Prognostic significance of TRIM28 expression in patients with breast carcinoma

Zhang, Wen; Zheng-quan, Cai; Kong, Mingzhu; Wu, Anqi; Hu, Zeyang; Wang, Feng; Wang, Hua

doi:10.1515/med-2021-0263

Cited by 6 publications

(6 citation statements)

References 23 publications

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“…The dysregulation of BrD proteins has been repeatedly acknowledged in different types of cancer. TRIM28 overexpression in breast cancer was correlated with lymph node metastasis and shorter overall survival (OS) [15]. BRD4 was reported to be involved in the development of leukemia, prostate cancer, and breast cancer, as confirmed by BET-inhibitor (BETi) studies [16].…”

Section: Introductionmentioning

confidence: 93%

It Runs in the Bromodomain Family: Speckled Proteins (SP) Play a Role in the Antitumor Immune Response in Solid Tumors

Rosochowicz

Lipowicz

Karwacka

et al. 2022

IJMS

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Cells and immune cells in the extracellular matrix: Depending on the tumor type and variety of TAAs (tumor-associated antigens), immune infiltrates are composed of many different subpopulations of immune cells. Epigenetic changes are also considered to be characteristic of cancer. Epigenetic factors taking part in the regulation of gene expression include the VII group of bromodomain proteins (BrD)—SP-family proteins. Here, we used transcriptomic data from the TCGA database, as well as immunological evidence from ESTIMATE, TIP, and TIMER2.0 databases for various solid tumor types and harnessed several publicly available bioinformatic tools (such as GSEA and GSCA) to demonstrate mechanisms and interactions between BrD proteins and immune infiltrates in cancer. We present a consistently positive correlation between the SP-family genes and immune score regardless of the tumor type. The SP-family proteins correlate positively with T cells’ trafficking and infiltration into tumor. Our results also show an association between the high expression of SP family genes and enriched transcriptome profiles of inflammatory response and TNF-α signaling via NF-κβ. We also show that the SP-family proteins could be considered good predictors of high immune infiltration phenotypes.

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Section: Introductionmentioning

confidence: 93%

It Runs in the Bromodomain Family: Speckled Proteins (SP) Play a Role in the Antitumor Immune Response in Solid Tumors

Rosochowicz

Lipowicz

Karwacka

et al. 2022

IJMS

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“…Alteration of TRIM protein expression is suggestive of BC development. TRIM13, 215 TRIM21, 216 TRIM35, 214 TRIM58, 217 and TRIM62 169 are expressed at low levels in BC samples, whereas the expression of TRIM24, 218 TRIM28, 219,220 TRIM39, 211 TRIM44, 175 TRIM59, 221 and TRIM63 177 maintains high. Analyzing the relationship between TRIM expression and clinic‐pathological features of patients, members such as TRIM24, TRIM28, and TRIM59 are revealed further upregulated in the subtype of TNBC which is usually more aggressive.…”

Section: Potential Of Trims In Diagnosis and Drug Designsmentioning

confidence: 99%

“…212 Pathiraja et al observed that ectopic expression of TRIM24 in immortalized HMECs (TRIM24 iHMECs) would activate aerobic glycolysis as well as greatly increase glucose metabolism, and functionally promote the malignant biological behavior of BC. 213 TRIM58, 217 and TRIM62 169 are expressed at low levels in BC samples, whereas the expression of TRIM24, 218 TRIM28, 219,220 TRIM39, 211 TRIM44, 175 TRIM59, 221 and TRIM63 177 maintains high. Analyzing the relationship between TRIM expression and clinic-pathological features of patients, members such as TRIM24, TRIM28, and TRIM59 are revealed further upregulated in the subtype of TNBC which is usually more aggressive.…”

