Adverse events may predict the outcomes of cancer patients. Apart from skin rash, change in D-dimer concentration may be valuable parameter in creation of predictive and prognostic models in NSCLC patients receiving anti-EGFR targeted therapy.

Due to the low incidence of primary tracheal neoplasms, there is no uniform system for staging of this disease. Our retrospective analysis based on registry data included 89 patients diagnosed with primary tracheal cancer at the National Research Institute of Oncology in Warsaw, Poland, between January 2000 and December 2016. We analyzed demographic, clinical, pathological, therapeutic, and survival data. The staging—for the purpose of our analysis—was performed retrospectively on the basis of imaging results. Tumor (T) category was defined as a disease confined to the trachea or lesion derived from the trachea and spreading to adjacent structures and organs. Node (N) and metastases (M) categories were divided into absence/presence of metastasis in regional lymph nodes and the absence/presence of distant metastasis. Survival analysis was performed depending on the clinical presentation of these features. There was a significant difference in overall survival depending on the T, N, M categories in the entire group. In the group of patients undergoing radical treatment, the T and N categories had a statistically significant impact on overall survival. In the group of patients treated with palliative aim, only the T category had an impact on overall survival. Multivariate analysis showed statistical significance for the T category in patients undergoing radical and those receiving palliative treatment. The assessment of the anatomical extent of lesions may help decide about treatment options and prognosis.

This paper presents the results of a study of the treatment of transverse tibial shaft fractures in six sheep with the use of interlocking nails and type I extemal fixators. During surgery, tibial osteotomy was performed to induce an experimental fracture which was stabilized using a type I extemal fixator. Osteosynthesis was monitored for nine weeks by performing clinical tests, observing the degree of lameness and subjecting the patients to weekly radiological examinations. After nine weeks, the animals were euthanized, and samples of bone callus were sampled for histopathological analyses. Weight bearing on the fractured limb began on day 2 to 4 after treatment. Limb function was fully restored around five weeks after surgery. Radiograms taken during the observation period revealed gradual hyperplasia and progressing mineralization of bone callus at different stages of healing. The histopathological picture of the bone callus was characteristic of the phase of bone turnover and remodeling.

Purpose: Adenoid cystic carcinoma (ACC) of trachea is a relatively rare malignant neoplasm, for which there is a lack of prospective clinical trials investigating treatment effectiveness. Most of the authors prefer surgical resection followed by post-operative radiation therapy in case of incomplete excision. There are no available prospective data on post-relapse treatment.Case presentation: The current paper presents a case of tracheal ACC in a young woman, treated solely with surgical resection without radiotherapy due to postoperative neurological complications requiring additional diagnostics, management, and treatment. As a complication itself, spinal cord dysfunction after tracheal surgery is extremely rare, in which radical radiotherapy and brachytherapy were successfully administered after disease recurrence.Conclusions: Lack of post-operative radiotherapy resulting from neurological complications could be a reason for ACC recurrence in our patient. Administration of radiotherapy after incomplete resection of recurrent disease may lead to long-term locoregional control.

Introduction.We aimed to assess the prognostic significance of the sex of patients with primary tracheal tumors based on our own results as well as the literature review. Material and methods. We carried out a retrospective analysis of 89 patients with primary tracheal tumors treated at the