Prognostic value of pre-treatment 18F-FDG PET uptake for nasopharyngeal carcinoma

Abstract

F-FDG PET/CT uptake before treatment, as determined by SUV, may be a valuable tool to evaluate prognosis in NPC patients.

Baseline Suvmax Correlates with Tumor Hypoxia and Patient Outcomes in Nasopharyngeal Carcinoma: Employing Transcriptomic Gene Signature Analysis

“…T stage, indicative of the biological aggressiveness of tumors, further supported the association between Suvmax and the biological aggressiveness of NPC. Previous studies have also indicated the clinical prognostic value of Suvmax in NPC [7,24] . For instance, in a study involving 253 patients with newly diagnosed metastatic NPC, those with higher Suvmax exhibited lower 3-year Overall Survival (OS) [7] .…”

“…The ability of Suvmax to predict distant metastasis remains a topic of debate. While Meryem Aktan et al identi ed Suvmax as an important prognostic factor for distant metastasis and its utility in evaluating Disease Free Survival (DFS) results [24] , Kazuhiro Kitajima et al found no signi cant correlation between primary tumor Suvmax and Distant Metastasis Free Survival (DMFS) [25] . Our study aligns with the latter, indicating that Suvmax may predict prognosis more through local treatment failure than distant metastasis.…”

Prognostic value of baseline [18F]-fluorodeoxyglucose positron emission tomography parameters MTV, TLG and asphericity in an international multicenter cohort of nasopharyngeal carcinoma patients

“…Treatment details of Canadian patients can be found in the supplementary files of the original publication [16]. All patients received intensity modulated radiotherapy (IMRT) or volumetric arc modulated radiotherapy (VMAT) with a total dose of 70 Gray (Gy) in 35 Patients from Berlin received VMAT with a total dose of 57.5 to 76.6 Gy. Most patients were treated with a simultaneous integrated boost (SIB) delivering single fractions of 2.2 Gy, some patients received hyperfractionated radiotherapy with twice daily 1.4 Gy.…”

“…A recent publication investigated the prognostic impact of FDG-PET in a monocentric study with 49 Italian patients and found TLG and SUV max to be significantly associated with OS of patients [34]. Another monocentric study on 52 Turkish patients found SUV max of the primary tumor to be significantly associated with FFDM and disease-free survival, but not with OS [35]. Furthermore, another monocentric study from Turkey investigated the role of primary tumor and lymph node SUV max on the outcome of 32 patients.…”