&lt;p&gt;High Preoperative Controlling Nutritional Status Score Predicts a Poor Prognosis in Patients with Localized Upper Tract Urothelial Cancer: A Propensity Score Matching Study in a Large Chinese Center&lt;/p&gt;

Bao, Zhengqing; Li, Yifan; Guan, Bao; Xiong, Gengyan; Zhang, Lei; Tang, Qi; Wang, Tianyu; Li, Xuesong; Fang, Dong; Zhou, Liqun

doi:10.2147/cmar.s225711

Cited by 12 publications

(18 citation statements)

References 43 publications

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“…( 5 ) As a simple, economic and efficient screening tool to detect the nutritional status of inpatients without requiring extra skills, the CONUT score has been applied in many tumors for its prognostic value. ( 6 , 7 ) Recently, it was reported that the CONUT score was independently associated with the poor prognosis in many cardiovascular disease. ( 8 , 9 ) Recently, Restrepo and colleagues proposed a view that “pneumonia as a cardiovascular disease”.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the nutritional status in patients with COVID-19

Wei

et al. 2020

J. Clin. Biochem. Nutr.

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COVID-19 has been a global health threat. We aimed to investigate the nutrition status of COVID-19 patients and evaluate the prognostic value of the controlling nutritional status (CONUT) score in these patients. 348 severe patients with COVID-19 were collected. Based on the CONUT score, 161 (46.3%) patients had mild malnutrition while 139 (39.9%) patients had moderate-severe malnutrition. Compared to the patients in normal and mild groups, the patients in moderate-severe group were older, more male, had higher counts of white blood cell and neutrophil as well as higher serum levels of C-reactive protein. Nearly half of patients (44.6%) in moderate-severe group developed acute cardiac injury, while 6.3% and 15.5% patients in normal and mild group, respectively. Patients with moderate-severe malnutrition exhibited a higher mortality than those patients with normal and mild malnutrition. Multivariate regression analysis showed the CONUT score was the independent predictor of death in patients with COVID-19 (odds ratio: 1.410; 95%CI: 1.089–1.825; p = 0.009). Malnutrition is significantly associated with poor outcome of COVID-19, while the prognosis of patients with normal nutrition status is relative favorable. The CONUT score independently predicts the prognosis of COVID-19 patients, which can help physicians to clarify patients with poor prognosis.

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Section: Introductionmentioning

confidence: 99%

Evaluation of the nutritional status in patients with COVID-19

Wei

et al. 2020

J. Clin. Biochem. Nutr.

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“…Excluded from 7 reviews, 7 letters, and comments, 3 studies were unable to extract data entirely, and 2 studies with low literature quality scores. 7 retrospective studies and 1 propensity matching scoring study with 2232 patients were included in this meta-analysis at last (Figure 1) (22)(23)(24)(25)(26)(27)(28)(29).…”

Section: Description Of Studiesmentioning

confidence: 99%

“…8 studies reported the HR of the low CONUT group and the high CONUT group on OS, and a total of 2232 patients were enrolled (22)(23)(24)(25)(26)(27)(28)(29). After the heterogeneity test, the heterogeneity among the studies was within the acceptable range (I 2 = 45.6%, P=0.075), and the fixed-effects model was used to pool HR.…”

Section: Survival Outcomesmentioning

confidence: 99%

Controlling Nutritional Status Score Before Receiving Treatment as a Prognostic Indicator for Patients With Urothelial Cancer: An Exploration Evaluation Methods

Peng

Meng

et al. 2021

Front. Oncol.

