Prognostic value of ischaemia-modified albumin in patients with non-ST-segment elevation acute coronary syndromes

Bali, Laurent; Cuisset, Thomas; Giorgi, Roch; Monserrat, Colette; Quilici, Jacques; Carrega, Louis; Mouret, Jean-Philippe; Nait-Saïdi, Lyassine; Mielot, Christopher; Lambert, Marc; Guieu, Régis; Bonnet, Jean‐Louis

doi:10.1016/j.acvd.2008.09.005

Cited by 21 publications

(10 citation statements)

References 24 publications

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“…Blood sampling was processed as described using laboratory‐prepared tubes containing 3 ml of cold‐stop solution composed of inhibitors of degradation and red blood cell uptake of adenosine [36,39,41]. Samples were then maintained on ice until centrifugation.…”

Section: Methodsmentioning

confidence: 99%

Search for adenosine A_2A spare receptors on peripheral human lymphocytes

Jacquin

Franceschi

et al. 2012

FEBS Open Bio

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Some ligand–receptor couples involve spare receptors, which are apparent when a maximal response is achieved with only a small fraction of the receptor population occupied. This situation favours cross-reactions with low-affinity ligands, which may be detrimental for cell signaling. In the case of the adenosine A2A receptors (A2AR), which have an immunosuppressive effect on lymphocytes through cAMP production, the presence of spare A2AR remains to be established. We examined the situation using patients over-expressing lymphocyte A2AR and an agonist-like mAb to A2AR. We found that maximal mAb binding and functional response varied among the patients whereas the dissociation constant and half-maximal effective concentration had similar mean values (0.19 and 0.18 μM, respectively). Lymphocyte A2AR expression was correlated to plasma adenosine level and A2AR occupation but not to A2AR response. These results are consistent with a lack of a reserve of functional A2AR on human lymphocytes as a general rule and suggest that the amount and functional state of the expressed A2AR determine the maximal level of the lymphocyte response to adenosine.

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Section: Methodsmentioning

confidence: 99%

Search for adenosine A_2A spare receptors on peripheral human lymphocytes

Jacquin

Franceschi

et al. 2012

FEBS Open Bio

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“…The groups that participate in this binding have been shown to be the α-amino group, the two intervening peptide nitrogen atoms, the δ-imidazole nitrogen from His3 and the side-chain carboxyl group of Asp1 [8]. In the presence of ischemia, structural changes take place in the N-terminus of albumin that rapidly reduce its binding capacity for transition metal ions, Co 2+ and Ni 2+ [9,10]. IMA is a marker formed after damage in the N-terminal region of albumin.…”

Section: Structure Of Imamentioning

confidence: 98%

“…Bali et al [9] demonstrated that the independent prognostic value of IMA was greater than that of conventional markers such as Tn-I and C-reactive protein for non-STsegment elevation (NSTE) ACS patients. The small sample size was mentioned as being a limitation of the study (n = 79).…”

Section: Use Of Ima In Acsmentioning

confidence: 98%

“…In their conclusion, baseline IMA level was associated with both short-and long-term recurrent ischemic events in patients admitted to the hospital for NSTE ACS. In addition, a cutoff of 109 U/mL had a good negative predictive value and could be used in daily clinical practice [9]. Behera et al [24] aimed to evaluate the diagnostic efficacy of IMA and its correlation with lipid profile and oxidative stress in acute MI patients admitted to the ED.…”

Section: Use Of Ima In Acsmentioning

confidence: 99%

“…Then, dithiothreitol is added to react with the cobalt not bound to the N-terminus to form a measurable color. The absorbance is measured by spectrophotometer [9]. Blood samples need to be analyzed rapidly to avoid sample dilutions.…”

Section: Analysis Of Imamentioning

confidence: 99%

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Role of ischemia-modified albumin in clinical practice

Erenler

Yardan

Katı

et al. 2015

LaboratoriumsMedizin

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Difficulty in establishing a diagnosis of acute coronary syndrome (ACS) in the clinical setting has led researchers to investigate novel markers that show increased blood levels before the myocardial necrosis occurs. In ischemic conditions, some modifications occur in the amino acids located on the N-terminus of the human albumin molecule. Ischemia-modified albumin (IMA) is a marker formed after damage in the N-terminal region of albumin. The altered N-terminus can no longer bind transition metals, such as cobalt. The causes of the increases in IMA have been shown to be endothelial or extracellular hypoxia, acidosis, and free oxygen radicals. IMA, an early marker of ischemic disorders, is also a candidate marker for the detection of ACS. An assay measuring IMA might represent a promising marker for the identification of patients with myocardial ischemia. The aim of this study was to evaluate the clinical utility of IMA in the assessment of ACS as well as other medical disorders in light of the recent literature.

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Physiology, pathophysiology and (mal)adaptations to chronic apnoeic training: a state-of-the-art review

et al. 2021

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Breath-hold diving is an activity that humans have engaged in since antiquity to forage for resources, provide sustenance and to support military campaigns. In modern times, breath-hold diving continues to gain popularity and recognition as both a competitive and recreational sport. The continued progression of world records is somewhat remarkable, particularly given the extreme hypoxaemic and hypercapnic conditions, and hydrostatic pressures these athletes endure. However, there is abundant literature to suggest a large inter-individual variation in the apnoeic capabilities that is thus far not fully understood. In this review, we explore developments in apnoea physiology and delineate the traits and mechanisms that potentially underpin this variation. In addition, we sought to highlight the physiological (mal)adaptations associated with consistent breath-hold training. Breath-hold divers (BHDs) are evidenced to exhibit a more pronounced diving-response than non-divers, while elite BHDs (EBHDs) also display beneficial adaptations in both blood and skeletal muscle. Importantly, these physiological characteristics are documented to be primarily influenced by training-induced stimuli. BHDs are exposed to unique physiological and environmental stressors, and as such possess an ability to withstand acute cerebrovascular and neuronal strains. Whether these characteristics are also a result of training-induced adaptations or genetic predisposition is less certain. Although the long-term effects of regular breath-hold diving activity are yet to be holistically established, preliminary evidence has posed considerations for cognitive, neurological, renal and bone health in BHDs. These areas should be explored further in longitudinal studies to more confidently ascertain the long-term health implications of extreme breath-holding activity.

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Prognostic value of ischaemia-modified albumin in patients with non-ST-segment elevation acute coronary syndromes

Abstract: Baseline levels of IMA were associated with both short- and long-term cardiovascular (CV) events in patients admitted for NSTE ACS.

Cited by 21 publications

References 24 publications

Search for adenosine A_2A spare receptors on peripheral human lymphocytes

Search for adenosine A_2A spare receptors on peripheral human lymphocytes

Role of ischemia-modified albumin in clinical practice

Physiology, pathophysiology and (mal)adaptations to chronic apnoeic training: a state-of-the-art review

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Prognostic value of ischaemia-modified albumin in patients with non-ST-segment elevation acute coronary syndromes

Abstract: Baseline levels of IMA were associated with both short- and long-term cardiovascular (CV) events in patients admitted for NSTE ACS.

Cited by 21 publications

References 24 publications

Search for adenosine A2A spare receptors on peripheral human lymphocytes

Search for adenosine A2A spare receptors on peripheral human lymphocytes

Role of ischemia-modified albumin in clinical practice

Physiology, pathophysiology and (mal)adaptations to chronic apnoeic training: a state-of-the-art review

Contact Info

Product

Resources

About

Search for adenosine A_2A spare receptors on peripheral human lymphocytes

Search for adenosine A_2A spare receptors on peripheral human lymphocytes