Prognostic value of jaundice in patients with gallbladder cancer by the AFC-GBC-2009 study group

Régimbeau, Jean-Marc; Fuks, David; Bachellier, P.; Treut, Yves Patrice Le; Pruvot, François‐René; Navarro, Francis; Chiche, Laurence; Farges, Olivier

doi:10.1016/j.ejso.2011.03.135

Cited by 75 publications

(91 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Although obstructive jaundice and lymph node involvement are reported as predictors of poor prognosis, surgical resection may improve the prognosis of patients with these factors [117,118].…”

Section: Cq16: What Are Considered As Unresectable Factors In Biliarymentioning

confidence: 99%

Clinical practice guidelines for the management of biliary tract cancers 2015: the 2^nd English edition

Miyazaki

Yoshitomi

Miyakawa³

et al. 2015

J Hepato Biliary Pancreat

237

165

View full text Add to dashboard Cite

Background The Japanese Society of Hepato-Biliary-Pancreatic Surgery launched the clinical practice guidelines for the management of biliary tract and ampullary carcinomas in 2008. Novel treatment modalities and handling of clinical issues have been proposed after the publication. New approaches for editing clinical guidelines, such as the Grading of Recommendations Assessment, Development and Evaluation (GRADE) system, also have been introduced for better and clearer grading of recommendations. Methods Clinical questions (CQs) were proposed in seven topics. Recommendation, grade of recommendation and statement for each CQ were discussed and finalized by evidencebased approach. Recommendation was graded to grade 1 (strong) and 2 (weak) according to the concept of GRADE system. Results The 29 CQs covered seven topics: (1) prophylactic treatment, (2) diagnosis, (3) biliary drainage, (4) surgical treatment, (5) chemotherapy, (6) radiation therapy, and (7) pathology. In 27 CQs, 19 recommendations were rated strong and 11 recommendations weak. Each CQ included the statement of how the recommendation was graded. Conclusions This guideline provides recommendation for important clinical aspects based on evidence. Future collaboration with cancer registry will be a key for assessment of the guidelines and establishment of new evidence. Free full-text articles and a mobile application of this guideline are available via

show abstract

Section: Cq16: What Are Considered As Unresectable Factors In Biliarymentioning

confidence: 99%

Clinical practice guidelines for the management of biliary tract cancers 2015: the 2^nd English edition

Miyazaki

Yoshitomi

Miyakawa³

et al. 2015

J Hepato Biliary Pancreat

237

165

View full text Add to dashboard Cite

show abstract

“…Even when patients with GBC presented with jaundice, the 5-year OS rate was 27%, and MST was 1.9 years, and some survived for 5 years. However, many reports describe that jaundice arising in patients with GBC indicates advanced disease and some believe that this precludes routine operative exploration [8,[15][16][17] . The difference between the present (4) 1 ( and these findings is that we achieved higher curative resection rates.…”

Section: Discussionmentioning

confidence: 99%

Aggressive Surgery for Locally Advanced Gallbladder Cancer with Obstructive Jaundice: Result of a Prospective Study

Nasu

Hirano²,

Tsuchikawa³

et al. 2016

Dig Surg

View full text Add to dashboard Cite

Objective: The aim of this study was to clarify the clinical impact of our departmental policy for advanced gallbladder cancer (GBC) even with obstructive jaundice. Methods: Obstructive jaundice was defined as serum T-bil ≥2.0 mg/dl. Between 1998 and 2008, 112 patients with GBC were scheduled for surgical resection with curative intent. Thirty-six patients were converted to palliative surgery or exploration alone because of advanced disease. After excluding pathological T1 (UICC) patients (n = 11), the remaining 65 patients were divided into 2 groups; jaundiced group (n = 37) and non-jaundiced group (n = 28). Surgical procedures were conducted based on our departmental guidelines concerning each type of infiltration of GBC. Results: Bile duct resection and major hepatectomy were performed more frequently in patients with jaundice. Although patients in jaundiced group had more advanced disease, 5-year overall survival rates of the patients with or without jaundice were 27 vs. 31% (p = 0.742), which was not statistically significant. Conclusions: Aggressive surgery might improve long-term survival in patients with locally advanced GBC even in the condition of obstructive jaundice with no distant metastasis.

