Prognostic value and oncogene function of heterogeneous nuclear ribonucleoprotein A1 overexpression in HBV-related hepatocellular carcinoma

Ke, Ruisheng; Zhang, Kun; Liu, Lizhi; Dong, Yi; Fan, Ping; Yang, Fang; Cai, Qiucheng; Jiang, Yi

doi:10.1016/j.ijbiomac.2019.02.012

Cited by 23 publications

(20 citation statements)

References 36 publications

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“…CHST4 expression was found to be related to viral gene expression, and thus, low CHST4 expression may promote HBV expression and replication in HCC, thereby increasing chromosomal instability and tumor cell proliferation, as reported previously (6). We also discovered that CHST4 participates in ribonucleoprotein complex biogenesis, RNA splicing, and mRNA metabolic process, and these biological processes have previously been implicated in HCC development (50,51). Moreover, ribosome biogenesis and mutations of ribosome genes were previously shown to be related to progression of various tumors (52,53).…”

Section: Discussionsupporting

confidence: 79%

Carbohydrate Sulfotransferase 4 Inhibits the Progression of Hepatitis B Virus-Related Hepatocellular Carcinoma and Is a Potential Prognostic Marker in Several Tumors

et al. 2020

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Carbohydrate sulfotransferase 4 (CHST4) plays an important role in lymphocyte homing and is abnormally expressed in several cancer types; however, its precise function in tumor development and progression is unknown. Here we confirm that CHST4 is aberrantly expressed in various tumor subtypes. In particular, we found that CHST4 expression was downregulated in hepatitis B virus-related hepatocellular carcinoma (HBV-HCC) tumors compared to paired normal tissue. We also showed that CHST4 overexpression inhibited the proliferation and metastasis of HCC cells in vitro. Clinically, CHST4 was identified as an independent prognostic factor for HBV-HCC patients. We further illuminated the anti-tumor role and mechanism of CHST4 in HBV-HCC by constructing a FENDRR-miR-10b-5p-CHST4 competing endogenous RNA network. We found that downregulation of CHST4 expression may promote HBV expression and regulate ribonucleoprotein complex biogenesis to promote malignant behaviors in HBV-HCC. CHST4 may also recruit CD4+ T cells, macrophages, dendritic cells, and neutrophils into the tumor microenvironment to inhibit the progression of HBV-HCC. Overall, our findings suggest that CHST4 acts as a tumor suppressor in HCC-HBV and represents a potential diagnostic and therapeutic target.

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Section: Discussionsupporting

confidence: 79%

Carbohydrate Sulfotransferase 4 Inhibits the Progression of Hepatitis B Virus-Related Hepatocellular Carcinoma and Is a Potential Prognostic Marker in Several Tumors

et al. 2020

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“…Abnormality in RNA splicing have been associated with tumor initiation and progression [26,27]. The ribonucleoprotein complex involved in initiation, progression and prognosis of cancer [28,29]. In addition, in cancer cells, lncRNA were aberrantly expressed as classical oncogenes or tumor suppressors and correlate with the altered metabolism [30,31].…”

Section: Discussionmentioning

confidence: 99%

Identification and Validation of an RNA Binding Proteins-Associated Prognostic Signature for Non-Small Cell Lung Cancer

Miao¹,

Chen

Xiao

et al. 2020

Preprint

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Background: Non-small cell lung cancer (NSCLC) is a malignancy with relatively high incidence and poor prognosis. RNA-binding proteins (RBPs) were reported to be dysregulated in multiple cancers and were closely associated with tumor initiation and progression. However, the functions of RBPs in NSCLC remain unclear. Method: The RNA sequencing data and corresponding clinical information of NSCLC was downloaded from The Cancer Genome Atlas (TCGA) database. We identified aberrantly expressed RBPs between tumor and control tissue, and systemically investigated the expression and prognostic value of these RBPs by a series of bioinformatics analysis.Results: A total of 459 aberrantly expressed RBPs (291 up-regulated and 168 down-regulated RBPs) were identified. Functional enrichment analysis indicated that the differentially expressed RBPs were mainly associated with RNA splicing, ncRNA metabolic process, regulation of translation, mRNA surveillance pathway, RNA degradation, and RNA transport. Thirteen RBPs (ZC3H12C, ZC3H12D, BOP1, CASC3, DDX24, IGF2BP1, KHDC1, FASTKD3, TARBP1, INTS7, NOL12, SNRPB, PABPC1L) were identified as prognostic RBPs by multivariate Cox regression analysis, and were used to construct a prognostic signature. Further analysis demonstrated that high-risk group were significantly related to poor overall survival in training and testing cohort. The area under receiver operator characteristic curve of the prognostic signature was 0.703 in training cohort and 0.636 in testing cohort. In addition, the prognostic signature was further validated in differently clinical subgroup (>=65, <65, female, male, stage I-II, III- IV, T1-2, T3-4, N0, N1-3, M0 and M1). The risk score was an independent prognostic factor of NSCLC. A nomogram based on thirteen RBPs was constructed to predict the survival of patients.Conclusion: Our results provide novel insights into the pathogenesis of NSCLC. The RBPs-associated prognostic signature showed predictive value for NSCLC prognosis, with potential applications in clinical decision-making and individualized treatment.

