Prognostic value of liver stiffness measurement in patients with hepatocellular carcinoma (HCC) treated by radiofrequency ablation: a meta-analysis

Zhang, Yongchao; Chen, Hualei; Chen, Shanshan; Li, Wei

doi:10.1080/02656736.2021.1947529

Cited by 7 publications

(5 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Changes in ECM composition are one of the characterizing features of the TME and it is widely accepted that this actively contributes to disease progression in different tumors 20,21 . This significance of altered ECM is seen in HCC patients, where increases in liver stiffness are associated with hepatic dysfunction, poor prognosis, and survival [22][23][24] . Recent studies have even shown that increased liver stiffness is a predictor for mortality and need for mechanical ventilation among patients hospitalized with COVID-19 25 .…”

Section: Discussionmentioning

confidence: 99%

Influence of extracellular matrix composition on tumour cell behaviour in a biomimetic in vitro model for hepatocellular carcinoma

Calitz

Rosenquist

Degerstedt

et al. 2023

Sci Rep

View full text Add to dashboard Cite

The tumor micro-environment (TME) of hepatocellular carcinoma (HCC) consists out of cirrhotic liver tissue and is characterized by an extensive deposition of extracellular matrix proteins (ECM). The evolution from a reversible fibrotic state to end-stage of liver disease, namely cirrhosis, is characterized by an increased deposition of ECM, as well as changes in the exact ECM composition, which both contribute to an increased liver stiffness and can alter tumor phenotype. The goal of this study was to assess how changes in matrix composition and stiffness influence tumor behavior. HCC-cell lines were grown in a biomimetic hydrogel model resembling the stiffness and composition of a fibrotic or cirrhotic liver. When HCC-cells were grown in a matrix resembling a cirrhotic liver, they increased proliferation and protein content, compared to those grown in a fibrotic environment. Tumour nodules spontaneously formed outside the gels, which appeared earlier in cirrhotic conditions and were significantly larger compared to those found outside fibrotic gels. These tumor nodules had an increased expression of markers related to epithelial-to-mesenchymal transition (EMT), when comparing cirrhotic to fibrotic gels. HCC-cells grown in cirrhotic gels were also more resistant to doxorubicin compared with those grown in fibrotic gels or in 2D. Therefore, altering ECM composition affects tumor behavior, for instance by increasing pro-metastatic potential, inducing EMT and reducing response to chemotherapy.

show abstract

Section: Discussionmentioning

confidence: 99%

Influence of extracellular matrix composition on tumour cell behaviour in a biomimetic in vitro model for hepatocellular carcinoma

Calitz

Rosenquist

Degerstedt

et al. 2023

Sci Rep

View full text Add to dashboard Cite

show abstract

“…Transaminases, albumin, and prothrombin time were closely related to the degree of liver inflammation, while liver stiffness was associated with liver fibrosis, inflammation, and portal pressure. Therefore, the inflammatory state of the liver and the pressure of the portal vein could affect LSM measurements, thus, it may affect the accuracy of liver fibrosis assessment [ 30 – 31 ].…”

Section: Discussionmentioning

confidence: 99%

Construction of a nomogram for predicting compensated cirrhosis with Wilson’s disease based on non-invasive indicators

Li,

Wang,

Zhu

2024

BMC Med Imaging

View full text Add to dashboard Cite

Background Wilson’s disease (WD) often leads to liver fibrosis and cirrhosis, and early diagnosis of WD cirrhosis is essential. Currently, there are few non-invasive prediction models for WD cirrhosis. The purpose of this study is to non-invasively predict the occurrence risk of compensated WD cirrhosis based on ultrasound imaging features and clinical characteristics. Methods A retrospective analysis of the clinical characteristics and ultrasound examination data of 102 WD patients from November 2018 to November 2020 was conducted. According to the staging system for WD liver involvement, the patients were divided into a cirrhosis group (n = 43) and a non-cirrhosis group (n = 59). Multivariable logistic regression analysis was used to identify independent influencing factors for WD cirrhosis. A nomogram for predicting WD cirrhosis was constructed using R analysis software, and validation of the model’s discrimination, calibration, and clinical applicability was completed. Due to the low incidence of WD and the small sample size, bootstrap internal sampling with 500 iterations was adopted for validation to prevent overfitting of the model. Results Acoustic Radiation Force Impulse (ARFI), portal vein diameter (PVD), and serum albumin (ALB) are independent factors affecting WD cirrhosis. A nomogram for WD cirrhosis was constructed based on these factors. The area under the ROC curve (AUC) of the model’s predictive ability is 0.927 (95% CI: 0.88–0.978). As demonstrated by 500 Bootstrap internal sampling validations, the model has high discrimination and calibration. Clinical decision curve analysis shows that the model has high clinical practical value. ROC curve analysis of the model’s rationality indicates that the model’s AUC is greater than the AUC of using ALB, ARFI, and PVD alone. Conclusion The nomogram model constructed based on ARFI, PVD, and ALB can serve as a non-invasive tool to effectively predict the risk of developing WD cirrhosis.

