Prognostic value of glasgow prognostic score in patients with non-small cell lung cancers undergoing pn2 pneumonectomy

Abstract

Background: The aim of this study was to assess the relationship between Glasgow Prognosis Score (GPS) and survival in patients who underwent pneumonectomy due to pN2 non-small cell lung cancer (NSCLC). Materials and Methods: A total of 45 patients who were determined to have pN2 disease after pneumonectomy between 2007 and 2016 were retrospectively analyzed. The patients were assigned a GPS between 0 and 2 as follows: elevated CRP level (>1.0 mg/dL) and hypoalbuminemia (<35 mg/dL) was classified as GPS 2, elevated CRP but albumin >35 mg/dL was classified as GPS 1, and CRP <1.0 mg/dl and albumin >35 mg/dL were classified as GPS 0. Results: Of the 45 patients included in the study, 42 (93.3%) were male and 3 (6.7%) were female. Eighteen (40%) of the patients had adenocarcinoma and 27 (60%) had squamous cell carcinoma. Skip pN2 (pN0N2) was detected in 10 patients. Mean follow-up time was 28 months. The 5-year survival rate was 40.2%. The main prognostic factors associated with survival were GPS and adjuvant therapy (p = 0.023, p = 0.001). Conclusions: In this study, there was no relationship between N1 status and survival in pneumonectomy patients with pN2 NSCLC, whereas GPS score and adjuvant therapy were found to be prognostically significant in terms of survival.

The Effect of Glasgow Prognostic Score And Systemic Inflammatory Index On Mortality In Patients With Postoperative Pneumonia

“…Kawashima et al reported that GPS was an independent prognostic factor in patients with operable lung cancer (25). Aker et al found that the GPS score was significant for survival in their study of patients undergoing pneumonectomy (26). According to the results of this study, the mortality of patients with postoperative GPS 2 was statistically significantly higher (p=0.03).…”

The comparison of the acute physiology and chronic health evaluation ii, sequential organ failure assessment and american society of anesthesiologists physical status classification scores in the prediction of morbidity and mortality after lung surgery

“…Despite advances in lung surgery, mortality and morbidity rates are still high [20][21][22]. The frequency of POC is affected by factors such as resection type, patient demographic characteristics, procedure duration, and intraoperative bleeding.…”

Cerrahi̇ Rezeksi̇yon Yapilan Küçük Hücreli̇ Dişi Akci̇ğer Kanserli̇ Kadin Hastalarda Sağkalima Etki̇ Eden Prognosti̇k Faktörler

“…Bu nedenle çalışmamızda heterojeniteyi azaltmak için segmentektomi hastaları ile lobektomi hastaları aynı grupta değerlendirilmiştir. Pnömonektomi uygulanmasının mortalite ve morbiditeyi arttırdığı daha önce yapılan çalışmalarda bildirilmiştir fakat tümör evresi ileri olan hastalarda komplet rezeksiyon sağlamak amacı ile uygulanmaktadır (17)(18)(19)(20). Calarella ve ark.…”