Prognostic significance of microalbuminuria in non-diabetic patients with acute myocardial infarction

Correlation between Urinary Albumin to Creatinine Ratio and In-hospital Cardiac Events among Patients with Acute Myocardial Infarction

“…Our study also found that the occurrences of MACE in microalbuminuria group were statistically similar to those of macroalbuminuria group. Previously, similar findings were reported by Lekatsas I et al 8 This study included only non-diabetic hospitalized AMI patients. On the other hand, our study enrolled both diabetic and non-diabetic hospitalized AMI patients.…”

Prevalence, predictors and prognostic significance of microalbuminuria in acute cardiac patients: a single center experience

“…In patients with acute myocardial infarction (AMI) [20][21][22] microalbuminuria has been reported to occur early, yielding prognostic information about in-hospital mortality additional to that provided by clinical or echocardiographic evaluation of left ventricular function. In non-diabetic patients with AMI [23], microalbuminuria has been shown to be a predictor not only for mortality but even for morbidity. In hypertensive patients with AMI [24], the combination between microalbuminuria and hypertension is associated with a higher risk of in-hospital mortality, independent of other possible confounders (such as heart failure).…”

Microalbuminuria is not associated with endothelial dysfunction and coronary atherosclerosis in patients with acute coronary syndromes

“…4,5 , [16][17][18] Several studies of individuals with or without diabetes mellitus and hypertension suggest that vascular damage, 19 endothelial dysfunction, 20 altered hemostasis in the coagulation system, 21 and vascular inflammation 22 may explain the pathogenetic linking between microalbuminuria and atherosclerosis.…”

“…Moreover, it has been reported that an appearance of microalbuminuria was associated with poor prognosis in subjects with hypertension, diabetes mellitus, and ACS. [1][2][3][4][16][17][18] A few studies [26][27][28][29][30][31] reported that microalbuminuria was associated with decreased FMD and GTN in asymptomatic patients with hypertension and diabetes mellitus. These studies showed that the presence of microalbuminuria in patients with diabetes mellitus and hypertension was associated with impaired vascular reactivity.…”

“…1,2 The presence of microalbuminuria is an independent and strong predictor of increased risk for cardiovascular morbidity and mortality in patients with diabetes mellitus, hypertension, acute coronary syndromes (ACS), as well as in subjects in general population. [1][2][3][4][5] The underlying pathophysiological mechanism of the association of albuminuria with cardiovascular disease remains unknown. Presumably it is possible that the endothelial dysfunction may explain togetherness of cardiovascular disease and renal vascular albumin leakage.…”