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“…This is typically illustrated by the regulation of TTP by the lncRNA Linc-SCRG1 in LX2 stellate cells [ 64 ], or of RBM38 by the lncRNA HOTAIR in HCC cells [ 65 ]. Numerous miRNAs are also bioinformatically predicted to target AUBPs, with some of them having been experimentally validated in specific conditions, i.e., HNRNPA1 targeting by miR-22 [ 66 ], CUGBP2 targeting by miR-95 [ 67 ], and YB-1 targeting by miR-148a [ 68 ].…”

Section: Au-rich Element-binding Proteinsmentioning

confidence: 99%

“…It is therefore likely that alterations of the expression, activity, or intracellular localization of AUBPs represent key drivers of hepatic carcinogenesis. AUBPs such as TTP are constantly downregulated in HCC [ 86 , 125 ], while most of the other AUBPs are usually upregulated (i.e., HNRNPA1, PTBP1, RBM3, ILF3, or TIA1), a feature that often correlates with a worse survival prognosis [ 66 , 126 , 127 , 128 , 129 ]. In the following section, recent advances in our understanding of the role of AUBPs in key cancer hallmarks are discussed.…”

Section: Aubps In the Hallmarks Of Liver Cancermentioning

confidence: 99%

“…Additionally, by binding to the 3’-UTR of stearoyl-CoA desaturase (SCD), RBM3 induces the expression of a circRNA, SCD-circRNA 2, in HCC cells, which promotes proliferation, possibly through ERK phosphorylation [ 127 ]. Finally, based on gene set enrichment analysis, the high expression of HNRNPA1 in HBV-related HCC has been suggested to affect cell cycle progression and the WNT signaling pathway, pointing to HRNPA1 as a potent oncogene regulating the epidermal growth factor receptor (EGFR) signaling pathway [ 66 ].…”

Section: Aubps In the Hallmarks Of Liver Cancermentioning

confidence: 99%

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mRNA Post-Transcriptional Regulation by AU-Rich Element-Binding Proteins in Liver Inflammation and Cancer

Dolicka

Sobolewski

Sousa

et al. 2020

IJMS

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AU-rich element-binding proteins (AUBPs) represent important post-transcriptional regulators of gene expression. AUBPs can bind to the AU-rich elements present in the 3’-UTR of more than 8% of all mRNAs and are thereby able to control the stability and/or translation of numerous target mRNAs. The regulation of the stability and the translation of mRNA transcripts by AUBPs are highly complex processes that occur through multiple mechanisms depending on the cell type and the cellular context. While AUBPs have been shown to be involved in inflammatory processes and the development of various cancers, their important role and function in the development of chronic metabolic and inflammatory fatty liver diseases (FLDs), as well as in the progression of these disorders toward cancers such as hepatocellular carcinoma (HCC), has recently started to emerge. Alterations of either the expression or activity of AUBPs are indeed significantly associated with FLDs and HCC, and accumulating evidence indicates that several AUBPs are deeply involved in a significant number of cellular processes governing hepatic metabolic disorders, inflammation, fibrosis, and carcinogenesis. Herein, we discuss our current knowledge of the roles and functions of AUBPs in liver diseases and cancer. The relevance of AUBPs as potential biomarkers for different stages of FLD and HCC, or as therapeutic targets for these diseases, are also highlighted.

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Prognostic value and oncogene function of heterogeneous nuclear ribonucleoprotein A1 overexpression in HBV-related hepatocellular carcinoma

Cited by 23 publications

References 36 publications

Carbohydrate Sulfotransferase 4 Inhibits the Progression of Hepatitis B Virus-Related Hepatocellular Carcinoma and Is a Potential Prognostic Marker in Several Tumors

Carbohydrate Sulfotransferase 4 Inhibits the Progression of Hepatitis B Virus-Related Hepatocellular Carcinoma and Is a Potential Prognostic Marker in Several Tumors

Identification and Validation of an RNA Binding Proteins-Associated Prognostic Signature for Non-Small Cell Lung Cancer

mRNA Post-Transcriptional Regulation by AU-Rich Element-Binding Proteins in Liver Inflammation and Cancer

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