2019
DOI: 10.1177/1758835919830831
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Prognostic value of ALDH1 and Nestin in advanced cancer: a systematic meta-analysis with trial sequential analysis

Abstract: Background: Novel prognostic markers and therapeutic targets for advanced cancer are urgently needed. This report with trial sequential analysis (TSA) was first conducted to provide robust estimates of the correlation between aldehyde dehydrogenase 1 (ALDH1) and Nestin and clinical outcomes of advanced cancer patients. Methods: Hazard ratios (HRs) with 95% confidence intervals (CIs) were summarized for overall survival (OS), disease-free survival (DFS), progression-free… Show more

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Cited by 21 publications
(20 citation statements)
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References 79 publications
(116 reference statements)
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“…OS was used as the most common gold standard end point in clinical studies. Because OS is easily measured, the definition is precise, and measurement is reliable and unbiased [19,20]. In this study, an event such as progression, recurrence, second malignant neoplasm, or death was defined as EFS.…”
Section: Discussionmentioning
confidence: 99%
“…OS was used as the most common gold standard end point in clinical studies. Because OS is easily measured, the definition is precise, and measurement is reliable and unbiased [19,20]. In this study, an event such as progression, recurrence, second malignant neoplasm, or death was defined as EFS.…”
Section: Discussionmentioning
confidence: 99%
“…The statistical heterogeneity between studies was estimated using the Cochran’s Q statistic [29]. The random-effects model (DerSimonian and Laird method) was used to improve the reliability of the data [30]. When significant heterogeneity was present ( P < 0.1), a sensitivity analysis was performed to evaluate the influence and stability of one study on the results by deleting a single study [31].…”
Section: Methodsmentioning
confidence: 99%
“…Cancer stem cells (CSCs) are a special subpopulation of tumor cells and have the ability and characteristics of self-renewal and multilineage differentiation and proliferation potential, which are related to tumor progression, metastasis, recurrence, prognosis, and drug resistance [6][7][8]. Many CSC-related markers have been identified and reported to be associated with poor prognosis and resistance to therapy in cancer [9,10]. Sex-determining region Y-box 2 (SOX2), a high mobility group (HMG) DNA-binding domain, is mapped to human chromosome 3q26.3-q27 and belongs to a key transcription factor [11].…”
Section: Introductionmentioning
confidence: 99%