Prognostic value of carcinoembryonic antigen on outcome in patients with coronavirus disease 2019

Yu, Jing; Yang, Zhifeng; Zhou, Xia; Wu, Dongde; Chen, Jian; Zhang, Ling; Tong, Luqing

doi:10.1016/j.jinf.2020.06.018

Cited by 9 publications

(23 citation statements)

References 7 publications

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“…The levels of certain inflammatory biomarkers, such as C-reactive protein (CRP), lymphocyte (L) percentage, neutrophils percentage (Neu%), interleukin-6 (IL-6), procalcitonin (PCT), ferritin (Fer), D-dimer (D2), and the white blood cell (WBC) count, have been used to assess disease progression ( 3 – 5 ). Our previous study noted that the carcinoembryonic antigen (CEA) level is an independent prognostic marker for COVID-19 ( 6 ). In the present study, we aimed to explore the value of all the above markers to diagnose and predict the prognosis of COVID-19.…”

Section: Introductionmentioning

confidence: 99%

Prognostic Value of a Clinical Biochemistry-Based Nomogram for Coronavirus Disease 2019

Chen

et al. 2021

Front. Med.

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Background: This study aimed to explore the predictive value of a clinical biochemistry-based nomogram in COVID-19.Methods: The plasma or serum concentrations/levels of carcinoembryonic antigen (CEA) and other biomarkers, e.g., C-reactive protein (CRP), white blood cell (WBC), interleukin-6 (IL-6), ferritin (Fer), procalcitonin (PCT), lymphocyte percentage (L%), D-dimer (D2), and neutrophils percentage (Neu%), were assessed in 314 hospitalized patients with confirmed COVID-19. The area under the curve was used to estimate the diagnostic and prognostic value for COVID-19. Cox and logistic regression analyses were used to estimate the independent prognostic risk factors for the survival of patients with COVID-19.Results: Receiver operating characteristic (ROC) curves were used to determine the area under the curve (AUC) values for CEA, IL-6, CRP, PCT, Fer, D-dimer levels and L%, Neu%, and WBC to assess disease classification. The critical values for these markers to predict severe disease type were then determined. The hazard ratio of prognosis for risk of COVID-19 identified CEA, WBC, CRP, PCT, Fer, D-dimer, Neu%, and L% as independent prognostic factors. For the nomogram of overall survival (OS), the C-index was 0.84, demonstrating a good discriminative performance.Conclusions: An OS nomogram for the clinical diagnosis and treatment of COVID-19 was constructed using biomarkers. These data will be useful for the diagnosis, management, and therapy of COVID-19.

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Section: Introductionmentioning

confidence: 99%

Prognostic Value of a Clinical Biochemistry-Based Nomogram for Coronavirus Disease 2019

Chen

et al. 2021

Front. Med.

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“…The prevalence of COVID-19 began in December 2019, then spread worldwide, and now is an ongoing pandemic caused by SARS -CoV-2. [3][4][5] All over the world scientists are trying to understand viral tropism better and the main problem is to develop therapeutic approaches for preventing virus infection and spreading. As this situation has become an urgent public health challenge, it aroused our curiosity to investigate a set of some significant tumor biomarkers in patients with COVID-19.…”

Section: Discussionmentioning

confidence: 99%

“…The prevalence of COVID‐19 began in December 2019, then spread worldwide, and now is an ongoing pandemic caused by SARS‐CoV‐2 3–5 …”

Section: Discussionmentioning

confidence: 99%

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Effect of the coronavirus pandemic on tumor markers

Purut

Giray

Gürbüz

2021

Journal of Medical Virology

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The new type of coronavirus could cause severe acute respiratory syndrome and injuries in other systems as well. Multiple organ damage can occur rapidly in patients infected with coronavirus disease 2019 (COVID‐19). Previous studies have shown that many laboratory biomarkers were not within the normal ranges in COVID‐19 patients. We aimed to summarize laboratory parameters and the tumor markers in COVID‐19 patients. This is a retrospective cohort study conducted on 53 women between the ages of 19–85 years infected with COVID‐19 at a training and research hospital between May 2020 and August 2020. Of the 53 women, 16 (30.2%) had leukopenia. The mean C‐reactive protein level was 18.42 ± 59.33 mg/L. The mean procalcitonin level was 0.1 ± 0.21 µg/L. The liver function tests were within normal limits. The mean creatinine level was 0.58 ± 0.37 mg/dl. Elevated levels of α‐fetoprotein (AFP) in 1 patient, elevated levels of carcinoembryonic antigen (CEA) in 2 patients, elevated levels of cancer antigen 125 (CA125) in 4 patients, elevated levels of CA19‐9 in 2 patients, and elevated levels of CA15‐3 in 2 patients were detected. One of 4 patients who were taken to the intensive care unit had elevated levels of AFP. In addition, 2 of 4 patients who were taken to the intensive care unit had elevated levels of CA125 and CA15‐3. Except for AFP, levels of all tumor markers of the patient who died were high. We found that COVID‐19 had no effect on tumor markers (CA125, CA19‐9, CA15‐3, AFP, and CEA).

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“…According to the ndings of our previous study, carcinoembryonic antigen (CEA) is a prognostic marker of COVID-19 [8]; therefore, CEA was included in the present nomogram analysis. Based on the multivariate analysis conducted in the present study, a prognostic nomogram for OS of COVID-19 patients with bacterial co-infection was created (Fig.…”

Section: The Prognostic Nomogram Of Covid-19 Patients With Bacterial mentioning

confidence: 99%

Bacteriological Characteristics of COVID-19 Patients Nosocomially Co-infected at a Designated Hospital: A Retrospective Study

Nie¹,

Zhou²,

Wu³

et al. 2020

Preprint

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Background: Bacterial co-infection in patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a critical factor that increases the complexity and treatment of coronavirus disease 2019 (COVID-19). Methods: We collected the clinical laboratory data of 1799 patients with confirmed COVID-19 who were admitted to Jinyintan Hospital in Wuhan, China, between January 1 to April 26, 2020. The bacterial co-infection along with disease progression was analyzed. Other inflammatory markers, including C-reactive protein (CRP), white blood cells (WBC), lymphocytes (L), neutrocytes (N), interleukin-6 (IL-6), and procalcitonin (PCT), were assessed to estimate the progression of COVID-19. Results: We found that 191 of the 1799 (10.62%) patients had bacterial co-infection. The most prevalent causative agents for bacterial co-infection were Klebsiella pneumoniae (91 cases, 5.06%) and Acinetobacter baumannii (66 cases, 3.67%). The most patients with bacterial co-infection showed extensive drug-resistance. The outcomes of patients with bacterial co-infection were worse than those of patients without bacterial co-infection.Conclusions: Secondary bacterial pneumonia during virus infection is a major risk factor for high mortality resulting from severe pneumonia caused by COVID-19.

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Prognostic value of carcinoembryonic antigen on outcome in patients with coronavirus disease 2019

Cited by 9 publications

References 7 publications

Prognostic Value of a Clinical Biochemistry-Based Nomogram for Coronavirus Disease 2019

Prognostic Value of a Clinical Biochemistry-Based Nomogram for Coronavirus Disease 2019

Effect of the coronavirus pandemic on tumor markers

Bacteriological Characteristics of COVID-19 Patients Nosocomially Co-infected at a Designated Hospital: A Retrospective Study

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