Prognostic value of left ventricular global longitudinal strain in chronic kidney disease patients: a systematic review and meta-analysis

Zhang, Tao; Li, Jing; Shi-li, Cao

doi:10.1007/s11255-020-02492-0

Cited by 11 publications

(10 citation statements)

References 41 publications

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“…This confirms the findings of previous studies that strain imaging-derived GLS precedes changes in EF observed by conventional echocardiography [ 29 – 31 ]. GLS has been shown to be a predictor of all-cause and cardiovascular mortality in several studies [ 7 , 32 , 33 ]. However, there was no difference in GLS between the DKD and NDKD groups in our study.…”

Section: Discussionmentioning

confidence: 99%

“…There is also a growing body of evidence that deformation analysis by speckle-tracking echocardiography (also called strain imaging) can identify cardiac abnormalities earlier than conventional echocardiographic techniques. This modality could potentially transform our understanding of cardiomyopathy in CKD, help in prognostication, and improve therapeutic decision-making [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

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A comparative analysis of conventional and speckle-tracking strain echocardiographic findings in diabetic and non-diabetic kidney disease patients with normal ejection fraction

Paramasivam

Rao

Samanth

et al. 2022

Int J Cardiovasc Imaging

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This study aimed to compare the differences in echocardiographic and strain parameters in patients with diabetic kidney disease (DKD) and non-diabetic kidney disease (NDKD) in a cohort with pre-dialysis chronic kidney disease (CKD) and normal ejection fraction (EF). In this single-center prospective study, patients with CKD stages 3–5 and EF > 55% were included. We compared cardiac structure and function using conventional and speckle-tracking strain echocardiography among DKD and NDKD groups. Cardiovascular outcomes were assessed at the end of the study. Of the included 117 patients, 56 (47.9%) had DKD, and 61 (52.1%) had NDKD. Patients with DKD had higher ratios of early mitral inflow velocity and mitral annular early diastolic velocity (E/e’) (11.9 ± 4.4 vs. 9.8 ± 3.5; p = 0.004), lower septal e’ velocity (7.1 ± 2.5 vs. 8.2 ± 2.8; p = 0.031), lower lateral e’ velocity (9.2 ± 2.9 vs. 10.4 ± 3.8; p = 0.045) and longer deceleration times (209.2 ± 41.5 vs. 189.1 ± 48.0; p = 0.017), compared to those with NDKD. Left ventricular mass index (LVMI), global longitudinal strain (GLS), early diastolic strain rate (SRE), and E/SRE were similar. At a median follow-up of 239 days, 3-P MACE (11.5% vs. 4.9%; p = 0.047) and 4-P MACE (28.6% vs. 11.5%; p = 0.020) were observed to be higher in the DKD group. Diastolic dysfunction was more common in patients with DKD, compared to those with NDKD, although both groups had similar LVMI and GLS. Those with DKD also had poorer cardiovascular outcomes. This highlights the importance of the assessment of diastolic function in CKD, particularly in those with diabetic CKD.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A comparative analysis of conventional and speckle-tracking strain echocardiographic findings in diabetic and non-diabetic kidney disease patients with normal ejection fraction

Paramasivam

Rao

Samanth

et al. 2022

Int J Cardiovasc Imaging

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“…Chronic kidney disease (CKD) is characterized as a reduction of glomerular filtration rate and/or increased urinary albumin excretion (Jha et al, 2013), and affects 10-15% of adults worldwide (Zhang et al, 2020d). In Brazil, the prevalence of CKD is approximately 500 per million individuals (Jha et al, 2013).…”

Section: Chronic Kidney Disease (Ckd)mentioning

confidence: 99%

MASPs at the crossroad between the complement and the coagulation cascades - the case for COVID-19

