Prognostic value of inflammatory biomarkers in aged patients with oral squamous cell carcinoma

Abstract

Background: Better prognostic biomarkers for oral squamous cell carcinoma (OSCC) must be developed, particularly within the realm of clinically and frequently administered tests, to advise appropriate clinical therapy and follow-up. In this study, we retrospectively investigated which of the several inflammation-nutrition indicators might predict the prognosis of patients with OSCC.Methods: The preoperative neutrophil-lymphocyte ratio (NLR), lymphocyte–monocyte ratio (LMR), platelet–lymphocyte ratio (PLR), CRP-albumin ratio (CAR), Glasgow prognostic score (GPS), modified GPS (mGPS), prognostic nutritional index (PNI), controlling nutrition status (CONUT), and modified CONUT (mCONUT) were retrospectively evaluated using blood samples collected 1–5 days before surgery. To estimate the effect on the prognosis of tumor progression, the mean values of the markers between stages I/II and III/IV were used for subgroup analysis. The multivariate Cox proportional hazards model included all independent variables significantly associated with survival in the univariate analysis to determine the independent variables.Results: A total of 112 patients (69 males and 43 females) with primary OSCC who underwent surgical treatment at our hospital were included. There were statistically significant differences in the mean values of monocytes, platelets, and albumin between stages I/II and III/IV. According to the multivariate Cox proportional hazards regression, a low PNI was associated with shorter overall survival (OS) and disease-free survival (DFS); women were associated with shorter DFS.Conclusion: The pretreatment PNI had excellent predictive value for the 5-year OS and DFS of patients with OSCC. Future large-scale prospective studies with a high sample size are needed to verify our findings in OSCC patients.

Prognostic and clinicopathological role of pretreatment systemic immune-inflammation index in patients with oral squamous cell carcinoma: a meta-analysis

“…They found that a low PNI was associated with shorter OS and DFS in patients with OSCC through multivariate analysis ( 38 ). Although that study did not include SII for analysis in OSCC, their results were important to investigate mechanisms ( 38 ). In peripheral blood analyses, inflammation-related markers were mainly composed of upregulated factors (neutrophils, platelets, monocytes, and CRP) and downregulated factors (lymphocytes, albumin, total cholesterol, and hemoglobin).…”

“…Notably, a recent single study by Yoshimura et al investigated the prognostic effect of multiple inflammation-nutrition parameters including NLR, PLR, LMR, CRP-albumin ratio (CAR), Glasgow prognostic score (GPS), modified GPS (mGPS), prognostic nutritional index (PNI), controlling nutrition status (CONUT), and modified CONUT (mCONUT) in patients with OSCC receiving surgery (38). They found that a low PNI was associated with shorter OS and DFS in patients with OSCC through multivariate analysis (38). Although that study did not include SII for analysis in OSCC, their results were important to investigate mechanisms (38).…”

Genome-wide Mendelian Randomization analysis reveals specific inflammatory traits as causal risk factors for oral cancer

“…Speci cally, subtypes of in ammatory bowel disease, such as Crohn's disease and ulcerative colitis, have been linked to this heightened risk. Additionally, various in ammatory markers have been investigated in relation to oral cancer risk [9,10]. Elevated levels of pro-in ammatory factors, including interleukin (IL)-6, IL-27, and tumor necrosis factor (TNF)-α, have been observed in individuals with oral cancer [11,12].…”

Nomogram incorporating potent inflammatory indicators for overall survival estimation of patients with primary oral squamous cell carcinoma

“…Abundant and compelling evidence has demonstrated that inflammation facilitates angiogenesis, tumor invasion and metastasis by supplying bioactive molecules to the tumor environment (9). The cancer-associated systemic inflammatory response has become a critical indicator of tumor progression (10)(11)(12). Subsequently, biomarkers reflecting the level of systemic inflammation blossom, producing a wide range of circulating blood cell count-based inflammatory markers that have helped refine prognosis prediction when incorporated with TNM system in multiple malignancies (13,14).…”