Prognostic significance of serum Her2/neu, BCL2, CA15-3 and CEA in breast cancer patients: A short follow-up

Samy, Nervana; Ragab, Halla M.; Maksoud, Nabila Abd El; Shaalan, Mohamed

doi:10.3233/cbm-2009-0119

Cited by 48 publications

(41 citation statements)

References 34 publications

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“…This finding is in acordance with the results of Samy et al . [46], who found that preoperative serum levels of CA15-3 and CEA were significantly higher in breast cancer patients compared with the levels of the control group, and these markers decreased after operation.…”

Section: Discussionmentioning

confidence: 99%

Leptin receptor Q223R polymorphism in Egyptian female patients with breast cancer

El-Hussiny¹,

Atwa²,

Rashad³

et al. 2017

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Aim of the studyBreast cancer is the most common cause of death in women. Obesity has been associated with increased risk of breast cancer in post-menopausal women. It induces chronic inflammation, which increases local and systemic levels of cytokines and adipokines such as leptin. Leptin (LEP) and leptin receptor (LEPR) genes have several polymorphisms in humans. This study aims to assess the association between blood levels of leptin and LEPR Q223R gene polymorphism in patients of cancer breast.Material and methodsThe current study was carried on 48 female breast cancer patients and 48 heathy female subjects. Carcinoembryonic antigen (CEA), cancer antibody CA15-3, and leptin hormone were determined. Single nucleotide polymorphism of LEPR Q223R was assessed by PCR/RFLP. Statistical analysis used: The statistical analysis of data was done by using SPSS version 20.ResultsThere were significant increases in the concentrations of CEA (p = 0.004), CA15-3 (p < 0.001), and leptin hormone (p < 0.001) in BC patients in relation to the respective concentrations in control subjects. CEA and CA 15-3 showed significant differences between various BC stages. As regard to LEPR Q223R gene polymorphism, AA genotype showed significantly higher frequency in BC patients when compared to their respective controls, with higher risk to develop BC.ConclusionsLeptin hormone shows significantly higher concentrations in BC patients. As regard to LEPR Q223R gene polymorphism, AA genotype showed significantly higher frequency in BC patients.

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Section: Discussionmentioning

confidence: 99%

Leptin receptor Q223R polymorphism in Egyptian female patients with breast cancer

El-Hussiny¹,

Atwa²,

Rashad³

et al. 2017

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“…Since then, several other studies have also elaborated on the independent negative impact of these serum markers on the prognosis of the patients with breast cancer. Elevated serum levels of HER2 were associated with several factors related to tumor aggressiveness of breast cancer, such as tumor size, advanced stage, lymph node involvement, poor histological differentiation and shorter disease free and/or overall survival (Azizun-Nisa et al, 2008;Samy et al, 2010;Kong et al, 2012;Ma et al 2012;Wang et al, 2012). Sharif et al (2010) showed a positive association of Her-2 immunohistochemical expression with tumour size and lymph node metastasis only in post-menopausal women, indicating an age-related association of Her-2 expression with the histological prognostic markers in breast carcer.…”

Section: Discussionmentioning

confidence: 99%

Overall Survival and Clinicopathological Characteristics of Patients with Breast Cancer in Relation to the Expression Pattern of HER-2, IL-6, TNF-α and TGF-β1

Tripsianis

Papadopoulou²,

Romanidis³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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The present study was conducted to investigate the prognostic significance of co-expression patterna of HER-2, IL-6, TNF-a and TGF-β1 in breast cancer, by correlating the number of markers with positive expression with clinicopathological characteristics indicative of tumor progression and overall survival. One hundred thirty consecutive patients with primary breast cancer were prospectively included and evaluated. Serum concentrations of the above markers were measured by ELISA. Median split was used to subdivide patients with marker positive or negative expression. The presence of ≥3 positive markers was independently associated with extended lymph node (>3) involvement (aOR, 11.94, p=0.001) and lymphovascular invasion (aOR, 12.04, p=0.018), increasing the prognostic significance of each marker considered separately. Additional prognostic information regarding survival was also provided; as the number of positive markers increased, a gradually reduction of survival time was observed. In addition, patients with 4 positive markers had significantly shorter survival (25 vs 39 months, p=0.006) and a more than 4 fold increased risk of death (aHR, 4.35, p=0.003) compared to patients with 3 positive markers. Our findings suggest that the coexpression pattern of these four markers could be used clinically as a useful marker for tumor extension and outcome of breast cancer.

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“…[2324] Although advances in immunohistochemistry are very promising, there is still much work that needs to be done to characterize metastases. [252627] A recent letter to the editor highlights the pitfalls that can occur when differentiating primary cutaneous apocrine carcinoma from a metastasis. [28] Although cytokeratin 5/6 is associated with cutaneous apocrine carcinoma, this staining pattern has also been noted with metastatic squamous cell carcinoma [Figure 3c].…”

Section: Diagnosis and Immunohistochemistrymentioning

confidence: 99%

The presentation, pathology, and current management strategies of cutaneous metastasis

et al. 2013

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Skin metastases are rare in the routine clinical practice of dermatology, but are of major clinical significance because they usually indicate advanced disease. We reviewed the literature on skin metastasis regarding recent trends in clinical presentation and diagnosis of the most common cutaneous lesions. An extensive literature review was conducted using PubMed from May 26, 2011 to July 16, 2013 relating cutaneous metastases. Articles chosen for reference were queried with the following prompts: “Cutaneous metastases”, “clinical presentation”, “histological features”, and “immunohistochemistry”. Further searches included “treatment” and “management” options for “metastatic breast”, “metastatic colorectal”, “metastatic melanoma”, “metastatic lung”, and “hematologic cancers.” We also reviewed the literature on the current management of melanoma as a model for all cutaneous metastatic disease. Our own clinical findings are presented and compared to the literature. Additionally, we highlight the most useful immunohistochemical studies that aid in diagnoses. Several novel therapies and combination therapies such as electrochemotherapy, vemurafenib, and imiquimod will be discussed for palliative treatment of cancers that have been found to improve cutaneous lesions. We review these notable findings and developments regarding skin metastases for the general dermatologist.

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Prognostic significance of serum Her2/neu, BCL2, CA15-3 and CEA in breast cancer patients: A short follow-up

Cited by 48 publications

References 34 publications

Leptin receptor Q223R polymorphism in Egyptian female patients with breast cancer

Leptin receptor Q223R polymorphism in Egyptian female patients with breast cancer

Overall Survival and Clinicopathological Characteristics of Patients with Breast Cancer in Relation to the Expression Pattern of HER-2, IL-6, TNF-α and TGF-β1

The presentation, pathology, and current management strategies of cutaneous metastasis

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