge‐Caballero

et al. 2017

European J of Heart Fail

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Late graft failure in heart transplant recipients: incidence, risk factors and clinical outcomes

López-Sainz

Barge‐Caballero

et al. 2017

European J of Heart Fail

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“…High heart rate is an independent predictor of mortality both in the general population [ 29 ] and HTx recipients [ 2 – 4 ]. Whether or not β-blockade confers benefit in patients with cardiovascular disease remains controversial [ 30 – 32 ].…”

Section: Discussionmentioning

confidence: 99%

“…Heart transplantation (HTx) is the treatment of choice for a highly selected group of terminally ill heart failure patients with severe symptoms not responding to optimal medical combined with device-based therapy [ 1 ]. Denervation of the graft explains why HTx recipients commonly have a high heart rate, which is an independent predictor of mortality [ 2 – 4 ]. The current study builds on previous observations in a single-center cohort of HTx patients [ 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

Urinary proteomic signatures associated with β-blockade and heart rate in heart transplant recipients

et al. 2018

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ObjectivesHeart transplant (HTx) recipients have a high heart rate (HR), because of graft denervation and are frequently started on β-blockade (BB). We assessed whether BB and HR post HTx are associated with a specific urinary proteomic signature.MethodsIn 336 HTx patients (mean age, 56.8 years; 22.3% women), we analyzed cross-sectional data obtained 7.3 years (median) after HTx. We recorded medication use, measured HR during right heart catheterization, and applied capillary electrophoresis coupled with mass spectrometry to determine the multidimensional urinary classifiers HF1 and HF2 (known to be associated with left ventricular dysfunction), ACSP75 (acute coronary syndrome) and CKD273 (renal dysfunction) and 48 sequenced urinary peptides revealing the parental proteins.ResultsIn adjusted analyses, HF1, HF2 and CKD273 (p ≤ 0.024) were higher in BB users than non-users with a similar trend for ACSP75 (p = 0.06). Patients started on BB within 1 year after HTx and non-users had similar HF1 and HF2 levels (p ≥ 0.098), whereas starting BB later was associated with higher HF1 and HF2 compared with non-users (p ≤ 0.014). There were no differences in the urinary biomarkers (p ≥ 0.27) according to HR. BB use was associated with higher urinary levels of collagen II and III fragments and non-use with higher levels of collagen I fragments.ConclusionsBB use, but not HR, is associated with a urinary proteomic signature that is usually associated with worse outcome, because unhealthier conditions probably lead to initiation of BB. Starting BB early after HTx surgery might be beneficial.

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“…В последние годы были опубликованы результаты исследований, свидетельствующие о связи тахикардии с риском смерти у реципиентов трансплантированного серд-ца [73]. В одном из исследований было показано, что ЧСС > 90 мин -1 через 3 месяца после ОТТС является предиктором 10-летней летальности [74].…”

Section: бета-адреноблокаторыunclassified

Hypertension in cardiac transplant recipients

Шевченко

Никитина

Тюняева

2017

RJTAO

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1 ФГБУ «Федеральный научный центр трансплантологии и искусственных органов имени академика В.И. Шумакова» Минздрава России, Москва, Российская Федерация 2 ФГАОУ ВО «Первый Московский государственный медицинский университет имени И.М. Сеченова» Минздрава России (Сеченовский университет), Москва, Российская ФедерацияАртериальная гипертония -один из наиболее распространенных патологических синдромов среди реци-пиентов трансплантированноого сердца, как взрослых, так и детей. Хроническое повышение артериаль-ного давления является важным модифицируемым фактором риска дисфункции сердечного трансплан-тата, васкулопатии, жизнеопасных нарушений ритма, мозгового инсульта, почечной недостаточности и смерти. Данная статья построена на обзоре литературы и посвящена особенностям патогенеза, профи-лактики, немедикаментозной и лекарственной терапии посттрансплантационной артериальной гиперто-нии у реципиентов сердца.Ключевые слова: трансплантация сердца, реципиент сердца, артериальная гипертония, профилактика, лечение.

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Prognostic Significance of Heart Rate and its Long-term Trend in Cardiac Transplant Patients

Cited by 4 publications

References 35 publications

Late graft failure in heart transplant recipients: incidence, risk factors and clinical outcomes

Late graft failure in heart transplant recipients: incidence, risk factors and clinical outcomes

Urinary proteomic signatures associated with β-blockade and heart rate in heart transplant recipients

Hypertension in cardiac transplant recipients

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