Prognostic Significance of the Neutrophil-to-Lymphocyte Ratio in Primary Liver Cancer: A Meta-Analysis

Xue, Tong-Chun; Zhang, Lan; Xie, Xiao-Yin; Ge, Ning; Li, Lixin; Zhang, Boheng; Ye, Sheng‐Long; Ren, Zhigang

doi:10.1371/journal.pone.0096072

Cited by 118 publications

(109 citation statements)

References 43 publications

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“…We set the optimum NLR threshold value as 5, as in previous reports of other cancers. 34 Of 105 patients, 82 (78%) patients had an NLR of < 5. The median OS after resection in the patients with an NLR of < 5 was 14 months, and the median OS of those with an NLR of ≥ 5 was 5 months (p = 0.01 according to the log-rank test; Fig.…”

Section: Resultsmentioning

confidence: 99%

“…Consistent with previous studies of advanced cancers, elevated NLR was a strong prognostic factor. 4,8,11,13,14,16,19,22,27,34 The role of the host inflammatory response in determining tumor spread is increasingly recognized. The association between elevated NLR and poor prognosis has several possible explanations.…”

Section: Figmentioning

confidence: 99%

“…15,35 A systematic inflammatory response leads to changes in the relative levels of circulating white blood cells, resulting in an increase in neutrophils and a decrease in lymphocytes with the progression of cancer. 25 Recently, an association was reported between a high neutrophil-to-lymphocyte ratio (NLR) and shorter survival time in patients with various cancers, 4,8,11,13,14,16,19,22,27,34 including glioblastoma. 3,12,18 However, the value of preoperative NLR in the assessment of candidates for resection for brain metastasis has not been evaluated.…”

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confidence: 99%

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Elevated preoperative neutrophil-to-lymphocyte ratio as a predictor of worse survival after resection in patients with brain metastasis

Mitsuya¹,

Nakasu²,

Kurakane

et al. 2017

Journal of Neurosurgery

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B rain metastases occur in 10% to 40% of patients with cancer and are the most common central nervous system neoplasm in adults. 28,33 With increased surveillance, improved control of systemic cancer, and prolonged survival, the incidence of patients with brain metastases is increasing. 17 The management of brain metastases has been revolutionized in clinical oncology by 4 developments: improved brain imaging, improved management of systemic diseases, the distribution of stereotactic irradiation, and the extension of less invasive surgical techniques that enable brain metastases to be removed even from eloquent brain areas with minimal morbidity. 5Although stereotactic irradiation and pharmacotherapies contribute to the treatment outcome of patients with brain metastasis, resection is still a mainstay for large brain metastases.The indications for resection include a symptomatic mass, a mass with considerable edema requiring high-dose ABBREVIATIONS DS-GPA = diagnosis-specific graded prognostic assessment; KPS = Karnofsky Performance Status; NLR = neutrophil-to-lymphocyte ratio; OS = overall survival; RPA = recursive partitioning analysis. SUBMITTED OBJECTIVEThe median postoperative survival duration of patients with brain metastases who undergo tumor resection is 12 months. Most of these patients die of systemic metastases or the progression of primary cancer but not brain metastases. The criteria for indicating resection are still controversial. Systemic assessment is restricted, especially in patients who need emergent management for their large-size or life-threatening brain metastases. The neutrophil-tolymphocyte ratio (NLR) is reported to correlate with survival time or progression-free survival in patients with various cancers. However, NLR has not been assessed in patients with brain metastases. The impact of NLR on the survival data of patients who had undergone resection of brain metastases was retrospectively analyzed. METHODS The clinical records of patients who underwent resection of brain metastases at Shizuoka Cancer Center between May 2007 and January 2015 were retrospectively analyzed. NLR was calculated by using the data obtained from the latest examination before resection and before the administration of steroid therapy. Kaplan-Meier curves were used for the assessment of overall survival (OS). RESULTS Of the 105 patients included, 67 patients were male. The median age of the patients was 63 years (range 36-90 years). The primary cancers were lung, colon, breast, uterus, and other cancers in 48, 19, 10, 8, and 20 patients, respectively. The postresection median survival duration was 12 months (range 1-91 months) for the entire series. The optimum NLR threshold value was identified as 5. A significant difference in the median OS was found: 14 months for 82 patients with an NLR < 5 versus 5 months for 23 patients with an NLR ≥ 5 (p = 0.001). CONCLUSIONS In this study, an elevated preoperative NLR is a predictor of worse survival after resection for brain metastases. NLR is a simple, systemic m...

