Prognostic value of FUS immunoexpression for Gleason patterns and prostatic adenocarcinoma progression

Hirth, Carlos Gustavo; Vasconcelos, Gislane Rocha; Lima, Marcos Venício Alves; Cunha, Maria do Perpétuo Socorro Saldanha da; Frederico, Ingrid K S; Dornelas, Conceição Aparecida

doi:10.1016/j.anndiagpath.2021.151729

Cited by 2 publications

(3 citation statements)

References 29 publications

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“…FUS is a member of the FET/TET protein family and is closely related to the pathogenesis of PRAD. Gleason pattern analysis also found that the frequency of FUS positive in nontumor tissues was lower than in PRAD tumor tissues [ 1 ]. Studies have found that low FUS expression in prostate cancer cell lines VCaP and LNCaP can phenomenally inhibit the expression of androgen AR and its downstream targets IGF1R and EGFR, thus inhibiting PRAD proliferation [ 19 ].…”

Section: Discussionmentioning

confidence: 99%

“…Prostate adenocarcinoma (PRAD) is the most common tumor in men, with high morbidity and mortality [ 1 , 2 ]. Surgery and chemotherapy are the main means of PRAD treatment, but the recurrence rate is high, and the prognosis is poor [ 3 , 4 ].…”

Section: Introductionmentioning

confidence: 99%

“…The fused sarcoma protein (FUS) is involved in the presplicesome of mRNA and gene transcription, etc. [ 1 , 18 ]. Meanwhile, it was an important marker of PRAD occurrence and death [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

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mRNA-Modified FUS/NRF2 Signalling Inhibits Ferroptosis and Promotes Prostate Cancer Growth

Wang¹,

Yu²,

Wang³

et al. 2022

Computational and Mathematical Methods in Medicine

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Objective. Regarding the imperfect mechanism of occurrence and development of prostate adenocarcinoma (PRAD), this study investigated mRNA-modified FUS/NRF2 signalling to inhibit ferroptosis and promote prostate adenocarcinoma growth. Methods. Bioinformatics analysis was used to obtain the expression of FUS and its mRNA modification in PRAD. The expression of FUS in prostate cells (CRPC) and the level of m6A methylation modification, ferroptosis (P53 and GPX4), apoptosis (Caspase3), ferroptosis (P53 and GPX4), and apoptosis (Caspase3) in CRPC after ferroptosis inducer Erastin, ferroptosis inhibitor, and FUS knockdown were detected. Autophagy (LC3B), oxidative stress (GSH and ROS), and expression of NRF2/HO-1 pathway are indicators. Results. FUS was highly expressed in PRAD and phenomenally reduced the survival rate of patients. After knocking down FUS, the level of m6A methylation was significantly reduced, and the expressions of ferroptosis markers P53 and GPX4 were phenomenally reduced, while the levels of apoptosis and autophagy markers Caspase3 and LC3B remained unchanged. Upregulated and NRF2/HO-1 pathway indicators were upregulated. It shows that m6A methylation modification is reduced when FUS is the low expression, inhibits the expression of P53 and GPX4, downregulates GSH, upregulates ROS, activates the NRF2/HO-1 pathway, and promotes ferroptosis to inhibit the occurrence of RPAD. Conclusions. The increase of m6A methylation modification can increase the expression of FUS, thereby promoting the expression of P53 and GPX4, upregulating GSH, downregulating ROS, inhibiting the NRF2/HO-1 pathway, inhibiting ferroptosis, and promoting the growth of PRAD.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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mRNA-Modified FUS/NRF2 Signalling Inhibits Ferroptosis and Promotes Prostate Cancer Growth

Wang¹,

Yu²,

Wang³

et al. 2022

Computational and Mathematical Methods in Medicine

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Air data computer simulation and design credibility assessment considering ADC calculation model

Zhang¹,

Zhang²

2023

Applied Mathematics and Nonlinear Sciences

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Air data computer simulation system is a platform for studying aircraft air data system. It can also replace real air data computer and can be used in the experiment of ground integrated avionics system, which greatly reduces the cost and risk of the experiment. However, when the simulation system replaces the real system, whether its reliability, integrity and other indicators can meet the requirements becomes the key to the problem. Based on computer simulation theory and simulation credibility evaluation theory, this paper designs and implements two types of atmospheric data computer simulation systems and evaluates the credibility of the simulation systems. The basic theory of computer simulation and the general process of simulation are expounded, the evaluation theory of simulation credibility is introduced, and the evaluation calculation method of simulation credibility is given. The results show that the highest reliability of the reliability evaluation using the method in this paper reaches 90%, the highest error rate is 0.06%, and the average accuracy, efficiency and complexity of the hundred experiments are 97.31% and 97.00% and 0.154%. The highest reliability of the subjective comprehensive evaluation algorithm for reliability evaluation is 65%, the highest error rate is 0.27%, and the average accuracy, efficiency and complexity of the hundred experiments are 70.59% and 69.74%, and 0.502%. Therefore, the method in this paper not only has high reliability, low error rate, but also has strong comprehensive effectiveness.

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Prognostic value of FUS immunoexpression for Gleason patterns and prostatic adenocarcinoma progression

Cited by 2 publications

References 29 publications

mRNA-Modified FUS/NRF2 Signalling Inhibits Ferroptosis and Promotes Prostate Cancer Growth

mRNA-Modified FUS/NRF2 Signalling Inhibits Ferroptosis and Promotes Prostate Cancer Growth

Air data computer simulation and design credibility assessment considering ADC calculation model

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