Prognostic value of monosomal karyotype in comparison to complex aberrant karyotype in acute myeloid leukemia: a study on 824 cases with aberrant karyotype

Abstract

In acute myeloid leukemia (AML) the subset with complex karyotype (CK) is traditionally regarded as the worst prognostic group. However, > 3, > 4, or

Monosomal Karyotypes among 1147 Chinese Patients with Acute Myeloid Leukemia: Prevalence, Features and Prognostic Impact

“…Initially, we determined the frequency and baseline character of MK in Chinese AML patients. In our study, the incidences of monosomy karyotype were 13% in patients age 15 to 60 years and 18% in patients between 15 and 88 years old, which were obviously lower than those reported by Breems et al (25.1% in patients age 15 to 60 years) (Breems et al, 2008), SWOG (28.5% in patients between 16 and 88 years old) (Medeiros et al, 2010), Kayser et al (2012) (30% in patients age 16 to 85 years), and other investigators (Grimwade et al, 2010;Haferlach et al, 2012). This discrepancy might be attributed to two main factors: (1) Compared with many currently published studies on MK, most of which were from large multicenter clinical trials, the present study was from large singlecenter.…”

Complex or monosomal karyotype and not blast percentage is associated with poor survival in acute myeloid leukemia and myelodysplastic syndrome patients with inv(3)(q21q26.2)/t(3;3)(q21;q26.2): a Bone Marrow Pathology Group study

“…Other karyotypic features such as a structurally complex or monosomal karyotype have been reported as a strong negative prognostic indicator in overall MDS and AML. 10,[25][26][27]36,37 We found that these were also independent indicators of poor prognosis inv(3)/t(3;3) MDS and AML. Interestingly, t(9;22) was noted in 2 inv(3)/t(3;3) AML patients as secondary clonal evolution or part of complex karyotype in a de novo AML patient without history of CML.…”

“…1,22 Monosomy 7, in particular, is reported in approximately 40-60% of inv(3)/t(3;3) AML patients and is associated with dismal prognosis. 2,6,22,37 In our series, -7/del(7q) abnormality (37.3%) was the most common additional abnormality and while this was a poor prognostic factor on univariable analysis, it did not retain statistical significance in the multivariable model. Other karyotypic features such as a structurally complex or monosomal karyotype have been reported as a strong negative prognostic indicator in overall MDS and AML.…”

Outcome of conditioning intensity in acute myeloid leukemia with monosomal karyotype in patients over 45 year‐old: A study from the acute leukemia working party (ALWP) of the European group of blood and marrow transplantation (EBMT)

“…This category is defined as the presence of two or more autosomal monosomies or one autosomal monosomy in combination with at least one structural chromosomal abnormality. This new risk category is associated with a very poor outcome with an estimated 4-year survival rate of 4% [7,8]. The benefit of SCT in this subpopulation has been studied in several retrospective studies and all of them seem to favor the performance of SCT in CR1 [9]2 [11].…”