2014
DOI: 10.1159/000365477
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Prognostic Significance of Pretreatment Plasma Fibrinogen and Platelet Levels in Patients with Early-Stage Cervical Cancer

Abstract: Background: Hyperfibrinogenaemia and thrombocytosis, which usually occur in cancer patients, have been shown to contribute to cancer cell growth, progression, and metastasis. The aims of the present study were to assess the prognostic significance of pretreatment plasma fibrinogen and platelet levels in early-stage cervical cancer patients. Methods: The present study was a retrospective analysis of 220 cervical cancer patients with stage I-IIA disease. The pretreatment plasma fibrinogen and platelet levels wer… Show more

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Cited by 41 publications
(41 citation statements)
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“…Our study also demonstrated that platelet, leukocyte, and albumin were correlated with OS independently in cancer patients, which was consistent with previous reports. 17,18,26 Notably, BMI indicates a better survival prognosis than low BMI for cervical cancer patients in our retrospective study. A large study composed of 738 cervical cancer patients also demonstrated that high BMI influenced OS favorably.…”
Section: Discussionmentioning
confidence: 64%
See 1 more Smart Citation
“…Our study also demonstrated that platelet, leukocyte, and albumin were correlated with OS independently in cancer patients, which was consistent with previous reports. 17,18,26 Notably, BMI indicates a better survival prognosis than low BMI for cervical cancer patients in our retrospective study. A large study composed of 738 cervical cancer patients also demonstrated that high BMI influenced OS favorably.…”
Section: Discussionmentioning
confidence: 64%
“…12 Nomograms have been accepted as reliable tools to stratify risk by incorporating valuable factors for oncological outcomes, 13,14 including cervical cancer. 15,16 Currently, some variables were confirmed to have additional prognostic value in predicting patients' prognosis, such as hematological data, 17,18 body mass index (BMI), 19 age, sex, 20 and so on.…”
mentioning
confidence: 99%
“…These include regional lymph node metastasis, parametrium involvement, positive surgical margin, lymphovascular space involvement, deep stromal invasion, and large tumor size [3,4,5]. However, these pathological factors cannot be used to define the prognosis prior to treatment or for patients who have not received surgery.…”
Section: Introductionmentioning
confidence: 99%
“…The association between thrombocytosis and OS was reported in 13 studies enrolling 3,341 patients [719]. Six of the eligible studies reported a non-statistically significant hazard ratio, a forest plot of all studies was shown in Figure 2.…”
Section: Resultsmentioning
confidence: 98%
“…And there was absence of evidence for inter-study heterogeneity ( I 2 = 24.5%, P = 0.196). Four studies comprising 499 patients covered hazard ratios for RFS [7, 12, 13, 15], the meta-analysis found that pretreatment thrombocytosis was associated with poor RFS in cervical cancer (HR: 1.67, 95% CI: 1.15–2.42; P = 0.007) (Figure 3). And there was absence of evidence for inter-study heterogeneity ( I 2 = 38.2%, P = 0.183).…”
Section: Resultsmentioning
confidence: 99%