Prognostic significance of KIF23 expression in gastric cancer

Liang, W M; Liu, Xiaofang; Huang, Hongyun; Gao, Zhiqiang; Li, Kai

doi:10.4251/wjgo.v12.i10.1104

Cited by 25 publications

(20 citation statements)

References 27 publications

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“…In this study, the expression level of KIF23 was high in GC tissues compared to that in adjacent normal tissues by several public databases. Recent studies suggested that KIF23 was highly expressed in GC (14,17), and related to its poor prognosis (17). Herein, we found that the pro le of KIF23 expression in GC tissue was consistent across different databases.…”

Section: Discussionsupporting

confidence: 58%

“…In lung adenocarcinoma, LINC00337 may up-regulate the expression of PBK and KIF23 through competitively binding to has-mir-373 and has-mir-519d (16). Although previous studies have con rmed the high expression of KIF23 in GC (17), the biology function and immune-related mechanism of KIF23 in mechanism remain unclear. Here, we comprehensively explored the expression and diagnostic value of KIF23, and its interactions with tumor-in ltrating immune cells (TIICs) using bioinformatics analysis.…”

Section: Introductionmentioning

confidence: 94%

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Diagnostic Biomarker KIF23 is Associated With Immune Infiltration in Gastric Cancer

Bai¹,

Liu

2021

Preprint

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Background: Kinesin family member 23 (KIF23), an index of tumor proliferation, can serve as a prognostic marker in numerous tumors. However, the relationship between KIF23 expression and immune infiltration and the diagnostic value of KIF23 remain unclear in GC (gastric cancer). This study aimed to explored the diagnostic value of KIF23 and its interactions with tumor-infiltrating immune cells in GC by bioinformatics analysis. Mothods: The relationship between clinicopathologic features and KIF23 expression was also analyzed using the Wilcoxon rank-sum test and logistic regression. And the expression level of KIF23 was validated by IHC and GEO databases, which was consistent with informatics results. Receiver operating characteristic (ROC) curves were generated to evaluate the value of KIF23 as a binary classifier using the area under the curve (AUC value).Results: High expression of KIF23 was significantly associated with longer overall survival and progression-free survival in GC. The mutations of KIF23 in GC were analyzed using cBioPortal and the Catalogue of Somatic Mutations in Cancer database. Enrichment analysis of co-expressed genes and KIF23 analysis was performed using LinkedOmics. By using STRING and GeneMANIA databases, we investigated the protein-coding genes related to KIF23 and its co-expression genes in GC tissues. Then, the relationship between KIF23 expression and immune infiltration in GC was investigated using Timer and GEPIA. We found that KIF23 might be used as a potential diagnostic biomarker in GC. Subsequently, KIF23 expression level was correlated with the infiltration levels of CD8 + T cells, macrophages, neutrophils, and more obviously with B cells and dendritic cells. In addition, KIF23 expression was significantly associated with T cell exhaustion (CTLA-4 and GZMB). KIF23 expression showed correlations with the infiltration of diverse immune markers in GC. Conclusions: Our findings suggest KIF23 can serve as a marker for immune infiltration and diagnostic in GC, making it a potential treatment of target.

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Section: Discussionsupporting

confidence: 58%

Section: Introductionmentioning

confidence: 94%

Diagnostic Biomarker KIF23 is Associated With Immune Infiltration in Gastric Cancer

Bai¹,

Liu

2021

Preprint

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“… 31 KIF23 promoted gastric carcinogenesis by activating Wnt/β-Catenin signaling. 32 , 33 Knockdown of KIF23 inhibited breast cancer cell proliferation and induced apoptosis. 34 Previous studies showed that DNA mutations in KIF23 can be found in half of cancer types with upregulated KIF23 expression and that CNAs of KIF23 are increased in 30% of tumors tested.…”

Section: Discussionmentioning

confidence: 99%

Systematic Pan-Cancer Analysis of KIF23 and a Prediction Model Based on KIF23 in Clear Cell Renal Cell Carcinoma (ccRCC)

