Prognostic value of adenosine stress myocardial perfusion by cardiac magnetic resonance imaging in patients with known or suspected coronary artery disease

Lo, KL; Leung, K.; Chu, Chung Ming; Loke, K.L.; Chan, Chung-hong; Yue, Chiu Sun

doi:10.1093/qjmed/hcq238

Cited by 16 publications

(13 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[20][21][22][23]26,30 Of the 13 series of patients included for subanalysis using the criterion to define the test as negative, 7 used the absence of inducible PDs [20][21][22]27,[29][30][31] as the criterion to define a negative test; of these studies, 1 used dipyridamole as the stressor, 4 used adenosine, and 2 used a stress protocol with both dipyridamole and adenosine. In the remaining 6 series of patients, the definition of a negative study was based on the absence of inducible ; of these, 1 used dipyridamole and 5 used dobutamine as the stressor.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

The Prognostic Value of Normal Stress Cardiac Magnetic Resonance in Patients With Known or Suspected Coronary Artery Disease

Gargiulo

Dellegrottaglie

Bruzzese

et al. 2013

Circ: Cardiovascular Imaging

View full text Add to dashboard Cite

Background— Ischemia detection with stress cardiac magnetic resonance (CMR) is typically based on induction of either myocardial perfusion defect or wall motion abnormality. Single-center studies have shown the high value of stress CMR for risk stratification. The aim of this study was to define the prognostic value of stress CMR for prediction of adverse cardiac events in patients with known or suspected coronary artery disease. Methods and Results— Studies published between January 1985 and April 2012 were identified by database search. We included studies using stress CMR to evaluate subjects with known or suspected coronary artery disease and providing primary data on clinical outcomes of nonfatal myocardial infarction or cardiac death with a follow-up time ≥3 months. Total of 14 studies were finally included, recruiting 12 178 patients. The negative predictive value for nonfatal myocardial infarction and cardiac death of normal CMR was 98.12% (95% confidence interval, 97.26–98.83) during a weighted mean follow-up of 25.3 months, resulting in estimated event rate after a negative test equal to 1.88% (95% confidence interval, 1.17–2.74). The corresponding annualized event rate after a negative test was 1.03%. Comparable negative predictive values for major coronary events were obtained in studies considering the absence of inducible perfusion defect compared with those evaluating the absence of inducible wall motion abnormality (98.39% versus 97.31%, respectively; P =0.227 by meta-regression analysis). Conclusions— Stress CMR has a high negative predictive value for adverse cardiac events, and the absence of inducible perfusion defect or wall motion abnormality shows a similar ability to identify low-risk patients with known or suspected coronary artery disease.

show abstract

Section: Resultsmentioning

confidence: 99%

“…20,[26][27][28][29][30] Figure 4 shows the forest plot of the NPV and ERNT for each study, as well as the pooled estimates yielded by the random-effect model (I 2 =94.7%; P<0.001). The individual NPVs ranged from 75.27% to 100%.…”

Section: Predictive Value Of Stress Cmr For Myocardial Revascularizatmentioning

confidence: 99%

The Prognostic Value of Normal Stress Cardiac Magnetic Resonance in Patients With Known or Suspected Coronary Artery Disease

Gargiulo

Dellegrottaglie

Bruzzese

et al. 2013

Circ: Cardiovascular Imaging

View full text Add to dashboard Cite

show abstract

“…The specificity and diagnostic accuracy of both methods were low because both MPS and Stress Echo procedures are ischemia imaging protocols and angiography as a gold standard causes increase in false positive results. However the positive ischemia finding to be an independent predictor of cardiac events according to approximately four years follow up of 203 patients in a previous study [17]. Additionally parameters obtained from cardiac MRI like adenosine stress perfusion, delayed enhancement, and left ventricular function has been observed to provide information regarding prognostification in another study [18].…”

Section: Discussionmentioning

confidence: 88%

Adenosine Stress Myocardial Perfusion Scintigraphy and Echocardiography Application with Same Infusion

Pinar¹,

Dağlı²,

Ansal³

et al. 2017

Int J Clin Cardiol

View full text Add to dashboard Cite

Objective: Stress Echocardiography (Echo) and Myocardial Perfusion Scintigraphy (MPS) are effective methods for identification of myocardial ischemia. Aim of this study was to compare adenosine stress MPS and Echo results with gold standard angiography. Methods:Twenty nine patients (18 F, 11 M; mean: 49, 62 ± 10, 9; 45, 5-53, 8-years-old) with suspicion of Coronary Artery Disease (CAD) were included into the study. After performance of basal Echo examination, adenosine infusion was started (140 µgr/kg/dk) and at the third minute after starting the infusion, intravenous Tc-99m MIBI injection was performed and stress Echo findings were recorded at the 10 th minute. Stress and rest imaging were performed at the same day. Stress Echo was performed by an experienced cardiologist and MPS results were interpreted by an experienced nuclear medicine physician who didn't know stress Echo results according to 17 segment models. Sixteen patients underwent coronary angiography. Ischemia territory size in both the adenosine stress Echo and MPS were recorded and compared in segment and in patient basis.Results: There were 34 ischemic segments in MPS and 46 in stress Echo among 493 segments of 29 patients. Both MPS and stress Echo pointed the same ischemic segments in 9 patients and tests were in agreement in 24 patients. Angiography confirmed two tests results in 13/16 patients. Three patients with severe ischemia in the MPS and stress Echo had slow flow pattern in the angiography. Conclusion:The results of both MPS and stress Echo with same adenosine infusion was in agreement especially in patients with angiography results. These findings can encourage simultaneous studies with same stress agent infusion.

show abstract

“…A recent meta-analysis has shown that this technique has sensitivity and specificity of 91% and 81% respectively for detection of CAD in patients presenting with subacute/acute chest pain [64]. Similar to other stress modalities, a negative study has good prognostic outlook [65,66]. Jahnke et al evaluated 513 patients with a combined myocardial perfusion and Dobutamine CMR examination and report event free survival rates of 99.3% at three years in patients with a negative result as compared to 83.5% with a positive scan [53].…”

Section: Concurrent Assessment Of Perfusion and Viabilitymentioning

confidence: 99%

Myocardial Viability Imaging: Does It Still Have a Role in Patient Selection Prior to Coronary Revascularisation?

Grover

Srinivasan

Selvanayagam

2012

Heart, Lung and Circulation

View full text Add to dashboard Cite

Prognostic value of adenosine stress myocardial perfusion by cardiac magnetic resonance imaging in patients with known or suspected coronary artery disease

Cited by 16 publications

References 21 publications

The Prognostic Value of Normal Stress Cardiac Magnetic Resonance in Patients With Known or Suspected Coronary Artery Disease

The Prognostic Value of Normal Stress Cardiac Magnetic Resonance in Patients With Known or Suspected Coronary Artery Disease

Adenosine Stress Myocardial Perfusion Scintigraphy and Echocardiography Application with Same Infusion

Myocardial Viability Imaging: Does It Still Have a Role in Patient Selection Prior to Coronary Revascularisation?

Contact Info

Product

Resources

About