Prognostic value of peripheral blood inflammatory cell subsets in patients with acute coronary syndrome undergoing percutaneous coronary intervention

Abstract

Objective This study aimed to investigate the predictive value of inflammatory cells in peripheral blood on the prognosis of patients with acute coronary syndrome (ACS) undergoing percutaneous coronary intervention (PCI). Methods Patients (n=1558) were consecutively enrolled and the median follow-up was 1142 days. Patients were divided into the major adverse cardiac events (MACE) 1 group (n=63) (all-cause mortality [n=58] and rehospitalization for severe heart failure [n=5], no MACE1 group (n=1495), MACE2 group (n=38) (cardiac mortality [n=33] and rehospitalization for severe heart failure [n=5]), and no MACE2 group (n=1520). The neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), and platelet-to-lymphocyte ratio (PLR) were analyzed. Results The NLR, MLR, and PLR were higher in the MACE groups than in the no MACE groups. Different subsets of inflammatory cells had similar diagnostic values for MACE. Kaplan–Meier curves showed that the survival time gradually decreased with an increase in the degree of risk as determined by the NLR, MLR, and PLR. The risk of MACE was highest in the extremely high-risk group. Conclusion Peripheral blood inflammatory cell subsets can predict MACE in patients with ACS undergoing PCI. These cell subsets could be important laboratory markers for the prognosis and clinical treatment of these patients.

Prognostic Impact of Multiple Lymphocyte-Based Inflammatory Indices in Acute Coronary Syndrome Patients

“…The counts of lymphocyte, platelet, neutrophil, and monocyte were measured in the Central Laboratory of Beijing Anzhen Hospital. In this study, the lymphocyte-based inflammatory indices included: PLR (platelet/ lymphocyte), NLR (neutrophil/ lymphocyte), MLR (monocyte/ lymphocyte), SII (platelet * neutrophil/ lymphocyte), and SIRI (neutrophil * monocyte/ lymphocyte) ( 15 , 18 ). The GRACE risk score was analyzed as a numerical value and calculated according to the GRACE risk model by using a computer program ( http://www.outcomes-umassmed.org/grace ).…”

The Prognostic Value of Hematologic Inflammatory Markers in Patients With Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention

“…Previously, we described the SII, dNLR, NLR, PLR, and MLR as suitable laboratory markers for identifying high-risk ACS patients after PCI. 10 , 11 In recent years, new systemic inflammation markers, such as AISI, SIRI, and NLPR, have attracted the attention of many researchers because they include multiple components of CBC and are also easy to obtain. Monocytes and neutrophils are part of the innate immune system and produce pro-inflammatory mediators.…”

“… 9 Recently published studies have demonstrated that many combined ratios of CBC parameters, such as systemic immune-inflammatory index (SII), derived neutrophil-to-lymphocyte ratio (dNLR), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and monocyte-to-lymphocyte ratio (MLR), could be useful prognostic markers in ACS patients undergoing PCI. 10 , 11 Furthermore, as more complicated and newly mentioned inflammatory markers, the aggregate index of systemic inflammation (AISI), systemic inflammation response index (SIRI), and neutrophil-to-lymphocyte*platelet ratio (NLRP) have only been proposed simultaneously as biomarkers for predicting mortality in COVID-19 patients. 9 , 12 , 13 However, no studies have investigated the prognostic capacity of these 3 novel indices for ACS prognosis.…”

Nghiên Cứu Đặc Điểm Đa Hình Gen Cyp2c19 Và Giá Trị Của Tỉ Số Tế Bào Viêm Trong Khả Năng Tiên Lượng Biến Cố Tim Mạch Ở Bệnh Nhân Hội Chứng Vành Cấp

“…Điểm cắt tối ưu của NLR, MPVLR lần lượt là 3,02 và 2,91 (độ nhạy và độ đặc hiệu như bảng 3), AUC>0,7 và có ý nghĩa thống kê (p<0,05). Các nghiên cứu khác của các tác giả Dong-Hyun Choi và cộng sự (2018) [7], Ahmed Mohammed Shumilah (2021) [8], Xiuxin Gao (2021) [9], Xue-Ting Li (2020) [10], Willim H. (2021) [11] cũng đã ghi nhận các tỉ số này có giá trị tiên lượng độc lập cho biến cố tim mạch ở HCVC.…”