Bai¹,

Cao²,

Yan³

et al. 2021

PGPM

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Purpose This study aims to carry out a pan-cancer analysis of kinesin family member 23 (KIF23) and construct a predictive model for the prognosis of clear cell renal cell carcinoma (ccRCC) patients. Methods We evaluated the differential expression of KIF23 in pan-cancer by The Cancer Genome Atlas (TCGA) and Oncomine database. Then, the correlation between KIF23 with prognosis, clinical grade, stage, immune subtype, tumor mutation burden (TMB), microsatellite instability (MSI) and immune microenvironment was explored by TCGA, an integrated repository portal for tumor-immune system interactions (TISIDB) and cBioPortal. Subsequently, we screened out ferroptosis-related genes (FRGs) related to KIF23 and constructed a risk score model. Univariate Cox analysis was used to determine independent prognostic factors for ccRCC overall survival (OS), and a nomogram was established. Furthermore, gene set enrichment analysis (GSEA) was applied to study the biological functions and pathways of KIF23. Finally, quantitative real-time polymerase chain reaction (qRT-PCR) was carried out to evaluate the expression of KIF23. Results KIF23 was highly expressed in most tumors. Further, KIF23 was strongly correlated with prognosis, clinical grade, stage, immune subtype, TMB, MSI and immune microenvironment in different tumors. We found that KIF23 was significantly associated with all aspects of ccRCC. Then, 8 FRGs were identified to construct a risk score model together with KIF23. And a prognostic nomogram prediction model of OS was established. After GSEA analysis, cell cycle, condensed chromosome and other physiological processes were screened out. Finally, qRT-PCR verified the high expression of KIF23 in ccRCC cell lines than normal kidney cell line. Conclusion KIF23 may act as a pivotal part in occurrence and progression of different tumors. In ccRCC, KIF23 can be a great prognostic biomarker, and the nomogram based on KIF23 may contribute to better treatment plans for ccRCC patients.

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“…It seems that elevated of KIF23 expression is a common event in various human cancers. KIF23 was reported to be overexpressed in pancreatic ductal adenocarcinoma ( Gao et al, 2020 ), malignant pleural mesothelioma ( Kato et al, 2016a ), lung cancer ( Kato et al, 2016b ; Ye et al, 2017 ), breast cancer ( Zou et al, 2014 ), hepatocellular carcinoma (HCC) ( Sun et al, 2015 ; Cheng et al, 2020 ), gastric cancer ( Li X. L. et al, 2019 ; Liang et al, 2020 ), and ovarian cancer ( Li T. et al, 2019 ; Hu et al, 2020 ). Interestingly, most studies also showed that patients with higher KIF23 expression had worse prognosis survival compared to these with lower KIF23 expression ( Kato et al, 2016b ; Ye et al, 2017 ; Li T. et al, 2019 ; Li X. L. et al, 2019 ).…”

Section: Discussionmentioning

confidence: 99%

Mutation and Copy Number Alterations Analysis of KIF23 in Glioma

et al. 2021

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In glioma, kinesin family member 23 (KIF23) is up-regulated and plays a vital role in oncogenesis. However, the mechanism underlying KIF23 overexpression in malignant glioma remains to be elucidated. This study aims to find potential causes of KIF23 high expression at genome level. To clarify this issue, we obtained point mutation and copy number alterations (CNAs) of KIF23 in 319 gliomas using whole-exome sequencing. Only two glioma samples with missense mutations in KIF23 coding region were identified, while 7 patients were detected with amplification of KIF23. Additional analysis showed that KIF23 amplification was significantly associated with higher expression of KIF23. Gene ontology analysis indicated that higher copy number of KIF23 was associated TNF-α signaling pathway and mitotic cell circle checkpoint, which probably caused by subsequent upregulated expression of KIF23. Moreover, pan-cancer analysis showed that gaining of copy number was significantly associated with higher expression of KIF23, consolidating our findings in glioma. Thus, it was deduced that elevated KIF23 expression in glioma tended to be caused by DNA copy number amplification, instead of mutation.

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Prognostic significance of KIF23 expression in gastric cancer

Cited by 25 publications

References 27 publications

Diagnostic Biomarker KIF23 is Associated With Immune Infiltration in Gastric Cancer

Diagnostic Biomarker KIF23 is Associated With Immune Infiltration in Gastric Cancer

Systematic Pan-Cancer Analysis of KIF23 and a Prediction Model Based on KIF23 in Clear Cell Renal Cell Carcinoma (ccRCC)

Mutation and Copy Number Alterations Analysis of KIF23 in Glioma

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