Prognostic significance of peri-operative blood transfusion following radical resection for oesophageal carcinoma

Dresner, Samuel M.; Lamb, PJ; Shenfine, Jonathan; Hayes, Nick; Griffin, S. M.

doi:10.1053/ejso.1999.0929

Cited by 77 publications

(55 citation statements)

References 34 publications

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“…They also showed that natural killer cell activity remained higher in the autologous group (p < 0.05) and suggested this as a possible mechanism influencing survival [10]. Furthermore, there is evidence that the increased risk for both infection [5] and disease recurrence [61][62][63] is dose related, with the increased risk of recurrence starting at a threshold of 3-4 units of allogeneic blood transfusion, depending on tumour type.…”

Section: Discussionmentioning

confidence: 99%

Use of a leucocyte filter to remove tumour cells from intra‐operative cell salvage blood

Catling¹,

Williams²,

Freites³

et al. 2008

Anaesthesia

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SummaryThe intra-operative blood loss of 50 consecutive gynae-oncology patients undergoing surgery for endometrial, cervical or ovarian cancer was cell salvaged and filtered. In each case blood samples were taken from the effluent tumour vein, a central venous line, the cell saver reservoir, the cell salvage re-transfusion bag after processing but before filtration and from the cell salvage re-transfusion bag after processing and filtration. Samples were examined using immunohistochemical monoclonal antibody markers for epithelial cell lines. Viable, nucleated malignant cells were detected in 2 ⁄ 50 central venous samples, 34 ⁄ 50 reservoir samples and 31 ⁄ 50 unfiltered cell salvaged samples. After passage through a Pall RS leucocyte depletion filter no remaining viable, nucleated malignant cells were detected in any sample. The clinical risks of cell salvage in these circumstances should be reviewed in the light of the risks of allogeneic blood transfusion.

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Section: Discussionmentioning

confidence: 99%

Use of a leucocyte filter to remove tumour cells from intra‐operative cell salvage blood

Catling¹,

Williams²,

Freites³

et al. 2008

Anaesthesia

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“…The more frequent use of transhiatal over transthoracic esophagectomy in elderly patients may also have contributed to the low cardiopulmonary-related mortality [13] . Moreover, shorter operative time, reduced blood loss and fewer perioperative blood transfusion in recent years may all have important impact on the reduced incidence of cardiopulmonary complications during this period [14][15][16][17] . Finally, there has been considerable improvement in postoperative pain control by epidural anesthesia block.…”

Section: Discussionmentioning

confidence: 99%

Clinicopathologic characteristics of esophagectomy for esophageal carcinoma in elderly patients

Zhu²,

Wang³

et al. 2006

WJG

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operation time, blood loss, and percentage of patients receiving blood transfusion of the elderly patients significantly improved from the former period to the recent period. The hospital mortality rate of the elderly patients dropped from the former period (5.9%) to the recent period (2.3%), but it was not statistically significant. CONCLUSION:Preoperative medical risk factors and postoperative cardiopulmonary complications after esophagectomy are more common in the elderly, but operative mortality is comparable to that of younger patients. These encouraging results and improvements in postoperative mortality and morbidity of the elderly patients in recent period are attributed to better surgical techniques and more intensive perioperative care in the elderly.

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“…9 -12 Decreased survival in patients with esophageal carcinoma who have received an allogenic blood transfusion have been reported previously. [13][14][15][16] In the current study, univariate analysis demonstrated that the survival rates of patients who received an allogenic blood transfusion were significantly more unfavorable compared with those of patients who did not receive a blood transfusion. However, there was a significantly higher proportion of more advanced disease in transfused patients compared with patients who did not receive a transfusion, perhaps because intraoperative blood transfusion was required more frequently when more difficult surgical manipulation was required to dissect the advanced tumors.…”

Section: Discussionmentioning

confidence: 46%

“…9 -12 With regard to esophageal carcinoma, decreased survival in patients undergoing allogenic blood transfusion has been reported in some studies. [13][14][15][16] However, to our knowledge the significance of allogenic blood transfusion in the prognosis of patients with esophageal carcinoma, which has been accepted as having more malignant potential compared with neoplasms in other organs, remains controversial.…”

mentioning

confidence: 99%

Significance of allogenic blood transfusion on decreased survival in patients with esophageal carcinoma

Nozoe

Miyazaki

Saeki

et al. 2001

Cancer

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Prognostic significance of peri-operative blood transfusion following radical resection for oesophageal carcinoma

Cited by 77 publications

References 34 publications

Use of a leucocyte filter to remove tumour cells from intra‐operative cell salvage blood

Use of a leucocyte filter to remove tumour cells from intra‐operative cell salvage blood

Clinicopathologic characteristics of esophagectomy for esophageal carcinoma in elderly patients

Significance of allogenic blood transfusion on decreased survival in patients with esophageal carcinoma

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