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IntroductionThis meta-analysis aims to assess whether the Controlling nutritional status (CONUT) score before treatment can be an independent predictor of the prognosis of patients with urothelial cancer (UC).MethodsThe system searches Web of Science, PubMed, MEDLINE, China National Knowledge Infrastructure (CNKI), and Cochrane Library, and the search time is up to April 2021. Use STATA 16.0 and Engauge Digitizer 4.1 software for data processing and statistical analysis.ResultsA total of 8 studies were included in this meta-analysis. The meta-analysis results show that compared with the low CONUT group, the high CONUT group has worse over survival (OS) [HR=1.58, 95%CI (1.34, 1.86), P=0.001], cancer-specific survival (CSS) [HR=2.03, 95%CI (1.25-3.29), P=0.04] and recurrence-free survival (RFS) [HR=1.97, 95%CI (1.15, 3.40), P=0.014]; for progression-free survival (PFS), or disease-free survival (DFS), the difference between the two groups was not statistically significant [HR=2.30, 95%CI (0.72, 7.32), P=0.158]. According to different carcinoma types, cut-off value, and region, subgroup analysis of OS was performed, and similar results were obtained.ConclusionsBased on current evidence, this meta-analysis proves that the CONUT score of UC patients before treatment is an independent prognostic predictor. It performs well on OS, CSS, and RFS, but the conclusions on DFS/PFS need to be treated with caution.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42021251890, identifier CRD42021251890.

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“…We initially identified 672 studies from the three databases mentioned above. Ten studies were ultimately included in this meta-analysis based on our inclusion and exclusion criteria (14)(15)(16)(17)(18)(19)(20)(21)(22)(23). A total of 12,865 patients had UTUC, and 2045 (15.9%) had diabetes.…”

Section: Literature Screening and Quality Assessmentmentioning

confidence: 99%

The Impact of Diabetes on the Prognosis of Upper Tract Urothelial Carcinoma After Radical Nephroureterectomy: A Systematic Review and Meta-Analysis

Gao

Zhou

et al. 2021

Front. Oncol.

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BackgroundStudies have reported that diabetes is related to the prognosis of upper tract urothelial carcinoma (UTUC) after radical nephroureterectomy (RNU), but this conclusion is still controversial. Here, we performed a meta-analysis to comprehensively explore the association between diabetes and UTUC prognosis.MethodsIn November 2020, we searched PubMed, Web of science and the Cochrane Library to find relevant studies that evaluated the effect of diabetes on the prognosis of UTUC. The Newcastle Ottawa Scale was used to assess the quality of the literature. Review Manager 5.3 was used to pool cancer-specific survival (CSS), overall survival (OS), recurrence-free survival (RFS) and intravesical recurrence (IVR).ResultsA total of 10 studies with 11,303 patients were included in this meta-analysis. Our pooled results showed that diabetes did not affect the survival outcome of UTUC, including CSS (HR: 1.33, 95% CI: 0.89-1.98; P = 0.16), OS (HR: 1.18, 95% CI: 0.77-1.80; P = 0.45) and RFS (HR: 1.37, 95% CI: 0.91-2.05; P = 0.13). However, diabetes increased the risk of IVR of UTUC patients (HR: 1.26, 95% CI: 1.11-1.43; P = 0.0004).ConclusionAlthough diabetes has no significant impact on the survival outcomes of UTUC after RNU, it increases the risk of IVR. Therefore, special attention should be paid to monitoring the IVR for UTUC patients with diabetes and the necessity of appropriate intravesical adjuvant treatment when needed.

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<p>High Preoperative Controlling Nutritional Status Score Predicts a Poor Prognosis in Patients with Localized Upper Tract Urothelial Cancer: A Propensity Score Matching Study in a Large Chinese Center</p>

Cited by 12 publications

References 43 publications

Evaluation of the nutritional status in patients with COVID-19

Evaluation of the nutritional status in patients with COVID-19

Controlling Nutritional Status Score Before Receiving Treatment as a Prognostic Indicator for Patients With Urothelial Cancer: An Exploration Evaluation Methods

The Impact of Diabetes on the Prognosis of Upper Tract Urothelial Carcinoma After Radical Nephroureterectomy: A Systematic Review and Meta-Analysis

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