Prognostic Usefulness of Sentinel Lymph Node Biopsy for Patients Who Have Clinically Node Negative, Localized, Primary Invasive Cutaneous Melanoma

Rhodes, Arthur R.

doi:10.1001/archdermatol.2010.371

Cited by 17 publications

(12 citation statements)

References 80 publications

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“…Despite the small number of patients in our cohort, our results confirm previous studies on SLN analysis in melanoma [3,4,8-11], in terms of SLN identification rate (97%), percentage of SLN positive patients (22%) and percentage of additional positive CLND (25%). We also observed a significant association between positive SLN and primary tumor thickness and microscopic ulceration.…”

Section: Discussionsupporting

confidence: 89%

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Sentinel lymph node biopsy in melanoma: Our 8-year clinical experience in a single French institute (2002–2009)

et al. 2012

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BackgroundSince the introduction of sentinel lymph node biopsy (SLNB), its use as a standard of care for patients with clinically node-negative cutaneous melanoma remains controversial. We wished to evaluate our experience of SLNB for melanoma.MethodsA single center observational cohort of 203 melanoma patients with a primary cutaneous melanoma (tumour thickness > 1 mm) and without clinical evidence of metastasis was investigated from 2002 to 2009. Head and neck melanoma were excluded. SLN was identified following preoperative lymphoscintigraphy and intraoperative gamma probe interrogation.ResultsThe SLN identification rate was 97%. The SLN was tumor positive in 44 patients (22%). Positive SLN was significantly associated with primary tumor thickness and microscopic ulceration. The median follow-up was 39.5 (5–97) months. Disease progression was significantly more frequent in SLN positive patients (32% vs 13%, p = 0.002). Five-year DFS and OS of the entire cohort were 79.6% and 84.6%, respectively, with a statistical significant difference between SLN positive (58.7% and 69.7%) and SLN negative (85% and 90.3%) patients (p = 0.0006 and p = 0.0096 respectively). Postoperative complications after SLNB were observed in 12% of patients.ConclusionOur data confirm previous studies and support the clinical usefulness of SLNB as a reliable and accurate staging method in patients with cutaneous melanoma. However, the benefit of additional CLND in patients with positive SLN remains to be demonstrated.

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Section: Discussionsupporting

confidence: 89%

“…In our study, the number of false-negative (10/153 = 6.5%) was similar (3-8%) to other studies [11,16,17]. However, there is ongoing debate on how to correctly calculate the false-negative rate.…”

Section: Discussionsupporting

confidence: 88%

Sentinel lymph node biopsy in melanoma: Our 8-year clinical experience in a single French institute (2002–2009)

et al. 2012

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“…In 2011, a Bayesian analysis reaffirmed the lack of prognostic value of SNB status in thick melanoma. 18 In contrast, multiple studies have demonstrated that the status of the sentinel lymph node is predictive of survival with node-negative patients having a 5-year survival of 56-71% versus 26-48% with node-positive disease. [30][31][32][33][34] In a recent metaanalysis by Rondelli et al, 35 and colleagues SNB status was predictive of survival with a 71% 5-year survival if node(s) was negative for disease and 39% if positive.…”

Section: Discussionmentioning

confidence: 98%

“…Several studies and a Bayesian analysis reported no prognostic value to SNB for thick melanoma. [16][17][18] In contrast, multiple other studies have demonstrated a predictive value for SNB in thick melanoma. [19][20][21][22][23][24] The therapeutic value of SNB for thick melanoma is also unclear.…”

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confidence: 91%

Sentinel lymph node biopsy is prognostic but not therapeutic for thick melanoma

Kachare

Singla

Vohra

et al. 2015

Surgery

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“…The results presented by Vermeeren et al 13 suggest that the only relevant prognostic factor regarding patients with thick melanoma is SNB and this procedure can be used to stratify patients according to the risk of recurrence. Conversely, Rhodes 14 and Oliveira Filho et al, 15 stated that SNB status does not contribute with relevant prognostic information in patients with thick melanoma and, therefore, SNB should not be recommended due to the lack of prognostic information.…”

Section: Introductionmentioning

confidence: 99%

Biópsia do Gânglio Sentinela em Melanomas Espessos: Estudo Clínico Retrospectivo num Único Centro

Lemos

Vieira

Brinca

et al. 2016

SPDV

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RESUMO -Introdução:A biopsia do gânglio sentinela é um procedimento genericamente aceite no estdiamento do melanoma. O valor prognóstico desta técnica parece ser mais relevante nos melanomas de espessura intermédia (1-4mm) do que nos melanomas espessos (>4mm). Objectivo: Avaliar o valor prognóstico do estado do gânglio sentinela em doentes com melanoma espesso. Doentes e Métodos: A sobrevivência livre de doença e a sobrevivência global foram estimadas pelo método de Kaplan-Meier e por um modelo de regressão de Cox numa amostra de doentes com melanoma espesso. Resultados: Foram incluídos 43 doentes (52.2% do sexo masculino) com uma média etária de 63,9 anos. A biopsia do gânglio sentinela foi positiva em 20 casos (46,5%). O tempo médio de seguimento foi de 40 meses. Os doentes em que não foram encontradas metástases no gânglio sentinela tiveram uma sobrevivência livre de doença aos 5 anos significativamente maior do que o grupo de doentes com gânglio sentinela positivo (63% versus 19%, p<0.05). A sobrevivência global aos 5 anos foi tendencialmente mais baixa em doentes com gânglio sentinela positivo (52% versus 79%), embora sem significado estatístico. Conclusão: O estado do gânglio sentinela não teve influência estatística na sobrevivência global dos doentes da nossa série de melanomas espessos, provavelmente devido ao risco elevado de metastização por via hemática. Porém, a biopsia do gânglio sentinela forneceu informação prognóstica relevante, uma vez que teve clara influência na sobrevivência livre de doença. PALAVRAS-CHAVE -Biópsia do Gânglio Sentinela; Melanoma; Neoplasias da Pele; Prognóstico; Taxa de Sobrevida. Sentinel Lymph Node Biopsy in Thick Melanoma

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Prognostic Usefulness of Sentinel Lymph Node Biopsy for Patients Who Have Clinically Node Negative, Localized, Primary Invasive Cutaneous Melanoma

Cited by 17 publications

References 80 publications

Sentinel lymph node biopsy in melanoma: Our 8-year clinical experience in a single French institute (2002–2009)

Sentinel lymph node biopsy in melanoma: Our 8-year clinical experience in a single French institute (2002–2009)

Sentinel lymph node biopsy is prognostic but not therapeutic for thick melanoma

Biópsia do Gânglio Sentinela em Melanomas Espessos: Estudo Clínico Retrospectivo num Único Centro

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