Prognostic Value of Circadian Rhythm of Brain Temperature in Traumatic Brain Injury

Kuo, Lu-Ting; Lu, Hsueh-Yi; Huang, Abel Po‐Hao

doi:10.3390/jpm11070620

Cited by 5 publications

(4 citation statements)

References 47 publications

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“…The peak cBT in sham-operated rats was at 00:16 AM, which is comparable to the findings of a previous study [ 74 ]. In a study comprising 108 patients with moderate-to-severe TBI, 40.7% presented disrupted brain temperature rhythm; however, some patients with normal brain temperature rhythm still exhibited phase shifts [ 13 ]. Only a few studies have investigated the rhythms and acrophases of body or brain temperature in patients after brain injuries.…”

Section: Discussionmentioning

confidence: 99%

“…Circadian gene expression within the SCN governs the rhythms of various cellular metabolic processes, neuronal firing, and neuropeptide secretion, which ultimately manifest in physiological and behavioral rhythms [ 9 , 11 , 12 ]. A previous study demonstrated that 40.7% of patients with moderate-to-severe traumatic brain injury (TBI) exhibit disturbed circadian rhythms of brain temperature with a diminished amplitude in the first 72 h following operation [ 13 ]. However, the effects of TBI on the regulation of circadian rhythm-related gene expression in peripheral tissues have not yet been investigated in humans or animal models.…”

Section: Introductionmentioning

confidence: 99%

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Traumatic brain injury-induced disruption of the circadian clock

Kuo,

Lu,

Chen

2024

J Mol Med

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Disturbances in the circadian rhythm have been reported in patients following traumatic brain injury (TBI). However, the rhythmic expression of circadian genes in peripheral blood leukocytes (PBL) following TBI has not yet been studied. The messenger ribonucleic acid (mRNA) expression of period 1 (Per1), Per2, Per3, cryptochrome 1 (Cry1), Cry2, brain and muscle aryl hydrocarbon receptor nuclear translocator-like 1 (Bmal1), and circadian locomotor output cycles kaput (Clock) was quantified in PBLs from sham-operated rats and rats with acute subdural hematoma (ASDH) over a 48-h period. The rectal temperature of the animals was measured every 4 h over 2 days. The mesor, rhythm, amplitude, and acrophase were estimated using cosinor analysis. Cosinor analysis revealed that Per2, Cry1, and Bmal1 mRNAs were rhythmically expressed in the PBLs of sham-operated rats. In contrast, fluctuations in rhythmic expression were not observed following ASDH. The rectal temperature of sham-operated rats also exhibited rhythmicity. ASDH rats had a disrupted rectal temperature rhythm, a diminished amplitude, and an acrophase shift. TBI with ASDH results in dysregulated expression of some circadian genes and changes in body temperature rhythm. Further research is required to understand the pathophysiology of altered circadian networks following TBI. Key messages First to investigate the mRNA expression of circadian genes in PBLs of ASDH rats. ASDH rats had disrupted rhythmicity of Per2, Cry1, and Bmal1 mRNA expression. Cosinor analysis showed that ASDH rats had a disrupted rectal temperature rhythm.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Traumatic brain injury-induced disruption of the circadian clock

Kuo,

Lu,

Chen

2024

J Mol Med

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“…The incidence of systemic injury, especially craniocerebral injury, is rising yearly, leading to increasing rates of disability and fatality and bringing a massive burden to individuals, families, and society [31] . Accurate evaluation of traumatic brain injury is of great significance for diagnosis and treatment, and prognosis evaluation [32] . In this study, the predictive ability of serum miR-185-5p level on clinical damage and prognosis of TBI patients was evaluated, and it was found that serum miR-185-5p level was closely related to trauma severity of TBI patients.…”

Section: Discussionmentioning

confidence: 99%

Study on serum miR-185-5p in assessing the injury severity and prognosis of patients with traumatic brain injury

Wu¹,

Chen²,

Xiang³

et al. 2023

J Med Biochemistry

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Objective This study aims to explore whether serum miR-185-5p levels are related to the degree of injury and prognosis of traumatic brain injury patients. Methods Quantify the serum miR-185-5p level of 120 TBI patients. The Glasgow Coma Scale (GCS) was used to grade the damage, and the Glasgow Outcome Scale (GOS) was used to evaluate the prognosis 3 months after the trauma. Pearson correlation analysis was performed to determine the relationship between serum miR-185-5p level and injury degree and prognosis, and the value of serum miR-185-5p level on injury degree and prognosis was evaluated by receiver operating characteristic (ROC) curve. Results The level of serum miR-185-5p in patients with moderate or severe TBI was significantly higher than that in the mild group, and the level of miR-185-5p was closely related to the GCS score and GOS score. Serum miR-185-5p levels higher than 0.36 can distinguish TBI patients with mild and moderate injury with a sensitivity of 72.97% and a specificity of 97.62%; higher than 0.43, a sensitivity of 46.34% and a specificity of 91.89% can be distinguished significantly TBI patients are moderately and severely injured; higher than 0.36, with a sensitivity of 96.30% and a specificity of 60.24%, significantly distinguish the poor prognosis of TBI patients. Serum miR-185-5p level becomes an independent predictor of TBI patients with poor prognosis for 3 months. Under the ROC curve, the serum miR-185-5p level showed an effective ability to discriminate adverse outcomes at 3 months. Conclusions Serum miR-185-5p level is significantly correlated with the degree of injury and poor prognosis of TBI patients at 3 months, indicating that serum miR-185-5p level may be a biomarker that provides supplementary prognostic information to identify the risk of poor prognosis in TBI patients.

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“…24 Brain temperature also oscillates, and amplitude of these rhythms may predict survival after traumatic brain injury. 25,26 Here, we review and discuss evidence that these basic physiological rhythms may alter brain homeostasis.…”

Section: Basics Of Circadian Rhythmsmentioning

confidence: 99%

Circadian Mechanisms in Brain Fluid Biology

Vizcarra,

Fame,

Hablitz

2024

Circulation Research

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The brain is a complex organ, fundamentally changing across the day to perform basic functions like sleep, thought, and regulating whole-body physiology. This requires a complex symphony of nutrients, hormones, ions, neurotransmitters and more to be properly distributed across the brain to maintain homeostasis throughout 24 hours. These solutes are distributed both by the blood and by cerebrospinal fluid. Cerebrospinal fluid contents are distinct from the general circulation because of regulation at brain barriers including the choroid plexus, glymphatic system, and blood-brain barrier. In this review, we discuss the overlapping circadian (≈24-hour) rhythms in brain fluid biology and at the brain barriers. Our goal is for the reader to gain both a fundamental understanding of brain barriers alongside an understanding of the interactions between these fluids and the circadian timing system. Ultimately, this review will provide new insight into how alterations in these finely tuned clocks may lead to pathology.

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Prognostic Value of Circadian Rhythm of Brain Temperature in Traumatic Brain Injury

Cited by 5 publications

References 47 publications

Traumatic brain injury-induced disruption of the circadian clock

Traumatic brain injury-induced disruption of the circadian clock

Study on serum miR-185-5p in assessing the injury severity and prognosis of patients with traumatic brain injury

Circadian Mechanisms in Brain Fluid Biology

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