Prognostic value of 18F-FDG PET/CT functional parameters in patients with head and neck cancer

Wang, Lihong; Bai, Jian; Duan, Ping

doi:10.1097/mnm.0000000000000974

Cited by 28 publications

(21 citation statements)

References 47 publications

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“…MTV and TLG were introduced in HNC as tools to improve the prognostic stratification and to support other PET/CT-guided radiotherapy plan [18, 19, 23]. These quantitative parameters were analyzed in several series of oropharynx squamous cell carcinoma, and, recently, Wang et al in a meta-analysis confirmed their superiority compared to SUVmax, highlighting MTV and TLG as prognostic biomarkers to predict outcome in patients with head and neck cancer [59]. Kendi et al evaluated PET/CT parameters impact to differentiate invasion and penetration of thyroid cartilage highlighting that TLG and MTV had enough power to predict thyroid cartilage invasion and penetration in irradiated patients.…”

Section: Discussionmentioning

confidence: 99%

¹⁸F-FDG-PET/CT Imaging in Advanced Glottic Cancer: A Tool for Clinical Decision in Comparison with Conventional Imaging

Paone

Martucci

Espeli

et al. 2019

Contrast Media & Molecular Imaging

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This study assessed the role of 18F-FDG PET-CT (PET/CT) to detect the cartilage and paraglottic infiltration in advanced glottic cancer comparing the results with those of conventional imaging (CI) (contrast-enhanced computed tomography and/or magnetic resonance). In addition, we assessed the prognostic value of quantitative parameters, measured on baseline PET/CT, in terms of event-free survival (EFS) and overall survival (OS). We retrospectively analyzed 27 patients with glottic squamous cell carcinoma stage III and IVA, treated in our institute between 2010 and 2016, comparing PET/CT, performed for staging and radiotherapy planning, and CI findings. Cohen’s K was used to compare concordance between PET/CT and CI. Imaging findings were correlated with endoscopic evaluation and histological reports (gold standard (GS)). All lesions shown by CI were also detected by PET/CT imaging, and in 5 cases, a better definition of local infiltration was achieved with PET/CT than CI (5 CT). Sensitivity, specificity, and accuracy of PET/CT and CT were 95%, 86%, and 93% and 70%, 86%, and 74% for, respectively. MRI showed sensitivity and specificity of 100%. One false-negative (FN) cases and 1 false-positive (FP) case were observed with PET/CT with no difference compared to MRI (10 cases). Six FN cases and 1 FP case were observed with CT. Cohen’s K was 0.60 (PET vs. CI) and 0.80 (PET vs. GS). Patients were followed-up for at least 24 months to calculate EFS and OS. 13 local recurrence and 7 deaths were recorded. Among quantitative PET parameters, baseline MTV was the most powerful predictor of outcome. Our data suggest a reliable sensitivity and accuracy of PET/CT in the evaluation of local extension, proving a useful method for initial local staging in addition to the well-established role in lymph-node and distant sites assessment. Furthermore, pretreatment MTV provides better prognostic information than other PET/CT parameters.

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Section: Discussionmentioning

confidence: 99%

¹⁸F-FDG-PET/CT Imaging in Advanced Glottic Cancer: A Tool for Clinical Decision in Comparison with Conventional Imaging

Paone

Martucci

Espeli

et al. 2019

Contrast Media & Molecular Imaging

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“…Then feature extraction was performed using LIFEx (IMIV, CEA, France) based on these regions of interest (ROIs) [21]. Maximum standardized uptake value (SUVmax), peak standardized uptake value (SUVpeak), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) are the conventional metabolic or metabolic-volumetric parameters which are the most extensively studied in the previous studies and found to be prognostic in head and neck cancer [22–24]. Among the many heterogeneity parameters, we selected entropy and coefficient of variation (COV) because these features were reproducible and robust values in different reconstruction and acquisition time settings according to previous studies [25, 26].…”

Section: Methodsmentioning

confidence: 99%

Association of metabolic and genetic heterogeneity in head and neck squamous cell carcinoma with prognostic implications: integration of FDG PET and genomic analysis

