Prognostic significance of the extent of cervical involvement by endometrial cancer

Fanning, James; Alvarez, Pedro M.; Tsukada, Yoshiaki; Piver, M. Steven

doi:10.1016/0090-8258(91)90084-i

Cited by 45 publications

(14 citation statements)

References 8 publications

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“…Several investigators have reported that gross cervical involvement appeared to impart a prognosis worse than microscopic involvement [1,2,5,6]. Therefore, patients with cervical involvement, especially with gross involvement, may be treated by radical surgery or additional radiotherapy [4][5][6].…”

Section: Discussionmentioning

confidence: 98%

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Value of Dynamic MR Imaging in Assessing Endometrial Carcinoma Involvement of the Cervix

Seki

Takano²,

Sakai³

2000

American Journal of Roentgenology

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Section: Discussionmentioning

confidence: 98%

“…ndometrial carcinoma involvement of the cervix is one of the important prognostic factors related to extrauterine tumor spread, in addition to histologic tumor grade and depth of myometrial invasion [1][2][3]. In patients with endometrial carcinoma, total abdominal hysterectomy with bilateral salpingo-oophorectomy is the traditional treatment.…”

mentioning

confidence: 99%

Value of Dynamic MR Imaging in Assessing Endometrial Carcinoma Involvement of the Cervix

Seki

Takano²,

Sakai³

2000

American Journal of Roentgenology

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“…But FIGO did not provide guidelines regarding the histologic distinction of stromal from gland involvement, and different authors have considered it to reflect surface epithelial involvement only, surface and underlying gland involvement, or mucosal spread [5][6][7][8][9]. Various studies have yielded conflicting data, with survival and recurrence rates for women with stage IIB disease either worse than or no different than those for women with stage IIA disease [5][6][7][8][9][10][11][12][13]. In some studies, stage IIA disease is associated with the same prognosis as stage I tumors.…”

Section: Introductionmentioning

confidence: 99%

Endocervical involvement in endometrial adenocarcinoma is not prognostically significant and the pathologic assessment of the pattern of involvement is not reproducible

Zaino

Abendroth

Yemelyanova³

et al. 2013

Gynecologic Oncology

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“…9 However, several studies published subsequently showed that clinical staging had an unacceptably high inaccuracy rate, failing to detect extra-uterine spread of disease in at least 15-20% of cases. [10][11][12][13][14][15][16] Additionally, one of the main reasons for clinical staging, the administration of preoperative radiotherapy, fell into disfavor among gynecologists in the mid-1980s. Thus, following the tri-annual meeting of the oncology committee of FIGO in 1988, it was recommended that all endometrial cancers be surgically staged if the patient has an acceptable risk-to-benefit ratio for surgery.…”

mentioning

confidence: 99%

Upstaging based solely on positive peritoneal washing does not affect outcome in endometrial cancer

et al. 2005

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Surgical staging of endometrial carcinoma includes the collection of peritoneal washings in the abdomen and pelvis. A positive finding upstages patients to International Federation of Gynecology and Obstetrics stage IIIA. However, the prognostic significance of such an upstaging, and thus the justification for the routine performance of this procedure, is unclear. This 5-year retrospective study was conducted to determine the frequency and prognostic significance of upstaging of endometrial carcinoma based solely on positive washings. The cohort for the study was collected by review of pathology reports of all washings that were performed prior to hysterectomies for suspected endometrial carcinomas over a 5-year period (01/1995-12/ 1999). Cases with positive cytology were selected if there was no grossly apparent intraperitoneal disease, no histologic evidence of extra-uterine tumor and the cases would otherwise have been considered stage I or II (case group). An age-matched control group was selected of stage I and II patients with the same histologic subtypes and negative washings (n ¼ 19). Of 220 endometrial carcinomas, peritoneal washing cytology was abnormal in 19 (8.6%) and was solely responsible for upstaging only 10 patients (4.5% of all cases, eightendometrioid, one-serous, one-mixed; nine stage IA or IB and one stage IIB). Adjuvant therapy was administered in 90% of the case group and 74% of the control group. After a median follow-up of 51 months (case group) and 63 months (control group), we found only a single patient with progression of disease (recurrence, metastases or death) in the control group. It is concluded that abnormal cytology without other evidence of extrauterine disease leads to upstaging of a minority of endometrial carcinoma patients (4.5%), but does not appear to affect their overall outcome. Although this is a small single site study, it raises questions about the value of this procedure in patients with endometrial cancer.

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Prognostic significance of the extent of cervical involvement by endometrial cancer

Cited by 45 publications

References 8 publications

Value of Dynamic MR Imaging in Assessing Endometrial Carcinoma Involvement of the Cervix

Value of Dynamic MR Imaging in Assessing Endometrial Carcinoma Involvement of the Cervix

Endocervical involvement in endometrial adenocarcinoma is not prognostically significant and the pathologic assessment of the pattern of involvement is not reproducible

Upstaging based solely on positive peritoneal washing does not affect outcome in endometrial cancer

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