Prognostic Significance of p53/bcl‐2 Co‐expression in Patients With Laryngeal Squamous Cell Carcinoma

Jäckel, Martin C.; Sellmann, Ludger; Dorudian, Mansur A.; Youssef, S.; Füzesi, L.

doi:10.1097/00005537-200008000-00022

Cited by 25 publications

(20 citation statements)

References 25 publications

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“…In contrast, Hotz et al 35 reported that a high AI in pretreatment tissues was associated with a poor prognosis in advanced head and neck SCC, but their samples did not include maxillary sinus SCC. For other tumors of head and neck such as laryngeal SCC 61 and oropharyngeal SCC, 37 no correlation was found between AI and prognosis. These contradictory findings suggest that the prognostic significance of apoptosis in pretreatment status may vary among tumor sites and/or treatment manners even in head and neck lesions.…”

Section: Discussionmentioning

confidence: 92%

Prognostic value of p53 mutations, bax, and spontaneous apoptosis in maxillary sinus squamous cell carcinoma

Bandoh

Hayashi

Kishibe

et al. 2002

Cancer

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Section: Discussionmentioning

confidence: 92%

Prognostic value of p53 mutations, bax, and spontaneous apoptosis in maxillary sinus squamous cell carcinoma

Bandoh

Hayashi

Kishibe

et al. 2002

Cancer

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“…Additional sections providing a surface area of at least 1 cm 2 were stained immunohistochemically (BioGenex, CA, USA) for p53 and bcl-2. Cytoplasmic immunoexpression of bcl-2 and nuclear immunoexpression of p53 were quantified by a SAMBA image analysis system using Immuno A semi-quantitative method, known as histoscore, was also applied to the immunohistochemically stained sections (Staining percentage of cells × staining density [0,1,2,3,4] = Histoscore). 7 Quantitative and semi-quantitative values of p53 and bcl-2 protein expression for each tumour were analysed statistically to identify any correlation with tumour localization, pathological stage of the disease, tumour grade or post-operative survival rate.…”

Section: Methodsmentioning

confidence: 99%

Significance of p53 and bcl-2 Immunoexpression in the Prognosis of Laryngeal Squamous Cell Carcinoma

et al. 2002

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This study was undertaken to determine whether p53 or bcl-2 immunoexpression has any significance in the prognosis of laryngeal squamous cell carcinoma. Eighty-four cases of laryngeal squamous cell carcinoma at different pathological stages and locations were studied. All patients were treated surgically first, and followed up for 6 -96 months (mean, 35 months). p53 and bcl-2 immunoexpression in tumour cells, evaluated by image analysis and histoscore, were found in 71.4% and 46.4% of tumours, respectively. Glottic location was correlated with significantly longer survival than tumours at other locations. Pathological stage and histological grade of tumour were also significant predictors of survival. Neither p53 nor bcl-2 immunoexpression was found to be predictive of post-operative survival. Only transglottic tumours expressed significantly high levels of bcl-2. Both methods used to evaluate p53 and bcl-2 immunoexpression correlated well with each other. This study suggests that immunoexpression of p53 and bcl-2 is not a significant prognostic predictor in laryngeal squamous cell carcinoma.

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“…Growth arrest in wild-type P53 is dependent on transcriptional activation of P21, which ultimately inhibits cyclin complexes and arrests cells in the G1 to S phase transition (Clarke et al, 1993;Chang et al, 1997;Bouvard et al, 2000). Through the activation of BAX, a proapoptotic gene, and downregulation of BCL-2, an anti-apoptotic gene, P53 plays an essential role in apoptosis (Lane, 1992;Clarke et al, 1993;elDeiry et al, 1994;Silvestrini et al, 1994;Gallo et al, 1999;Sionov and Haupt, 1999;Dijkema et al, 2000;Jackel et al, 2000). It follows that cellular response to radiation may be dependent on a normally functioning P53 gene.…”

Section: P53mentioning

confidence: 99%

Molecular markers in clinical radiation oncology

Haffty¹,

Glazer²

2003

Oncogene

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Radiation therapy plays a critical role in the management of a majority of patients diagnosed with cancer. Identification of factors that help predict which patients are at risk for relapse within the irradiated field remains an active area of investigation. Although conventional clinical and pathologic factors have been helpful in identifying risk and guiding clinical decision-making for both local and systemic management, there is clearly a need to identify additional prognostic markers, which can aid in refining our treatment strategies and improving outcomes. A substantial amount of research efforts have been devoted to identifying molecular markers for prognostic and therapeutic strategies. The recent emergence of a powerful armamentarium of molecular tools has resulted in rapid expansion of our fund of knowledge and understanding of the molecular biology underlying tumor behavior and response. While a majority of these efforts have been focused on risk factors for metastatic disease and survival, there is a rapidly growing body of literature focused on molecular factors associated with radiation resistance and locoregional failure. In this review, we summarize recent advances and the available literature evaluating molecular markers as they relate to radiation sensitivity of solid tumors. Literature regarding the potential application of expression of genes related to apoptosis, angiogenesis, cell cycle, DNA repair and growth factors will be reviewed. Some of the basic biology and laboratory evidence demonstrating how the marker relates to radiation response and available correlative clinical studies employing these markers as prognostic tools are presented. The majority of molecular markers that have potential clinical significance with respect to radiation sensitivity and local control will be highlighted.

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Prognostic Significance of p53/bcl‐2 Co‐expression in Patients With Laryngeal Squamous Cell Carcinoma

Cited by 25 publications

References 25 publications

Prognostic value of p53 mutations, bax, and spontaneous apoptosis in maxillary sinus squamous cell carcinoma

Prognostic value of p53 mutations, bax, and spontaneous apoptosis in maxillary sinus squamous cell carcinoma

Significance of p53 and bcl-2 Immunoexpression in the Prognosis of Laryngeal Squamous Cell Carcinoma

Molecular markers in clinical radiation oncology

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