2022
DOI: 10.1186/s12885-022-09628-8
|View full text |Cite
|
Sign up to set email alerts
|

Prognostic value of CD4+ T lymphopenia in non-small cell lung Cancer

Abstract: Background There is a paucity of data regarding the prognostic influence of peripheral blood CD4+ T lymphopenia in non-small cell lung cancer (NSCLC). Therefore, we investigated the prognostic value of T lymphopenia in NSCLC. Materials Treatment-naive patients with a pathological diagnosis of NSCLC, at clinical stage I to IV were included in the prospective TELOCAP1 study. Lymphocytes count was evaluated in peripheral blood by flow cytometry. CD4+ … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
4
1

Citation Types

1
8
0

Year Published

2022
2022
2024
2024

Publication Types

Select...
8

Relationship

0
8

Authors

Journals

citations
Cited by 18 publications
(9 citation statements)
references
References 36 publications
1
8
0
Order By: Relevance
“…Due to the relevance of both CD4+ and CD8 + T cell quantification in ICI response [ 37 , 38 ], we assessed and depicted the impact of the CD4/CD8 ratio in the peripheral blood in the outcome of our patients. Patients with a high CD4/CD8 ratio, meaning a physiological higher abundance of CD4+ related to CD8 + T cells in the periphery, at baseline and during therapy, responded better to therapy and lived longer.…”
Section: Discussionmentioning
confidence: 99%
“…Due to the relevance of both CD4+ and CD8 + T cell quantification in ICI response [ 37 , 38 ], we assessed and depicted the impact of the CD4/CD8 ratio in the peripheral blood in the outcome of our patients. Patients with a high CD4/CD8 ratio, meaning a physiological higher abundance of CD4+ related to CD8 + T cells in the periphery, at baseline and during therapy, responded better to therapy and lived longer.…”
Section: Discussionmentioning
confidence: 99%
“…Lymphocytes are the main antitumor cells and play an important role in cell-mediated immune response by recognizing and killing cancer cells[ 27 ]. Lymphopenia is related to the adverse reactions and prognosis of a variety of malignant tumors, including GC[ 28 , 29 ]. However, patients with malignant tumor with increased neutrophil infiltration often have poor clinical outcomes.…”
Section: Discussionmentioning
confidence: 99%
“…25 Patients with non-small cell lung cancer lacking CD4+ T cells have a worse prognosis, whereas enhancing CD4+ T cells in non-small cell lung cancer has a significant improvement in patient survival. [32][33][34] In addition, different CD4+ T cell subtypes have different roles in lung cancer. Treg cells are a class of immunomodulatory cells that play a major role in immunosuppression, and their large infiltration in the immune microenvironment of lung cancer can diminish the anticancer effect of patients, which is related to stage, treatment, and prognosis.…”
Section: Discussionmentioning
confidence: 99%
“…CD4+ T cells can also promote immune checkpoint blockade by interacting with dendritic cells 25 . Patients with non‐small cell lung cancer lacking CD4+ T cells have a worse prognosis, whereas enhancing CD4+ T cells in non‐small cell lung cancer has a significant improvement in patient survival 32–34 . In addition, different CD4+ T cell subtypes have different roles in lung cancer.…”
Section: Discussionmentioning
confidence: 99%