show abstract

“…They suggested that ARFI imaging is a useful tool for assessing liver functional reserve. As another example, a recent meta-analysis reported that ARFI scores may be a good predictor of HCC recurrence-free survival in patients receiving radiofrequency ablation[ 24 ]. In a series of 1808 patients who received ARFI, those patients with an ARFI score > 1.33 cm/s showed a higher probability of HCC development than those with an ARFI score ≤ 1.33 cm/s[ 25 ].…”

Section: Discussionmentioning

confidence: 99%

Acoustic radiation force impulse predicts long-term outcomes in a large-scale cohort: High liver cancer, low comorbidity in hepatitis B virus

Tai¹,

Harrison²,

Chen³

et al. 2023

World J Gastroenterol

View full text Add to dashboard Cite

BACKGROUND Acoustic radiation force impulse (ARFI) is used to measure liver fibrosis and predict outcomes. The performance of elastography in assessment of fibrosis is poorer in hepatitis B virus (HBV) than in other etiologies of chronic liver disease. AIM To evaluate the performance of ARFI in long-term outcome prediction among different etiologies of chronic liver disease. METHODS Consecutive patients who received an ARFI study between 2011 and 2018 were enrolled. After excluding dual infection, alcoholism, autoimmune hepatitis, and others with incomplete data, this retrospective cohort were divided into hepatitis B (HBV, n = 1064), hepatitis C (HCV, n = 507), and non-HBV, non-HCV (NBNC, n = 391) groups. The indexed cases were linked to cancer registration (1987-2020) and national mortality databases. The differences in morbidity and mortality among the groups were analyzed. RESULTS At the enrollment, the HBV group showed more males (77.5%), a higher prevalence of pre-diagnosed hepatocellular carcinoma (HCC), and a lower prevalence of comorbidities than the other groups ( P < 0.001). The HCV group was older and had a lower platelet count and higher ARFI score than the other groups ( P < 0.001). The NBNC group showed a higher body mass index and platelet count, a higher prevalence of pre-diagnosed non-HCC cancers ( P < 0.001), especially breast cancer, and a lower prevalence of cirrhosis. Male gender, ARFI score, and HBV were independent predictors of HCC. The 5-year risk of HCC was 5.9% and 9.8% for those ARFI-graded with severe fibrosis and cirrhosis. ARFI alone had an area under the receiver operating characteristic curve (AUROC) of 0.742 for prediction of HCC in 5 years. AUROC increased to 0.828 after adding etiology, gender, age, and platelet score. No difference was found in mortality rate among the groups. CONCLUSION The HBV group showed a higher prevalence of HCC but lower comorbidity that made mortality similar among the groups. Those patients with ARFI-graded severe fibrosis or cirrhosis should receive regular surveillance.

show abstract

Prognostic value of liver stiffness measurement in patients with hepatocellular carcinoma (HCC) treated by radiofrequency ablation: a meta-analysis

Cited by 7 publications

References 27 publications

Influence of extracellular matrix composition on tumour cell behaviour in a biomimetic in vitro model for hepatocellular carcinoma

Influence of extracellular matrix composition on tumour cell behaviour in a biomimetic in vitro model for hepatocellular carcinoma

Construction of a nomogram for predicting compensated cirrhosis with Wilson’s disease based on non-invasive indicators

Acoustic radiation force impulse predicts long-term outcomes in a large-scale cohort: High liver cancer, low comorbidity in hepatitis B virus

Contact Info

Product

Resources

About