Section: Metabolic Reprogrammingmentioning

confidence: 99%

Emerging roles of tripartite motif family proteins (TRIMs) in breast cancer

Cao,

Yang,

Guo

et al. 2024

Cancer Medicine

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Breast cancer (BC) is the most common malignant tumor worldwide. Despite enormous progress made in the past decades, the underlying mechanisms of BC remain further illustrated. Recently, TRIM family proteins proved to be engaged in BC progression through regulating various aspects. Here we reviewed the structures and basic functions of TRIM family members and first classified them into three groups according to canonical polyubiquitination forms that they could mediate: K48‐ only, K63‐ only, and both K48‐ and K63‐linked ubiquitination. Afterwards, we focused on the specific biological functions and mechanisms of TRIMs in BCs, including tumorigenesis and invasiveness, drug sensitivity, tumor immune microenvironment (TIME), cell cycle, and metabolic reprogramming. We also explored the potential of TRIMs as novel biomarkers for predicting prognosis and future therapeutic targets in BC.

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“…The aberrant expression of the genes encoding bromodomain proteins has been frequently associated with a number of different types of cancer, often showing either a favorable or non-favorable prognostic value [ 49 , 50 , 51 , 52 , 53 , 54 , 55 ]. Global transcriptomic profiling via high-throughput RNA sequencing (RNA-seq) has proven to be a powerful method for classifying gene expression patterns, identifying biomarkers for disease classification and diagnosis, and uncovering candidate drug targets.…”

Section: Expression and Dependency Patterns Of Bromodomain Genes Across Cancermentioning

confidence: 99%

“…Thus, TRIM28 activity contributes to the development of several cancers. For example, TRIM28 is overexpressed in glioma [ 225 ], cervical cancer [ 226 ], lung cancer [ 227 ], hepatocellular carcinoma [ 228 ], and breast cancer [ 50 ]. Overexpression of TRIM28 is often associated with a more aggressive disease and poor patient outcomes, but it is unclear if bromodomain inhibition would be an effective therapeutic strategy since it does not appear to function as a canonical chromatin reader domain.…”

Section: An Interconnected Network Of Functional Groups In Bromodomain Proteinsmentioning

confidence: 99%

Functional Roles of Bromodomain Proteins in Cancer

Boyson

Gao

Quinn

et al. 2021

Cancers

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Histone acetylation is generally associated with an open chromatin configuration that facilitates many cellular processes including gene transcription, DNA repair, and DNA replication. Aberrant levels of histone lysine acetylation are associated with the development of cancer. Bromodomains represent a family of structurally well-characterized effector domains that recognize acetylated lysines in chromatin. As part of their fundamental reader activity, bromodomain-containing proteins play versatile roles in epigenetic regulation, and additional functional modules are often present in the same protein, or through the assembly of larger enzymatic complexes. Dysregulated gene expression, chromosomal translocations, and/or mutations in bromodomain-containing proteins have been correlated with poor patient outcomes in cancer. Thus, bromodomains have emerged as a highly tractable class of epigenetic targets due to their well-defined structural domains, and the increasing ease of designing or screening for molecules that modulate the reading process. Recent developments in pharmacological agents that target specific bromodomains has helped to understand the diverse mechanisms that bromodomains play with their interaction partners in a variety of chromatin processes, and provide the promise of applying bromodomain inhibitors into the clinical field of cancer treatment. In this review, we explore the expression and protein interactome profiles of bromodomain-containing proteins and discuss them in terms of functional groups. Furthermore, we highlight our current understanding of the roles of bromodomain-containing proteins in cancer, as well as emerging strategies to specifically target bromodomains, including combination therapies using bromodomain inhibitors alongside traditional therapeutic approaches designed to re-program tumorigenesis and metastasis.

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Prognostic significance of TRIM28 expression in patients with breast carcinoma

Cited by 6 publications

References 23 publications

It Runs in the Bromodomain Family: Speckled Proteins (SP) Play a Role in the Antitumor Immune Response in Solid Tumors

It Runs in the Bromodomain Family: Speckled Proteins (SP) Play a Role in the Antitumor Immune Response in Solid Tumors

Emerging roles of tripartite motif family proteins (TRIMs) in breast cancer

Functional Roles of Bromodomain Proteins in Cancer

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