Prognostic Value of Albumin/Globulin Ratio in Patients with Upper Tract Urothelial Carcinoma Patients Treated with Radical Nephroureterectomy

Fukushima, Hiroshi; Kobayashi, Masaki; Kawano, Keizo; Morimoto, Shinji

doi:10.21873/anticanres.12478

Cited by 12 publications

(12 citation statements)

References 11 publications

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“…Several studies have reported on the association of hypoalbuminemia with poor prognosis in patients with UC ( Table 5) (49,68,72,(78)(79)(80)(81)(82)(83)(84)(85)(86)(87)(88)(89)(90)(91). The cutoff value of albumin varies from 2 to 4 mg/L, although it is normally around 3.5 mg/L.…”

Section: Albumin and Albumin-globulin Ratiomentioning

confidence: 99%

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Role of Systemic Inflammatory Response Markers in Urothelial Carcinoma

Yuk

2020

Front. Oncol.

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Urothelial carcinoma (UC) can occur in various parts of the urinary tract and occurs in different stages and grades. The disease recurs frequently and is monitored through a series of invasive tests, such as cystoscopy or ureteroscopy, over the lifetime of an individual. Although many researchers have attempted to stratify the risks of UC, with the majority being based on cancer characteristics and host factors such as performance status, a risk classification system has yet to be fully developed. Cancer affects various parts of the body through the systemic immune response, including changes in hormones, the number and ratio of white blood cells and platelets, and C-reactive protein (CRP) or albumin levels under the influence of neuroendocrine metabolism, hematopoietic function, and protein and energy metabolism, respectively. Herein, we reviewed various systemic inflammatory response markers (SIRs) related to UC, including CRP, albumin-globulin ratio, albumin, Glasgow prognostic score (GPS), modified GPS, neutrophil-lymphocyte ratio, and platelet-lymphocyte ratio. Our aim was to summarize the role of various SIRs in the treatment of patients with UC.

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Section: Albumin and Albumin-globulin Ratiomentioning

confidence: 99%

“…However, considering the limited number of studies, the utility of this combination remains to be established. Recent studies have reported on the prognostic effect of AGR in patients with UC (85)(86)(87)(88)(89)(90)(91).…”

Section: Albumin and Albumin-globulin Ratiomentioning

confidence: 99%

Role of Systemic Inflammatory Response Markers in Urothelial Carcinoma

Yuk

2020

Front. Oncol.

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“…According to the inclusion and exclusion criteria, eight full-texts were considered eligible and included in the meta-analysis, with a total of 2,668 cases. 23 – 26 , 31 – 34 In these eight articles, three different kinds of urinary system cancers were included as follows: renal cell carcinoma (RCC, two articles), upper urinary tract urothelial carcinoma (UTUC, two articles) and bladder cancer (BC, four articles). All the included studies were prospective cohort trials.…”

Section: Resultsmentioning

confidence: 99%

Preoperative albumin-to-globulin ratio as a significant prognostic indicator in urologic cancers: a meta-analysis

Zhang

Wang

Lin

et al. 2018

CMAR

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BackgroundEmerging studies reported that preoperative albumin-to-globulin ratio (AGR) correlated with tumor progression and prognosis in several types of cancer. The aim of this study was to systematically explore the association between preoperative AGR and clinical outcomes in cancers of the urinary system.MethodsRelevant articles were searched in PubMed, Embase and Web of Science by two independent investigators from inception to June 1, 2018. Eligible studies were selected based on predetermined selection criteria. Summarized HRs or ORs and 95% CIs were calculated for prognosis and clinicopathologic features with the fixed-effects or random-effects models.ResultsEight cohort studies comprising 2,668 patients were included for analysis. The pooled results showed that a low AGR significantly correlated with poor OS (HR: 0.38, 95% CI: 0.27–0.48, P<0.001), worse cancer-specific survival (CSS) (HR: 0.36, 95% CI: 0.22–0.50, P<0.001) and inferior event-free survival (EFS) (HR: 0.36, 95% CI: 0.25–0.48, P<0.001) in urologic cancers. In addition, patients in low and high AGR groups showed significant differences in lymphovascular invasion (P<0.001), pT status (P<0.001) and pN status (P<0.001).ConclusionPreoperative AGR might be a valuable, cheap and reproducible prognostic bio-marker in urologic cancers following surgical resection.

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“…Furthermore, hypoalbuminemia was demonstrated to be associated with poor outcomes in UTUC patients. 30 Finally, as an important component of human cell membranes, cholesterol plays an essential role in maintaining the membrane structure, fluidity and membrane protein activity. 31,32 Thus, hypocholesterolemia may affect the mobility of cell surface receptors and their value in transmitting transmembrane signals.…”

Section: Discussionmentioning

confidence: 99%

<p>High Preoperative Controlling Nutritional Status Score Predicts a Poor Prognosis in Patients with Localized Upper Tract Urothelial Cancer: A Propensity Score Matching Study in a Large Chinese Center</p>

Bao¹,

Li²,

Guan³

et al. 2020

CMAR

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The aim of this study was to elucidate the prognostic value of the preoperative controlling nutritional status (CONUT) score, a new index based on the total lymphocyte count, serum albumin concentration and total cholesterol concentration, in patients with localized upper tract urothelial cancer (UTUC) after radical nephroureterectomy (RNU) using propensity score matching (PSM) analysis. Methods: We retrospectively reviewed 908 consecutive patients with localized UTUC who underwent RNU between 1999 and 2015. Patients were divided into two groups according to the optimal cutoff value of the preoperative CONUT score. Relationships between the CONUT score with clinicopathological characteristics, overall survival (OS), cancer-specific survival (CSS), and disease-free survival (DFS) were analyzed before and after 1:1 PSM. Results: A high preoperative CONUT score was significantly correlated with older age, low body mass index (BMI), poor American Statistical Association (ASA) score, advanced pathological T stage, and tumor squamous or glandular differentiation (all p<0.05). Kaplan-Meier curves showed poor OS, CSS, and DFS for patients with a high CONUT score before and after PSM (all p<0.001). Furthermore, multivariate analyses revealed that a high preoperative CONUT score was an independent risk factor for poor DFS (hazard ratio [HR] 1.418, 95% confidence interval [CI] 1.132-1.776, p=0.002) before PSM and an independent risk factor for poor DFS (HR 1.333, 95% CI 1.010-1.760, p=0.042) and OS (HR 1.459, 95% CI 1.010-2.107, p=0.044) after PSM. Conclusion: A high preoperative CONUT score is an independent prognostic factor for poor outcomes in patients with localized UTUC after RNU.

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Prognostic Value of Albumin/Globulin Ratio in Patients with Upper Tract Urothelial Carcinoma Patients Treated with Radical Nephroureterectomy

Abstract: The AGR has prognostic value in patients with UTUC undergoing RNU.

Cited by 12 publications

References 11 publications

Role of Systemic Inflammatory Response Markers in Urothelial Carcinoma

Role of Systemic Inflammatory Response Markers in Urothelial Carcinoma

Preoperative albumin-to-globulin ratio as a significant prognostic indicator in urologic cancers: a meta-analysis

<p>High Preoperative Controlling Nutritional Status Score Predicts a Poor Prognosis in Patients with Localized Upper Tract Urothelial Cancer: A Propensity Score Matching Study in a Large Chinese Center</p>

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