Significance of allogenic blood transfusion on decreased survival in patients with esophageal carcinoma

Correlations Between Neoadjuvant Treatment, Anemia, and Perioperative Complications in Patients Undergoing Esophagectomy for Cancer

“…In an earlier report from our institution which included 143 patients treated with Ivor-Lewis esophagectomy, we reported that perioperative transfusion was a significant predictor of decreased overall survival but was not associated with an increased complication rate or surgical death [27]. On the other hand, other reports have shown an increase in short-term complications following administration of blood products in surgical patients [22,24,25,28,29], and specifically after esophagectomy [30,31]. Kinugasa et al found that the administration of blood transfusion was associated with a higher risk of pulmonary complications after esophagectomy; however, they excluded patients that received neoadjuvant treatment [31].…”

Clinicopathologic characteristics of esophagectomy for esophageal carcinoma in elderly patients

“…The more frequent use of transhiatal over transthoracic esophagectomy in elderly patients may also have contributed to the low cardiopulmonary-related mortality [13] . Moreover, shorter operative time, reduced blood loss and fewer perioperative blood transfusion in recent years may all have important impact on the reduced incidence of cardiopulmonary complications during this period [14][15][16][17] . Finally, there has been considerable improvement in postoperative pain control by epidural anesthesia block.…”

Leukocyte Depletion in Allogeneic Blood Transfusion Does Not Change the Negative Influence on Survival Following Transthoracic Resection for Esophageal Cancer

“…The authors suggest that complications that necessitate transfusions were responsible for this observation because no increase in local or distant tumor recurrences were identified. Nozoe et al 3 also found that the occurrence of postoperative complications was a prognostic factor, whereas perioperative allogeneic blood transfusions were not in patients with squamous cell cancer.…”

“…Some authors assumed decreased survival with perioperative blood transfusion to be rather a reflection of circumstances necessitating transfusion. 2,3 Others demonstrated a significantly independent relationship by multivariate analysis. [4][5][6] Studies exploring underlying mechanisms showed a decreasing number of circulating T lymphocytes with a decreased ratio of helper-to-suppressor T lymphocytes.…”

“…10 Previous studies dealing with blood transfusion in esophageal surgery did not deal with leukocyte-depleted transfusions. [2][3][4][5][6]11 After the mandatory introduction in Germany in 2001, pre-storage leukocyte-depleted products are used without exception, with an amount of contaminating leukocytes of less than 1×10 6 /unit according to the European consensus. 12 In this retrospective analysis, we evaluated the prognostic influence of perioperative allogeneic blood transfusions in patients with esophagectomy for esophageal cancer.…”