Prognostic significance of proinflammatory factors in patients with progressive angina pectoris and type 2 diabetes mellitus

Abstract

Aims. Our study was aimed to assess the influence of non-specific inflammation and endothelial dysfunction on developmentof cardiovascular events in patients with type 2 diabetes mellitus (T2DM) and progressive angina pectoris. Materials and methods. 140 patients (63 of them were also diabetic) received follow-up for cardiovascular events during12 months after an episode of unstable angina pectoris. Upon hospitalization for acute coronary syndrome analyses wereperformed to assess the degree of systemic inflammation evaluating plasma concentration of pro- and anti-inflammatorymarkers (CRP, fibrinogen, IL-6, -8, -10, TNF-?), as well as blood glucose and glycated haemoglobin HbA1c. Results. TNF-? and IL-6 levels were significantly higher in patients with unfavorable prognosis (p

Clinical And Laboratory Features Of Cardiorenal Syndrome On The Background Of Carbohydrate Exchange Disorders

“…During the investigation of indicators of oxidative stress in patients with myocardial infarction (MI), it was revealed that patients with complicated postinfarction period are characterized by a significant increase in the activity of lipid peroxidation (LPO) and a decrease in antioxidant protection [2] .The predictive role of systemic inflammation in hyperglycemic conditions is confirmed by a number of studies. So it was found that patients after an episode of unstable angina pectoris in combination with diabetes had higher values of indicators of inflammation markers, which were associated with a complicated course of the hospital period, in contrast to patients without carbohydrate metabolism disorders (CMD) [1]. Moreover, role of complex immune reactions in the processes of atherogenesis is beyond doubt.…”

Clinical and Pathogenetic Aspects of Cardiorenal Relationships on Background of Type 2 Diabetes

“…Прогностическая роль системного воспаления в условиях гипергликемии подтверждается рядом проведенных исследований. Так установлено, что пациенты после перенесенного эпизода нестабильной стенокардии в сочетании с СД имели более высокие значения показателей маркеров воспаления, которые ассоциировались с осложненным течением госпитального периода, в отличии от больных без нарушения углеводного обмена (НУО) [1]. Кроме того, роль комплексных иммунных реакций в процессах атерогенеза не вызывает сомнений.…”

Clinical significance of the cardio-ankle vascular index in patients with stroke

“…. Была показана связь СЛСИ с субклиническими поражениями сердца [7], распространенностью коронарного [8] и некоронарного [9] атеросклероза. До настоящего времени лишь единичные работы посвящались изучению роли данного индекса у неврологических больных [10][11][12].…”