Prognostic value of histopathology and trends in cervical cancer: a SEER population study

Vinh-Hung, Vincent; Bourgain, Claire; Vlastos, Georges; Cserni, Gábor; Ridder, Mark De; Storme, Guy; Vlastos, Anne Thérèse

doi:10.1186/1471-2407-7-164

Cited by 196 publications

(188 citation statements)

References 66 publications

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“…Since some pathologic parameters are related to patients' prognosis, these parameters affect the plan of further treatment. [4][5][6] This means that pathologic findings of surgical specimens are important for the management of patients with cervical cancer. However, clinicians should consider preoperative diagnosis, because the stage of cervical cancer is clinically determined and clinicians can get much information related with prognosis from preoperative diagnosis.…”

Section: Discussionmentioning

confidence: 99%

Value of pelvic examination and imaging modality for the evaluation of tumor size in cervical cancer

et al. 2008

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Objective: The purpose of this study was to compare the accuracy of pelvic examination versus imaging modality such as computed tomography (CT) or magnetic resonance imaging (MRI) in the measurement of the tumor size of invasive cervical carcinoma based on pathologic findings. Methods: Patients with stage Ib-II cervical cancer who underwent primary surgical treatment between January 2003 and December 2005 were evaluated retrospectively. One hundred three consecutive patients aged 24 to 81 years (mean age, 50.6 years), who had not received any treatment previously were included in this study. Accuracy of preoperative CT or MRI versus pelvic examination in the measurement of tumor size was compared based on pathologic findings. All patients were examined and staged clinically by the gynecologic oncologist. Surgery was performed within 2 weeks after imaging studies. The data were analyzed using descriptive statistics. Results: The largest diameter of the tumor measured by pathologic findings was 2.76±1.76 cm. Based on pathologic findings, accuracy was estimated by the degree of agreement with a difference of ＜0.5 or 1.0 cm between the measurements of tumor size obtained by pelvic examination and imaging modality. Pelvic examination and imaging modality had an accuracy of 46.6% and 39.8%, respectively, with a difference of ＜0.5 cm, and an accuracy of 72.8% and 55.3%, respectively, with a difference of ＜1.0 cm. Correlation with pathologic findings was higher for pelvic examination (rs=0.680) than for imaging modality (rs=0.410). In determining the size of tumor mass differentiating ＞4.0 cm from ≤4.0 cm, imaging modality showed higher accuracy than pelvic examination. Conclusion: For the patients with stage Ib to II cervical cancer, pelvic examination is superior to imaging modality with regard to evaluation of the tumor size. However, imaging modality may be accurate for evaluating bulky tumors of cervical cancer.

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Section: Discussionmentioning

confidence: 99%

Value of pelvic examination and imaging modality for the evaluation of tumor size in cervical cancer

et al. 2008

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“…Several studies have reported that histological type is an important prognostic factor (Nakanishi et al, 2000;Takeda et al, 2002;Vinh-Hung et al, 2007;Chen et al, 2008;Zivanovic et al, 2009;Lee et al, 2010;Park et al, 2010). A US study of patients from 1997 to 2003 in the SEER database found 5-year overall survivals of 32.5% for patients with SNEC, 74.3% for ADC and 64.6% for SCC (Chen et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

“…The remaining cases consist of rare histological types including small cell neuroendocrine carcinoma (SNEC) (Kosary, 1994;Farley et al, 2003). Over time, the rates of invasive SCC have declined, while the incidence of 5356 ADC (Smith et al, 2000;Wang et al, 2004;Mathew and George, 2009) and SNEC (Vinh-Hung et al, 2007) have increased. A previous US study based on the Surveillance, Epidemiology, and End Results (SEER) data revealed a 42% reduction in age-adjusted incidence rates of SCC from 1973-1977 to 1993-1996, while the age-adjusted incidence rates of ADC increased by 29%.…”

Section: Introductionmentioning

confidence: 99%

“…Clarifying the prognostic impact of histological type is an essential issue that may influence the treatment and follow-up planning of newly diagnosed cervical cancer cases (Vinh-Hung et al, 2007). The aim of this study was to evaluate the prognostic impact of histological type on survival and mortality among patients with SCC, ADC and SNEC in Thailand.…”

Section: Introductionmentioning

confidence: 99%

“…These trends may be attributed to screening programs that have successfully detected pre-invasive SCC (Mathew and George, 2009). The increase in ADC probably results from an increased prevalence of HPV infection in the general population (Vinh-Hung et al, 2007), an insufficient of cytology screening program to detect pre-invasive lesions ADC (Smith et al, 2000;Liu et al, 2001) or the increased ability to diagnose the disease (Bray et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

