Prognostic Value of Multifocal Electroretinography and Optical Coherence Tomography in Eyes Undergoing Panretinal Photocoagulation for Diabetic Retinopathy

Zhu, Ying; Zhang, Ting; Wang, Ke-yan; Xu, Gezhi

doi:10.1167/iovs.14-14704

Cited by 7 publications

(2 citation statements)

References 31 publications

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“…The disruption of Müller cells in diabetic macular edema has also been shown in multifocal electroretinogram studies as a decrease of the P1 amplitude in the central ring produced by bipolar and Müller cells. 28,29 In particular, Esfahani et al reported that a decrease in P1 amplitude is associated with DRILs, IRC, and EZ disruption and also with visual acuity. 30 Further study on the relationship between foveal Müller cell cone disruption and multifocal electroretinogram will provide physiological evidence that the foveal Müller cell cone structure is a predictive biomarker.…”

Section: Post Hoc Studies Of Protocol T Evaluated the Effectiveness O...mentioning

confidence: 99%

Foveal Müller Cell Cone as a Prognostic Optical Coherence Tomography Biomarker for Initial Response to Antivascular Endothelial Growth Factor Treatment in Cystoid Diabetic Macular Edema

Choi

Yun

et al. 2022

Retina

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Purpose: To investigate the effect of the foveal Müller cell cone structure on the anatomical and functional response to intravitreal bevacizumab treatment in patients with diabetic macular edema. Methods: In 93 treatment-naive eyes with center-involved cystic type diabetic macular edema, spectral-domain optical coherence tomography scans of baseline were retrospectively evaluated to determine the foveal Müller cell cone structure and prognostic features including length of disorganization in the retinal inner layers and ellipsoid zone disruption. The area and circularity of the foveal avascular zone of the superficial and deep capillary plexus 1 month after intravitreal bevacizumab treatment were evaluated using optical coherence tomography angiography. Results: Destruction of the foveal Müller cell cone structure and a large foveal avascular zone in the deep capillary plexus (mm2) correlated strongly with a poor anatomical response (CST > 250 µm) at 1 month after first intravitreal bevacizumab (Exp [B] = 29.444, P = 0.002 and Exp [B] = 12.419, P = 0.013, respectively). A destroyed Müller cell cone structure (P = 0.008) and length of ellipsoid zone disruption (P < 0.001) at baseline were associated with poor visual acuity at 1 month after the first intravitreal bevacizumab. Conclusion: The foveal Müller cell cone structure correlates with the response to initial antivascular endothelial growth factor treatment.

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Section: Post Hoc Studies Of Protocol T Evaluated the Effectiveness O...mentioning

confidence: 99%

Foveal Müller Cell Cone as a Prognostic Optical Coherence Tomography Biomarker for Initial Response to Antivascular Endothelial Growth Factor Treatment in Cystoid Diabetic Macular Edema

Choi

Yun

et al. 2022

Retina

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“…Evaluation of higher order kernels and other approaches such as oscillatory potentials or slow double-stimulation mfERG have been used to examine the level of impairment in retinal diseases (e.g., mfERG results suggest that the inner retina is first affected in diabetic retinopathy). Alterations in mfERG might even be measurable in diabetic patients before structural changes of diabetic retinopathy occur, suggesting an opportunity to predict the disease progression (Bearse et al, 2006;Bearse & Ozawa, 2014;Han et al, 2004;Harrison et al, 2011;Kim, Song, & Yu, 2007;Laron et al, 2012;Ng, Bearse, Schneck, Barez, & Adams, 2008;Onozu & Yamamoto, 2003;Xu, Hu, Huang, Huang, & Chen, 2006;Zhu, Zhang, Wang, & Xu, 2014).…”

Section: Clinical Applicationmentioning

confidence: 99%

M-sequences in ophthalmic electrophysiology

Müller

Meigen

2016

Journal of Vision

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The aim of this review is to use the multimedia aspects of a purely digital online publication to explain and illustrate the highly capable technique of m-sequences in multifocal ophthalmic electrophysiology. M-sequences have been successfully applied in clinical routines during the past 20 years. However, the underlying mathematical rationale is often daunting. These mathematical properties of m-sequences allow one not only to separate the responses from different fields but also to analyze adaptational effects and impacts of former events. By explaining the history, the formation, and the different aspects of application, a better comprehension of the technique is intended. With this review we aim to clarify the opportunities of m-sequences in order to motivate scientists to use m-sequences in their future research.

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Prediction of regression of retinal neovascularisation after panretinal photocoagulation for proliferative diabetic retinopathy

Chatziralli

Sergentanis

Sivaprasad

2016

Graefes Arch Clin Exp Ophthalmol

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Prognostic Value of Multifocal Electroretinography and Optical Coherence Tomography in Eyes Undergoing Panretinal Photocoagulation for Diabetic Retinopathy

Abstract: A lower amplitude of mfERG and disrupted foveal ellipsoid zone status were significantly correlated with a worse visual prognosis in diabetic eyes after PRP.

Cited by 7 publications

References 31 publications

Foveal Müller Cell Cone as a Prognostic Optical Coherence Tomography Biomarker for Initial Response to Antivascular Endothelial Growth Factor Treatment in Cystoid Diabetic Macular Edema

Foveal Müller Cell Cone as a Prognostic Optical Coherence Tomography Biomarker for Initial Response to Antivascular Endothelial Growth Factor Treatment in Cystoid Diabetic Macular Edema

M-sequences in ophthalmic electrophysiology

Prediction of regression of retinal neovascularisation after panretinal photocoagulation for proliferative diabetic retinopathy

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