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Section: Resultsmentioning

confidence: 99%

Section: Figmentioning

confidence: 99%

mentioning

confidence: 99%

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Elevated preoperative neutrophil-to-lymphocyte ratio as a predictor of worse survival after resection in patients with brain metastasis

Mitsuya¹,

Nakasu²,

Kurakane

et al. 2017

Journal of Neurosurgery

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“…Therefore, it is not surprising that neutrophils, a key inflammatory cell type, can be mobilized and recruited to tumors. In fact, aberrant accumulation of neutrophils has been documented in a wide variety of tumors and is often associated with poor clinical outcomes (4)(5)(6)(7)(8)(9)(10)(11). Emerging evidence also suggests that neutrophils, in response to signals derived from cancer cells or stromal cells, can alter their phenotypes and migration routes and also release factors that act on tumor cells and other cell types (e.g., endothelial cells and immune cells), which we review in the following sections.…”

Section: Introductionmentioning

confidence: 99%

The Complex Role of Neutrophils in Tumor Angiogenesis and Metastasis

Liang

Ferrara

2016

Cancer Immunology Research

298

224

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Chronic inflammation fosters cancer development and progression and also modulates tumor responses to anticancer therapies. Neutrophils are key effector cells in innate immunity and are known to play a critical role in various inflammatory disorders. However, the functions of neutrophils in cancer pathogenesis have been largely neglected until recently and still remain poorly characterized compared with other immune cells in the tumor microenvironment. We highlight recent findings on the mechanisms by which tumor cells, in cooperation with tumorassociated stromal cells, induce expansion, recruitment, and polarization of neutrophils. We also review the multifaceted roles that neutrophils play in different aspects of cancer development and progression, with an emphasis on tumor angiogenesis and metastasis.

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“…IBD is also characterized by microbiome and environmental factors which are still poorly understood. Some researchers have suggested that the systemic inflammatory response may modulate the host microbiome of IBD, and has received increased attention [23,24]. Lots of studies have indicated that effective and efficient therapy could significantly control clinical symptoms (extraintestinal manifestations), reduce relapse, maintain remission, and improve the quality of life [25][26][27].…”

Section: Discussionmentioning

confidence: 99%

Systemic inflammation response index (SIRI) as a predictor for predicting inflammatory bowel disease (IBD) severity

Yu¹,

Yu²,

Ou³

et al. 2018

biomedicalresearch

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Peripheral venous blood markers may reflect the systematic inflammatory response condition. Various indices have been used to evaluate Inflammatory Bowel Disease (IBD), however, there is no ideal maker to assess the IBD activity and severity. We aim to investigate the potential value of Systemic Inflammation Response Index (SIRI) in IBD patients, and use it to predict the disease activity and severity. We designed a retrospective study to evaluate the SIRI in estimating disease severity in patients with IBD. We enrolled 210 patients with IBD, included 110 cases of Ulcerative Colitis (UC) and 100 cases of Crohn's Disease (

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Prognostic Significance of the Neutrophil-to-Lymphocyte Ratio in Primary Liver Cancer: A Meta-Analysis

Cited by 118 publications

References 43 publications

Elevated preoperative neutrophil-to-lymphocyte ratio as a predictor of worse survival after resection in patients with brain metastasis

Elevated preoperative neutrophil-to-lymphocyte ratio as a predictor of worse survival after resection in patients with brain metastasis

The Complex Role of Neutrophils in Tumor Angiogenesis and Metastasis

Systemic inflammation response index (SIRI) as a predictor for predicting inflammatory bowel disease (IBD) severity

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