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Prognostic Impact of Histology in Patients with Cervical Squamous Cell Carcinoma, Adenocarcinoma and Small Cell Neuroendocrine Carcinoma

Intaraphet

Kasatpibal²,

Siriaunkgul³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Cervical cancer is the third most common cancer among women worldwide, accounting for approximately 13% of all cancers in women, with 529,800 new cases and 275,100 deaths in 2008. More than 85% of the cases and about 88% of all deaths occurred in developing countries (Ferlay, 2010;Jemal et al., 2011). At the same time, the incidence of cervical cancer has decreased dramatically in developed countries with well-developed screening programs concomitant with substantial survival AbstractBackground: Clarifying the prognostic impact of histological type is an essential issue that may influence the treatment and follow-up planning of newly diagnosed cervical cancer cases. This study aimed to evaluate the prognostic impact of histological type on survival and mortality in patients with cervical squamous cell carcinoma (SCC), adenocarcinoma (ADC) and small cell neuroendocrine carcinoma (SNEC). Materials and Methods: All patients with cervical cancer diagnosed and treated at Chiang Mai University Hospital between January 1995 and October 2011 were eligible. We included all patients with SNEC and a random weighted sample of patients with SCC and ADC. We used competing-risks regression analysis to evaluate the association between histological type and cancer-specific survival and mortality. Results: Of all 2,108 patients, 1,632 (77.4%) had SCC, 346 (16.4%) had ADC and 130 (6.2%) had SNEC. Overall, five-year cancer-specific survival was 60.0%, 54.7%, and 48.4% in patients with SCC, ADC and SNEC, respectively. After adjusting for other clinical and pathological factors, patients with SNEC and ADC had higher risk of cancer-related death compared with SCC patients (hazard ratio [HR] 2.6; 95% CI, 1.9-3.5 and HR 1.3; 95% CI, 1.1-1.5, respectively). Patients with SNEC were younger and had higher risk of cancer-related death in both early and advanced stages compared with SCC patients (HR 4.9; 95% CI, 2.7-9.1 and HR 2.5; 95% CI, 1.7-3.5, respectively). Those with advanced-stage ADC had a greater risk of cancer-related death (HR 1.4; 95% CI, 1.2-1.7) compared with those with advanced-stage SCC, while no significant difference was observed in patients with early stage lesions. Conclusion: Histological type is an important prognostic factor among patients with cervical cancer in Thailand. Though patients with SNEC were younger and more often had a diagnosis of early stage compared with ADC and SCC, SNEC was associated with poorest survival. ADC was associated with poorer survival compared with SCC in advanced stages, while no difference was observed at early stages. Further tailored treatment-strategies and follow-up planning among patients with different histological types should be considered.

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Granulocyte‐colony stimulating factor‐producing uterine cervical cancer treated with chemoradiotherapy: A case report with mutation analysis and literature review

Shiba

Oike

Ando

et al. 2020

Clinical Case Reports

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Granulocyte-colony stimulating factor (G-CSF)-producing uterine cervical cancer (UCC) is a rare aggressive disease. We report a case of G-CSF-producing UCC treated with chemoradiotherapy. Target-capture sequencing results indicate that G-CSF-producing UCC is genetically distinct from other UCCs, warranting further research to establish specific treatment strategies. UCC is a common cancer that causes >311 000 deaths worldwide each year. 1 Advances in radiotherapy and chemotherapy have markedly improved the treatment outcomes of UCC. 2 Translational research efforts have provided information on the biological properties of tumors associated with treatment responses in patients with UCC, 3-5 which may help to personalize treatment strategies. Although UCC is a common cancer, a subset that produces G-CSF is rare. G-CSF-producing UCCs are highly aggressive. 6-13 However, specific patterns of care for G-CSF-producing UCCs have not been established, and treatment outcomes remain unknown because of the limited number of reported cases. Moreover, the mutation profile of G-CSF-producing UCC has not been analyzed. Here, we report a case of G-CSF-producing UCC, and the results of mutational analysis and literature review.

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Prognostic value of histopathology and trends in cervical cancer: a SEER population study

Abstract: Background: Histopathology is a cornerstone in the diagnosis of cervical cancer but the prognostic value is controversial.

Cited by 196 publications

References 66 publications

Value of pelvic examination and imaging modality for the evaluation of tumor size in cervical cancer

Value of pelvic examination and imaging modality for the evaluation of tumor size in cervical cancer

Prognostic Impact of Histology in Patients with Cervical Squamous Cell Carcinoma, Adenocarcinoma and Small Cell Neuroendocrine Carcinoma

Granulocyte‐colony stimulating factor‐producing uterine cervical cancer treated with chemoradiotherapy: A case report with mutation analysis and literature review

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