Prognostic value and therapeutic consequences of vascular invasion in non-small cell lung carcinoma

Bodendorf, Marc Oliver; Haas, Victor H.; Laberke, H. D.; Blumenstock, Gunnar; Wex, Peter; Graeter, Thomas

doi:10.1016/j.lungcan.2008.07.011

Cited by 43 publications

(26 citation statements)

References 33 publications

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“…The pathologic stage of nine cases in this study was upstaged by the help of elastic stain. Lymphatic vessel invasion was shown as a significant determinant for survival in a number of reports [4,[16][17][18] whereas the prognostic relevance of blood vessel invasion (BVI) remains controversial [4,11,18,19]. In another study only venous invasion (but not arterial) was related with poor outcome [20].…”

Section: Discussionmentioning

confidence: 99%

Clinical impact of visceral pleural, lymphovascular and perineural invasion in completely resected non-small cell lung cancer

Yılmaz¹,

Duyar²,

Çakır³

et al. 2011

European Journal of Cardio-Thoracic Surgery

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Section: Discussionmentioning

confidence: 99%

Clinical impact of visceral pleural, lymphovascular and perineural invasion in completely resected non-small cell lung cancer

Yılmaz¹,

Duyar²,

Çakır³

et al. 2011

European Journal of Cardio-Thoracic Surgery

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“…ALI, covering Ly and V, is considered to represent a useful prognostic factor in all stages of NSCLC [13,14]. In addition, even in the early stages represented by node-negative (pathological stage I) NSCLC, some reports have found that ALI status can predict early mortality [5][6][7][8].…”

Section: Discussionmentioning

confidence: 99%

Angiolymphatic invasion exerts a strong impact on surgical outcomes for stage I lung adenocarcinoma, but not non-adenocarcinoma

et al. 2012

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“…BVI has been suggested to be a significant prognostic indicator for various types of carcinomas of the stomach, colon, uterus, breast, and lung [14][15][16][17][18]. As for GIST, the liver is one of the most common sites of metastasis, whereas lymph node metastasis is very rare [19,20], leading us to hypothesize that GIST cells mainly infiltrate into blood vessels rather than lymphatic vessels, and preferentially metastasize to the liver (hematogenic metastasis).…”

Section: Introductionmentioning

confidence: 99%

Prognostic impact of blood vessel invasion in gastrointestinal stromal tumor of the stomach

et al. 2010

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Gastrointestinal stromal tumors have a wide spectrum of biologic behavior, and occasional cases show liver metastases. The modified risk grade based on tumor size and mitotic counts has been proposed to predict the biologic behavior in gastric gastrointestinal stromal tumors. Blood vessel invasion (BVI) is important in the development of metastasis of various kinds of cancer. The aim of this study was to elucidate the potential role of blood vessel invasion in gastric gastrointestinal stromal tumors. Blood vessel invasion was found in 17 of 122 cases (13.9%) of gastrointestinal stromal tumors, and was significantly correlated with larger tumor size, higher mitotic count and higher modified risk grade. Among 83 cases of primary, localized gastric gastrointestinal stromal tumors available for follow-up information, liver metastasis was observed in 14 cases (16.9%). When blood vessel invasion was positive in the primary tumor, liver metastasis occurred in 80% of cases after the initial surgery, indicating that blood vessel invasion was a significant risk factor of liver metastasis (P < .0001). In univariate and multivariate analyses, tumor size (>5 cm), mitotic count (>5/50 high-power fields) and blood vessel invasion (positive) were significantly associated with a shorter period of disease-free survival. Our results suggest that the evaluation of blood vessel invasion may be useful for predicting the risk of liver metastasis and aggressive biologic behavior of gastrointestinal stromal tumors, and may serve as important information for determining the therapeutic strategies including adjuvant molecular target therapy.

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Prognostic value and therapeutic consequences of vascular invasion in non-small cell lung carcinoma

Cited by 43 publications

References 33 publications

Clinical impact of visceral pleural, lymphovascular and perineural invasion in completely resected non-small cell lung cancer

Clinical impact of visceral pleural, lymphovascular and perineural invasion in completely resected non-small cell lung cancer

Angiolymphatic invasion exerts a strong impact on surgical outcomes for stage I lung adenocarcinoma, but not non-adenocarcinoma

Prognostic impact of blood vessel invasion in gastrointestinal stromal tumor of the stomach

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