Prognostic value of pretreatment anemia in patients with soft tissue sarcoma

Shi, Landa; Wang, Yuqiang; Li, Long‐Qing; Chou, Dean; Zhao, Yao; Zhang, Shuhao; Wang, Limin; Zhang, Min; Liu, Yilin

doi:10.1097/md.0000000000027221

Cited by 10 publications

(5 citation statements)

References 41 publications

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“…Pretreatment anemia has already been identified as a poor prognostic marker in ST sarcoma, associated with poorer overall-and disease-free survival. 26,27 However, most studies focus on its role…”

Section: Discussionmentioning

confidence: 99%

“…A Preoperative hematocrit <30% was an important risk factor for ST complications after pelvic sarcoma (OR = 1.84, p = 0.042). Pretreatment anemia has already been identified as a poor prognostic marker in ST sarcoma, associated with poorer overall‐ and disease‐free survival 26,27 . However, most studies focus on its role in long‐term outcomes, and to date, there are no studies assessing the impact of this variable after sarcoma resection in the pelvis.…”

Section: Discussionmentioning

confidence: 99%

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Risk factors for 30‐day soft tissue complications after pelvic sarcoma surgery: A National Surgical Quality Improvement Program study

Gonzalez

Karczewski

Bedi

et al. 2023

Journal of Surgical Oncology

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Introduction Soft tissue (ST) complications after resection of bone and ST sarcomas of the pelvis occur more frequently than in appendicular tumors. We sought to identify risk factors for complications within 30 days of surgery. Methods The National Surgical Quality Improvement Program database was used for this study. Patients with sarcomas of bone and ST of the pelvis were retrieved using Current Procedural Terminology and International Classification of Diseases codes. Outcomes assessed were ST complications, overall complication rates, 30‐day reoperation, and mortality. Results A total of 770 patients with pelvic bone and ST sarcoma were included. The ST complication rate was 12.6%, including 4.9% superficial and 4.7% deep surgical site infections. Higher ST complication rates were seen in patients >30 years, with partially dependent health status, hematocrit <30%, bone tumors, tumor >5 cm, amputation procedures, and longer operative times. ST complication rates were 1.5 and 3 times higher in pelvic sarcoma surgeries than in the lower and upper extremities, respectively. Age >30 years (odds ratio [OR] = 5.07), hematocrit <30% (OR = 1.84), operative time 1–3 h (OR = 2.97), and >3 h (OR = 4.89) were risk factors for ST complications. Conclusion One in nine patients with pelvic sarcoma surgery will develop ST complications within 30 days. Risk factors for ST complications were age >30, hematocrit <30%, and longer operative time.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Risk factors for 30‐day soft tissue complications after pelvic sarcoma surgery: A National Surgical Quality Improvement Program study

Gonzalez

Karczewski

Bedi

et al. 2023

Journal of Surgical Oncology

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“…3 The presence of anemia has significant associations with increased morbidity, all-cause hospitalizations, and all-cause mortality in adults. 4 Serious adverse effects associated with anemia are observed in patients with heart failure with preserved ejection fraction, 5,6 and the presence of anemia status is a valuable prognostic indicator in several serious diseases, including soft tissue sarcomas 7 and heart failure. 6 Some older data suggest that the prevalence of anemia is rising in the general population of the United States.…”

Section: Introductionmentioning

confidence: 99%

Anemia prevalence time trends and disparities in the US population: examination of NHANES 1999–2020

Hwang

Ahuja

Haque

et al. 2023

Journal of Investigative Medicine

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While a rising prevalence of anemia in the United States was reported in older studies, recent data are lacking. To estimate the prevalence and time trends of anemia in the United States and to examine how these estimates differ by gender, age, race, and household income to poverty threshold ratio (HIPR), we used the National Health and Nutrition Examination Surveys from 1999 to 2020. The presence of anemia was determined using the World Health Organization criteria. Survey-weighted raw and adjusted prevalence ratios (PRs) were determined using generalized linear models for the overall population and by gender, age, race, and HIPR. In addition, an interaction between gender and race was explored. Complete data on anemia, age, gender, and race were available on 87,554 participants (mean age = 34.6 years, women = 49.8%, Whites = 37.3%). Anemia prevalence increased from 4.03% during the 1999–2000 survey cycle to 6.49% during 2017–2020. In adjusted analyses, anemia prevalence was higher in >65 than in 26–45 years old (PR = 2.14, 95% confidence interval (CI) = 1.95, 2.35), in Blacks than Whites (PR = 3.97, 95% CI = 3.63, 4.35), in women than men (PR = 1.98, 95% CI = 1.83, 2.13), and in those with HIPR ≤ 1 than >4 (PR = 0.68, 95% CI = 0.61, 0.75). Gender modified the relationship between anemia and race; when compared to their male counterparts, Black, Hispanic, and other women had higher anemia prevalence than White women (all interaction p values <0.05). The anemia prevalence in the United States has risen from 1999 to 2020 and remains high among the elderly, minorities, and women. The difference in anemia prevalence between men and women is larger in non-Whites.

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“…The low level of Hb, in general, is indicative of a subclinical anemia status that has been frequently reported as a poor prognosis biomarker for mSTS as well as in other tumor types ( Szkandera et al, 2014 ; Shi et al, 2021 ). It has been suggested that an inflammatory process, likely induced by tumor itself, can lead to the development of a chronic anemic status ( Natalucci et al, 2021 ).…”

Section: Discussionmentioning

confidence: 99%