Prognostic value of immature platelet fraction and plasma thrombopoietin in disseminated intravascular coagulation

Hong, Ki Ho; Kim, Hyun Kyung; Kim, Ji Eun; Jung, Jae Seol; Han, Kyou Sup; Cho, Han Ik

doi:10.1097/mbc.0b013e32832b1866

Cited by 20 publications

(12 citation statements)

References 18 publications

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“…Alternatively, higher IPF levels in sepsis, and especially in patients with severe sepsis, might be a reflex of ongoing disseminated intravascular coagulation (DIC), which results in compensatory platelet production. In fact, IPF has been previously correlated with DIC scores in a cohort of critically-ill patients 24 . In our study, IPF did not correlate with coagulation tests such as prothrombin time, aPTT and D-dimer, but our study was not powered to draw any definite conclusion about this attractive mechanism of IPF increase during sepsis.…”

Section: Discussionmentioning

confidence: 97%

Association of the immature platelet fraction with sepsis diagnosis and severity

Hubert

Rodrigues

Andreguetto

et al. 2015

Sci Rep

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Management of Sepsis would greatly benefit from the incorporation of simple and informative new biomarkers in clinical practice. Ideally, a sepsis biomarker should segregate infected from non-infected patients, provide information about prognosis and organ-specific damage, and be accessible to most healthcare services. The immature platelet fraction (IPF) and immature reticulocyte fraction (IRF) are new analytical parameters of the complete blood count, that have been studied as biomarkers of several inflammatory conditions. Recently, a study performed in critically-ill patients suggested that IPF could be a more accurate sepsis biomarker than C-reactive protein (CRP) and procalcitonin. In this retrospective study we evaluated the performance of IPF and IRF as biomarkers of sepsis diagnosis and severity. 41 patients admitted to two intensive care units were evaluated, 12 of which with severe sepsis or septic shock, and 11 with non-complicated sepsis. Significantly higher IPF levels were observed in patients with severe sepsis/ septic shock. IPF correlated with sepsis severity scores and presented the highest diagnostic accuracy for the presence of sepsis of all studied clinical and laboratory parameters. No significant differences were observed in IRF levels. Our results suggest that IPF levels could be used as a biomarker of sepsis diagnosis and severity.

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Section: Discussionmentioning

confidence: 97%

Association of the immature platelet fraction with sepsis diagnosis and severity

Hubert

Rodrigues

Andreguetto

et al. 2015

Sci Rep

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“…The IPF has been used as a prognostic indicator in DIC [9] and acute coronary syndrome. Recent studies have evaluated the value of IPF measurements in patients with bacterial infection and sepsis.…”

Section: Immature Platelet Fraction (Ipf)mentioning

confidence: 99%

Understanding platelet dysfunction in sepsis

et al. 2015

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“…In one recent study, both were significantly increased in overt DIC as well as correlating with the DIC score using the ISTH overt DIC criteria. 61 Moreover, the presence of reticulated platelets correlated with FDPs, and both the immature platelet fraction and plasma thrombopoietin showed better mortality prediction than platelet count.…”

Section: Additional Platelet-related Parametersmentioning

confidence: 93%

Laboratory Testing in Disseminated Intravascular Coagulation

Favaloro

2010

Semin Thromb Hemost

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The diagnosis of disseminated intravascular coagulation (DIC) relies on clinical signs and symptoms, identification of the underlying disease, the results of laboratory testing, and differentiation from other pathologies. The clinical features mainly depend on the underlying cause of the DIC. The laboratory diagnosis of DIC uses a combination of tests because no single test result alone can firmly establish or rule out the diagnosis. Global tests of hemostasis may initially provide evidence of coagulation activation and later in the process provide evidence of consumption of coagulation factors, but their individual diagnostic efficiency is limited. Fibrinolytic markers, in particular D-dimer, are reflective of activation of both coagulation and fibrinolysis, so that a normal finding can be useful for ruling-out DIC. Decreased levels of the natural anticoagulants (in particular, antithrombin and protein C) are frequently observed in patients with DIC, but their measurement is not normally incorporated into standard diagnostic algorithms. New tests are being explored for utility in DIC, and some additional tests may be useful on a case-by-case basis, depending on the proposed cause of the DIC or their local availability. For example, clot waveform analysis is useful but currently limited to a single instrument. Also, procalcitonin is an inflammatory biomarker that may be useful within the context of septic DIC, and activated factor X clotting time is an emerging test of procoagulant phospholipids that also seems to hold promise in DIC.

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Prognostic value of immature platelet fraction and plasma thrombopoietin in disseminated intravascular coagulation

Cited by 20 publications

References 18 publications

Association of the immature platelet fraction with sepsis diagnosis and severity

Association of the immature platelet fraction with sepsis diagnosis and severity

Understanding platelet dysfunction in sepsis

Laboratory Testing in Disseminated Intravascular Coagulation

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