et al. 2021

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Components of the complement system and atypical parameters of coagulation were reported in COVID-19 patients, as well as the exacerbation of the inflammation and coagulation activity. Mannose binding lectin (MBL)-associated serine proteases (MASPs) play an important role in viral recognition and subsequent activation of the lectin pathway of the complement system and blood coagulation, connecting both processes. Genetic variants of MASP1 and MASP2 genes are further associated with different levels and functional efficiency of their encoded proteins, modulating susceptibility and severity to diseases. Our review highlights the possible role of MASPs in SARS-COV-2 binding and activation of the lectin pathway and blood coagulation cascades, as well as their associations with comorbidities of COVID-19. MASP-1 and/or MASP-2 present an increased expression in patients with COVID-19 risk factors: diabetes, arterial hypertension and cardiovascular disease, chronic kidney disease, chronic obstructive pulmonary disease, and cerebrovascular disease. Based also on the positive results of COVID-19 patients with anti-MASP-2 antibody, we propose the use of MASPs as a possible biomarker of the progression of COVID-19 and the investigation of new treatment strategies taking into consideration the dual role of MASPs, including MASP inhibitors as promising therapeutic targets against COVID-19.

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“…In this context, new echocardiographic techniques such as two-dimensional speckle-tracking echocardiography have recently opened the possibility of performing more accurate assessments of the systolic function by evaluating the deformation of myocardial fibers [ 15 ]. Furthermore, growing evidence suggests that global longitudinal strain (GLS) could be a more sensitive marker of systolic dysfunction of the left ventricle and even provide a more accurate cardiovascular prognosis than ejection fraction in several contexts [ 16 , 17 ]. The assessment of the patterns of left-ventricle involvement by segments using speckle tracking strain could, in addition, be critical for identifying patients with early myocardial involvement and those at risk of developing CCM [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Longitudinal Speckle Tracking Strain Abnormalities in Chagas Disease: A Systematic Review and Meta-Analysis

Gómez‐Ochoa

Rojas

Vargas³

et al. 2022

JCM

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Background: Chronic Chagas cardiomyopathy (CCM) is ranked among heart failure etiologies with the highest mortality rates. CCM is characterized by alterations in left ventricular function with a typical and unique pattern of myocardial involvement. Left ventricle longitudinal speckle tracking strain is emerging as an important additive method for evaluating left ventricular function and risk of future cardiovascular events. This systematic review aimed to characterize the left ventricle (LV) longitudinal strain by speckle tracking patterns in the different stages of Chagas disease, compared to healthy controls. Methods: Searches in Medline, EMBASE, and LILACS databases (from inception to 20 May 2021) were performed. Articles written in any language that assessed patients with Chagas disease and reported any measures derived from the left ventricular strain by speckle tracking were included. Two reviewers independently selected the studies, extracted the data, and assessed the quality of evidence. Standardized mean differences (SMD) were pooled using random-effects meta-analyses. Results: Of 1044 references, ten studies, including a total of 1222 participants (CCM: 477; indeterminate form: 444; healthy controls: 301), fulfilled the selection criteria and were included in the final analysis. Patients with CCM had a significantly higher mean global longitudinal strain (GLS) value than indeterminate form (IF) patients (SMD 1.253; 95% CI 0.53, 1.98. I2 = 94%), while no significant difference was observed between IF patients and healthy controls (SMD 0.197; 95% CI −0.19, 0.59. I2 = 80%). Segmental strain analyses revealed that patients with the IF form of CD had significantly worse strain values in the basal-inferoseptal (SMD 0.49; 95% CI 0.24, 0.74. I2: 24%), and mid-inferoseptal (SMD 0.28; 95% CI 0.05, 0.50. I2: 10%) segments compared to healthy controls. Conclusions: Our results suggest different levels of functional derangements in myocardial function across different stages of Chagas disease. Further research is needed to assess the prognostic role of LV longitudinal strain and other measures derived from speckle tracking in CD patients regarding progression to cardiomyopathy and clinical outcomes prediction.

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Prognostic value of left ventricular global longitudinal strain in chronic kidney disease patients: a systematic review and meta-analysis

Cited by 11 publications

References 41 publications

A comparative analysis of conventional and speckle-tracking strain echocardiographic findings in diabetic and non-diabetic kidney disease patients with normal ejection fraction

A comparative analysis of conventional and speckle-tracking strain echocardiographic findings in diabetic and non-diabetic kidney disease patients with normal ejection fraction

MASPs at the crossroad between the complement and the coagulation cascades - the case for COVID-19

Longitudinal Speckle Tracking Strain Abnormalities in Chagas Disease: A Systematic Review and Meta-Analysis

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