Choi

Gim

et al. 2019

EJNMMI Res

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PurposeThe linkage between the genetic and phenotypic heterogeneity of the tumor has not been thoroughly evaluated. Herein, we investigated how the genetic and metabolic heterogeneity features of the tumor are associated with each other in head and neck squamous cell carcinoma (HNSC). We further assessed the prognostic significance of those features.MethodsThe mutant-allele tumor heterogeneity (MATH) score (n = 508), a genetic heterogeneity feature, and tumor glycolysis feature (GlycoS) (n = 503) were obtained from the HNSC dataset in the cancer genome atlas (TCGA). We identified matching patients (n = 33) who underwent 18F-fluorodeoxyglucose positron emission tomography (FDG PET) from the cancer imaging archive (TCIA) and obtained the following information from the primary tumor: metabolic, metabolic-volumetric, and metabolic heterogeneity features. The association between the genetic and metabolic features and their prognostic values were assessed.ResultsTumor metabolic heterogeneity and metabolic-volumetric features showed a mild degree of association with MATH (n = 25, ρ = 0.4~0.5, P < 0.05 for all features). The patients with higher FDG PET features and MATH died sooner. Combination of MATH and tumor metabolic heterogeneity features showed a better stratification of prognosis than MATH. Also, higher MATH and GlycoS were associated with significantly worse overall survival (n = 499, P = 0.002 and 0.0001 for MATH and GlycoS, respectively). Furthermore, both MATH and GlycoS independently predicted overall survival after adjusting for clinicopathologic features and the other (P = 0.015 and 0.006, respectively).ConclusionBoth tumor metabolic heterogeneity and metabolic-volumetric features assessed by FDG PET showed a mild degree of association with genetic heterogeneity in HNSC. Both metabolic and genetic heterogeneity features were predictive of survival and there was an additive prognostic value when the metabolic and genetic heterogeneity features were combined. Also, MATH and GlycoS were independent prognostic factors in HNSC; they can be used for precise prognostication once validated.

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“…Other groups have further evaluated this concept, using alternative diagnostic imaging modalities, such as magnetic resonance Imaging (MRI), positron emission tomography (PET)/CT, and single-photon emission computed tomography (SPECT)/CT, and analyzing endpoints, such as metabolic tumor volume (MTV), maximum standardized uptake values (maxSUV), and total lesion glycolysis (TLG) as tools for better treatment selection [ 54 ].…”

Section: Locally Advanced Stage (Iii–iv)mentioning

confidence: 99%

Emerging Concepts and Novel Strategies in Radiation Therapy for Laryngeal Cancer Management

Gamez

Blakaj

Zoller

et al. 2020

Cancers

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Laryngeal squamous cell carcinoma is the second most common head and neck cancer. Its pathogenesis is strongly associated with smoking. The management of this disease is challenging and mandates multidisciplinary care. Currently, accepted treatment modalities include surgery, radiation therapy, and chemotherapy—all focused on improving survival while preserving organ function. Despite changes in smoking patterns resulting in a declining incidence of laryngeal cancer, the overall outcomes for this disease have not improved in the recent past, likely due to changes in treatment patterns and treatment-related toxicities. Here, we review emerging concepts and novel strategies in the use of radiation therapy in the management of laryngeal squamous cell carcinoma that could improve the relationship between tumor control and normal tissue damage (therapeutic ratio).

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Prognostic value of 18F-FDG PET/CT functional parameters in patients with head and neck cancer

Cited by 28 publications

References 47 publications

¹⁸F-FDG-PET/CT Imaging in Advanced Glottic Cancer: A Tool for Clinical Decision in Comparison with Conventional Imaging

¹⁸F-FDG-PET/CT Imaging in Advanced Glottic Cancer: A Tool for Clinical Decision in Comparison with Conventional Imaging

Association of metabolic and genetic heterogeneity in head and neck squamous cell carcinoma with prognostic implications: integration of FDG PET and genomic analysis

Emerging Concepts and Novel Strategies in Radiation Therapy for Laryngeal Cancer Management

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Prognostic value of 18F-FDG PET/CT functional parameters in patients with head and neck cancer

Cited by 28 publications

References 47 publications

18F-FDG-PET/CT Imaging in Advanced Glottic Cancer: A Tool for Clinical Decision in Comparison with Conventional Imaging

18F-FDG-PET/CT Imaging in Advanced Glottic Cancer: A Tool for Clinical Decision in Comparison with Conventional Imaging

Association of metabolic and genetic heterogeneity in head and neck squamous cell carcinoma with prognostic implications: integration of FDG PET and genomic analysis

Emerging Concepts and Novel Strategies in Radiation Therapy for Laryngeal Cancer Management

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Product

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¹⁸F-FDG-PET/CT Imaging in Advanced Glottic Cancer: A Tool for Clinical Decision in Comparison with Conventional Imaging

¹⁸F-FDG-PET/CT Imaging in Advanced Glottic Cancer: A Tool for Clinical Decision in Comparison with Conventional Imaging