show abstract

“…Other Surgical Considerations Preoperative Jaundice while jaundice is a poor prognostic factor in patients with gallbladder cancer, the presence of jaundice does not necessarily preclude operative intervention as long as negative margins may be achieved. 80 Feng et al…”

Section: 77mentioning

confidence: 99%

Gallbladder Cancer—Current Management Options

Ejaz¹,

Sachs²,

Kamel³

et al. 2013

Oncology &Amp; Hematology Review (US)

View full text Add to dashboard Cite

Abstractcarcinoma of the gallbladder is an aggressive disease, often with a poor prognosis. although the incidence has remained relatively stable over the past decade, an increase in laparoscopic cholecystectomy has resulted in a increase in cases detected at earlier stages offering an opportunity for better prognosis. diagnostic techniques including ultrasound (uS), endoscopic uS (EuS), computed tomography (cT) with multiplanar reconstruction, magnetic resonance imaging (MRi), positron emission tomography (PET), and diagnostic laparoscopy have evolved. Surgical resection to negative microscopic margins with lymphadenectomy offers the only chance for long-term survival. adjuvant chemotherapy and radiation may be indicated in a subset of patients, and data have suggested a beneficial effect on overall survival. a multidisciplinary approach is required for the optimal management of this complex disease. KeywordsGallbladder cancer, biliary tract cancer Incidence/EpidemiologyGallbladder cancer is the fifth most common gastrointestinal malignancy in the uS and the most common cancer of the biliary system. 1 it has an incidence of approximately one to two per 100,000 people, with approximately five to six thousand new cases per year, as estimated by the Surveillance, Epidemiology and End Results (SEER) database. While showing a small decrease in overall incidence over the past 10 years, the incidence in younger populations is growing. Socioeconomic status and access to cholecystectomy have been shown to relate to the incidence gallbladder cancer. 2 its incidence is higher in South american countries, especially chile, and in populations where cholelithiasis is prevalent. 3,4 The incidence of gallbladder cancer is increasing in china and other countries where westernization of diet and increasing obesity are thought to play a role. 5,6Between 10 and 15 % of the adult uS population is affected by cholelithiasisthe number one risk factor for all biliary cancers-and over 750,000cholecystectomies are performed annually in the uS. 7 This has led to an increase in incidentally detected gallbladder cancers, of which approximately 80 % are stage i or ii. 8 it has been estimated that gallbladder cancer found incidentally after cholecystectomy occurs in 0.2-2.9 % of cases, representinganywhere from 40 to 70 % of all gallbladder cancer diagnoses. 9,10Demographics a number of demographic variables play a role in gallbladder cancer.Females have a 40 to 60 % higher incidence of gallbladder cancer than men. 7 Race and ethnicity also play a role, with incidence highest in caucasian hispanics and Native americans, and lowest in non-hispanic caucasians and african americans. The incidence of gallbladder cancer also increases with age, with mean diagnosis in the seventh decade of life. 11 Risk Factorschronic inflammation of the gallbladder is the most identifiable cause for development of gallbladder cancer. 3 While this is most often due to cholelithiasis, any disease process that causes chronic inflammation of the gallbladder will ...

show abstract

Prognostic value of jaundice in patients with gallbladder cancer by the AFC-GBC-2009 study group

Cited by 75 publications

References 17 publications

Clinical practice guidelines for the management of biliary tract cancers 2015: the 2^nd English edition

Clinical practice guidelines for the management of biliary tract cancers 2015: the 2^nd English edition

Aggressive Surgery for Locally Advanced Gallbladder Cancer with Obstructive Jaundice: Result of a Prospective Study

Gallbladder Cancer—Current Management Options

Contact Info

Product

Resources

About

Prognostic value of jaundice in patients with gallbladder cancer by the AFC-GBC-2009 study group

Cited by 75 publications

References 17 publications

Clinical practice guidelines for the management of biliary tract cancers 2015: the 2nd English edition

Clinical practice guidelines for the management of biliary tract cancers 2015: the 2nd English edition

Aggressive Surgery for Locally Advanced Gallbladder Cancer with Obstructive Jaundice: Result of a Prospective Study

Gallbladder Cancer—Current Management Options

Contact Info

Product

Resources

About

Clinical practice guidelines for the management of biliary tract cancers 2015: the 2^nd English edition

Clinical practice guidelines for the management of biliary tract cancers 2015: the 2^nd English edition