Prognostic value of combined preoperative fibrinogen-albumin ratio and platelet-lymphocyte ratio score in patients with breast cancer: A prognostic nomogram study

Zheng, Yufen; Wu, Chunlong; Yan, Haixi; Chen, Shiyong

doi:10.1016/j.cca.2020.03.011

Cited by 30 publications

(30 citation statements)

References 21 publications

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“…Many studies have reported that plasma fibrinogen levels are positively correlated with many inflammation scores, such as the neutrophil/lymphocyte ratio, platelet/lymphocyte ratio and lymphocyte/monocyte ratio. 23,31 Fibrinogen can also induce the synthesis of interleukin 6 to promote tumor progression. 32 Albumin is the most abundant circulating protein in the plasma and is not only a nutritional indicator but can also be involved in the inflammatory response.…”

Section: Discussionmentioning

confidence: 99%

Fibrinogen/Albumin Ratio as a Promising Marker for Predicting Survival in Pancreatic Neuroendocrine Neoplasms

Deng

Fan

Xia

et al. 2021

CMAR

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Section: Discussionmentioning

confidence: 99%

Fibrinogen/Albumin Ratio as a Promising Marker for Predicting Survival in Pancreatic Neuroendocrine Neoplasms

Deng

Fan

Xia

et al. 2021

CMAR

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“…Although the fibrinogen / albumin ratio (FAR) has been widely reported to predict tumor prognosis recently (16,18,19) .But as far as we know, this is the first article to report FAR as an independent risk factor to predict the prognosis of patients with urothelial carcinoma after radical cystectomy.…”

Section: Discussionmentioning

confidence: 90%

“…Inflammation is considered to be an important participant in the occurrence, development and metastasis of tumors. Many inflammation related indicators, including the ratio of neutrophil count to lymphocyte count (NLR) (20)(21)(22)(23) 、the ratio of neutrophil count/( leukocyte count -neutrophil count) (dNLR) (20,22,24) and the ratio of platelet count to lymphocyte count (PLR) (19)(20)(21)(22)(23)(24) have been reported to be used to predict the prognosis of human tumors. However, in our study, these indicators can't be used as independent risk factors to predict the prognosis of patients with urothelial carcinoma after radical cystectomy.…”

Section: Discussionmentioning

confidence: 99%

“…Most tumor patients have hypercoagulable state (4) ,some studies have shown that serum high fibrinogen is related to poor prognosis of tumor patients (5,6) ,and fibrinogen has also been found to play a role in many parts of tumor development (7)(8)(9)(10) .Albumin is considered to be an objective indicator of nutritional status (11,12) ,low serum albumin level often indicates poor prognosis of tumor patients (13)(14)(15) .Previously, a retrospective study at Sun Yat sen University found that the preoperative fibrinogen / albumin ratio (FAR) can be used as a predictor of postoperative prognosis in patients with soft tissue sarcoma (16) .After that, many studies were exploring the feasibility of FAR in predicting prognosis of different pathological types of tumors (16)(17)(18)(19) .…”

Section: Introductionmentioning

confidence: 99%

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Preoperative fibrinogen / albumin ratio (FAR) Can be used to predict the prognosis of urothelial carcinoma patients after radical cystectomy

Liang

Song

Liu

et al. 2021

Preprint

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Purpose: To explore the feasibility of preoperative fibrinogen / albumin ratio (FAR) as a predictor of the total and elderly patients with urothelial carcinoma after radical cystectomy. Methods: A cohort of 275 patients who underwent radical cystectomy for bladder tumor at Peking University First Hospital from 2012 to 2016 was analyzed retrospectively. The optimal cutoff value of FAR group was determined according to the survival dependent receiver operating characteristic curve (survival-ROC). Kaplan-Meier curve was used to analysis the overall survival (OS), and Cox proportional hazards model was used for univariate and multivariate analysis. Result: The AUC value of FAR in the survival-ROC curve is higher than other clinical indexes, and the cutoff value of FAR determined by survival-ROC is 0.0707. We found that the median survival time (27.63 months vs 32.11 months, P < 0.01) and 5-year survival rate (77.7% vs 92.7%, P < 0.01) in the high FAR group were significantly lower than those in the low FAR group. In the multivariate survival analysis, the FAR and AJCC stages were independent risk factors for long-term prognosis. In subgroup analysis, the long-term survival of patients in AJCC I+II subgroup, G1 + G2 subgroup, G3 subgroup, lymph nodes negative subgroup and old patient subgroup were all related to FAR, while the 5-years survival of patients in AJCCIII+IV subgroup, lymph nodes positive subgroup and young patient subgroup was not related to FAR. Conclusion: The value of FAR can be used as an independent risk factor to predict the prognosis of patients with bladder cancer after radical cystectomy, especially for patients with elder age, lymph nodes negative, or AJCC I + II stage.

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“…Huang et al reported that the systemic inflammation score (SIS) based on ALB and LMR could predict the survival of breast cancer patients [ 32 ]. Zheng et al found that fibrinogen-albumin ratio and platelet-lymphocyte ratio score was a prognostic factor of breast cancer [ 33 ], and NLR has been shown to predict the efficacy of neoadjuvant chemotherapy in breast cancer [ 34 , 35 ]. However, these indicators all partially analyzed the influence of systemic inflammation on breast cancer.…”

Section: Discussionmentioning

confidence: 99%

A Systemic Inflammation Response Score for Prognostic Prediction of Breast Cancer Patients Undergoing Surgery

Zhang

Ping

et al. 2021

JPM

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Background: Systemic inflammatory response is related to the occurrence, progression, and prognosis of cancers. In this research, a novel systemic inflammation response score (SIRS) was calculated, and its prognostic value for postoperative stage I-III breast cancer (BC) patients was analyzed. Methods: 1583 BC patients were included in this research. Patients were randomly divided into a training cohort (n = 1187) and validation cohort (n = 396). SIRS was established in the training cohort based on independent prognostic hematological indicator, its relationship between prognosis and clinical features was analyzed. Then, a nomogram consisted of SIRS and clinical features was established, its performance was examined by calibration plots and receiver operating characteristic curve analysis. Results: The SIRS was an independent prognostic indicator for BC patients, and a high-SIRS was related to multifocality, advanced N stage, and worse prognosis. Incorporating SIRS into a nomogram could accurately predict the prognosis of BC patients, the results of receiver operating characteristic (ROC) curve analysis showed that the area under the curve (AUC) of nomogram was up to 0.806 in training cohort and 0.905 in the validation cohort. Conclusion: SIRS was associated with the prognosis of patients with breast cancer. Nomogram based on SIRS can accurately predict the prognosis of breast cancer patients.

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Prognostic value of combined preoperative fibrinogen-albumin ratio and platelet-lymphocyte ratio score in patients with breast cancer: A prognostic nomogram study

Cited by 30 publications

References 21 publications

Fibrinogen/Albumin Ratio as a Promising Marker for Predicting Survival in Pancreatic Neuroendocrine Neoplasms

Fibrinogen/Albumin Ratio as a Promising Marker for Predicting Survival in Pancreatic Neuroendocrine Neoplasms

Preoperative fibrinogen / albumin ratio (FAR) Can be used to predict the prognosis of urothelial carcinoma patients after radical cystectomy

A Systemic Inflammation Response Score for Prognostic Prediction of Breast Cancer Patients Undergoing Surgery

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