Prognostic significance of sex in patients with primary tracheal tumors – a retrospective, single-center study

Piórek, Aleksandra; Płużański, Adam; Kowalski, Dariusz M.; Krzakowski, Maciej

doi:10.5603/njo.a2021.0069

Cited by 3 publications

(4 citation statements)

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“…Positive prognostic factors include a histological diagnosis of ACC [3, 6, 14-16, 19-21, 33, 59-63], good overall patient condition [15,20,[64][65][66], and radical surgical treatment [6,7,10,14,20,40,59,62,67]. Authors have also highlighted the significance of tumor stage and sex [22,68].…”

Section: Discussionmentioning

confidence: 99%

Tracheal cancers

Piórek,

Płużański,

Winiarczyk

et al. 2024

Oncol Clin Pract

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Primary tracheal tumors are very rare and the literature on this subject is limited. Due to their rarity and diversity, the provision of patient care in terms of optimal management poses a considerable challenge. There are no unequivocal guidelines concerning the treatment in patients with local or distant disease. The most common types of primary tracheal tumors are squamous cell carcinoma and adenoid cystic carcinoma. Squamous cell carcinoma of the trachea is 2-4 times more common in men than in women and develops primarily in the sixth and seventh decades of life. It is strongly associated with tobacco smoking. Adenoid cystic carcinoma of the trachea occurs with similar frequency in men and women, and is most common in the fourth and fifth decades of life. The etiology of this type is unknown, however it is not associated with tobacco smoking. Adenoid cystic carcinoma is characterized by submucosal and perineural spread. Treatment of patients with primary tracheal tumors requires a multidisciplinary approach. Optimal treatment of localized tumors is based on surgery or radiotherapy. If distant metastases are present the therapeutic palliative methods are: chemotherapy, palliative radiotherapy or palliative surgery. The prognosis of patients with primary tracheal tumors is determined by several factors. Histological diagnosis of adenoid cystic carcinoma, good performance status, and complete resection have been identified as favorable prognostic factors. Despite intensive treatment, the 5-year survival rate for primary tracheal tumors is not satisfactory.

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Section: Discussionmentioning

confidence: 99%

Tracheal cancers

Piórek,

Płużański,

Winiarczyk

et al. 2024

Oncol Clin Pract

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“…The present study was a retrospective analysis of consecutive patients with primary tracheal tumors treated at the National Research Institute of Oncology in Warsaw, Poland, between January 2000 and December 2016. All patients were included in our previously reported analysis describing the TNM (tumor, node, metastases) staging system and the prognostic significance of sex in patients with primary tracheal tumors 20,21 . Pathology reports and hospital records were reviewed to exclude laryngeal cancer and tumors of the lung with extension to the carina.…”

Section: Methodsmentioning

confidence: 99%

“…All patients were included in our previously reported analysis describing the TNM (tumor, node, metastases) staging system and the prognostic significance of sex in patients with primary tracheal tumors. 20 , 21 Pathology reports and hospital records were reviewed to exclude laryngeal cancer and tumors of the lung with extension to the carina. In general, the records of 89 actively treated patients with primary tracheal tumor were included.…”

Section: Methodsmentioning

confidence: 99%

Clinicopathological characteristics of patients with primary tracheal tumors: Analysis of eighty‐nine cases

Piórek,

Płużański,

Teterycz

et al. 2024

Thoracic Cancer

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BackgroundPrimary tracheal tumors are very rare and the literature on this subject is limited. The most common histological type of primary tracheal tumors is squamous cell carcinoma (SCC), followed by adenoid cystic carcinoma (ACC). Limited knowledge exists regarding the behavior and outcomes of different histological types of tracheal cancers. The present study aimed to address this gap by assessing the significance of the histological type of primary tracheal tumors based on our own data and to review the literature.MethodsWe carried out a retrospective analysis of 89 patients with primary tracheal tumors treated at the Maria Sklodowska‐Curie National Research Institute of Oncology in Warsaw, Poland, between 2000 and 2016. The study assessed patient demographics, tumor characteristics and treatment, with a focus on SCC, ACC, and other histological types. Different histological types were compared in terms of overall survival, disease‐free survival, and progression‐free survival.ResultsSCC was the most frequently diagnosed histological type (56.2%), followed by ACC (21.3%). Patients with SCC were typically older (78% over 60 years), predominantly male (66%), and associated with smoking. In contrast, the ACC had a more balanced gender distribution and did not correlate with smoking. ACC displayed a significantly better prognosis, with a median overall survival of 129.4 months, compared with 9.0 months for SCC.ConclusionHistological type plays a crucial role in the prognosis of primary tracheal tumors. ACC demonstrated a more favorable outcome compared with SCC.

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“…This retrospective analysis included patients with primary tracheal tumors treated at the National Research Institute of Oncology in Warsaw, Poland, between January 2000 and December 2016. All patients were included in our previously reported analysis describing the TNM (tumor, node, metastases) staging system and the prognostic significance of sex in patients with primary tracheal tumors [ 27 , 28 ]. The patients were identified by searching the institution’s cancer registry.…”

Section: Methodsmentioning

confidence: 99%

Treatment outcomes of patients with primary tracheal tumors - analysis of a large retrospective series

Piórek,

Płużański,

Knetki-Wróblewska

et al. 2024

BMC Cancer

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Objective Primary tracheal tumors are very rare and their management is not definitely established. Due to its rarity, providing patient care in terms of optimal management poses a considerable challenge. The purpose of this study was to investigate treatment outcomes in patients with these rare tumors. Methods We carried out a retrospective analysis of 89 patients with primary tracheal tumors treated at the Maria Sklodowska-Curie National Research Institute of Oncology in Warsaw, Poland, over sixteen years. The study assessed patient demographics, tumor characteristics and treatment. Different treatment options were compared in terms of overall survival, disease-free survival, and progression-free survival. Results A total of 89 patients were included in the study. In the group presented, 45 patients underwent primary radical treatment and 44 were qualified for palliative treatment. Surgical resection was performed in 13 patients out of radically treated patients. The 5 year OS rates in the group of patients who underwent radical treatment and in the group of patients who underwent palliative treatment were 45.9% and 2.3%, respectively. In the group of patients who underwent radical surgical treatment, the 5 year OS was 76.9% compared to 35.8% in the group of patients who underwent nonsurgical treatment. Conclusion A multidisciplinary team should decide treatment options, including in-depth consideration of surgical treatment options.

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Prognostic significance of sex in patients with primary tracheal tumors – a retrospective, single-center study

Cited by 3 publications

References 40 publications

Tracheal cancers

Tracheal cancers

Clinicopathological characteristics of patients with primary tracheal tumors: Analysis of eighty‐nine cases

Treatment outcomes of patients with primary tracheal tumors - analysis of a large retrospective series

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