Prognostic Value of Proinflammatory Markers in Patients After Kidney Transplantation in Relation to the Presence of Diabetes

Cieniawski, Dominik; Miarka, Przemysław; Ignacak, Ewa; Bȩtkowska-Prokop, Alina; Waluś-Miarka, Małgorzata; Idzior−Waluś, Barbara; Kuźniewski, Marek; Sułowicz, Władysław

doi:10.1016/j.transproceed.2016.03.008

Cited by 9 publications

(6 citation statements)

References 17 publications

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“…Cieniawski et al . found no association between proinflammatory markers and development of PTDM in the late phase after kidney transplantation; however, both IL‐6 and TNF receptor II were associated with increased mortality or rejection. The prognostic performance of these biomarkers is of great interest and should be investigated in forthcoming studies.…”

Section: Discussionmentioning

confidence: 88%

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Inflammatory and related biomarkers are associated with post-transplant diabetes mellitus in kidney recipients: a retrospective study

et al. 2018

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In this study, we investigate the association between selected inflammatory-related biomarkers and post-transplant hyperglycemia in kidney transplant recipients. This retrospective analysis comprises 852 patients receiving a kidney transplant at the Norwegian national transplant center between 2007 and 2012, all having a normal oral glucose tolerance test (OGTT) before transplantation. A diagnostic OGTT was performed 10 weeks post-transplant to examine the association between inflammation-related biomarkers and two-hour plasma glucose (2HPG) by multivariable linear regression models adjusting for BMI, age, graft function, fasting insulin levels, dosage of prednisolone, and concentration of calcineurin inhibitors. Six of 20 biomarkers were significantly associated with 2HPG in multivariate analyses showing strong associations with soluble tumor necrosis factor type 1 (P = 0.027), Pentraxin 3 (P = 0.019), macrophage migration inhibitory factor (P = 0.024), and endothelial protein C receptor (P = 0.001). These associated markers reflect several distinct but also overlapping pathways including activation of tumor necrosis factor, macrophages, and endothelial cells. The multinomial logistic regression model showed a clear association between the inflammatory biomarkers and post-transplant diabetes mellitus (PTDM). The association between a range of inflammation markers and PTDM suggests that these markers may be target for future studies on pathogenesis and perhaps also treatment of PTDM.

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Section: Discussionmentioning

confidence: 88%

“…In a recent publication, Cieniawski et al . found increased levels of high sensitivity interleukin (IL)‐6 in patients with PTDM. In addition, high levels of IL‐6 and TNF receptor II were associated with increased risk of graft loss and death.…”

Section: Introductionmentioning

confidence: 99%

Inflammatory and related biomarkers are associated with post-transplant diabetes mellitus in kidney recipients: a retrospective study

et al. 2018

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“…Several studies have dealt with the genetic analysis of polymorphisms in IL-10 genes. The authors of Naz et al confi rmed that the polymorphism in the IL-10 gene (rs1800896) was associated with DM type II (18). Recently, a cross-sectional study of the Ethiopian population comparing patients with DM type II with healthy controls was published.…”

Section: Discussionmentioning

confidence: 99%

Hyperleptinemia as a risk factor for post-transplant diabetes mellitus development after kidney transplantation

GRANAK¹,

Vnučák²,

Beliančinová³

et al. 2022

BLL

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INTRODUCTION: Adipose tissue is involved in the synthesis of hormones that have an impact on food intake regulation, control of insulin sensitivity or regulation of infl ammatory processes. The aim of this study was to determine the importance of adipocytokines and interleukins levels for the development of post-transplant diabetes mellitus (PTDM) after kidney transplantation (KT). MATERIAL AND METHODS: In the prospective analysis, the studied sample (n = 104) was divided into the control group, prediabetes group and PTDM group. Prior to transplantation, and subsequently, at 3, 6 and 12 months after KT, we recorded the basic characteristics of the donor and recipient, including parameters refl ecting graft function, metabolic and anthropometric parameters. At the same time, we monitored the levels of adiponectin, leptin and interleukins during the monitored period. RESULTS: Using multivariate logistic regression, we identifi ed hyperleptinemia 12 months after KT as an independent risk factor for PTDM development 1 year after KT [OR 1.0320; 95% Cl 0.9785-1.0884 (p=0.0038)]. At the same time, we confi rmed that age at the time of KT is also an independent risk factor for PTDM [OR 1.0903; 95% Cl 1.0149-1.1714 (p = 0.0180)]. CONCLUSION: We confi rmed that elevated leptin level 12 months after KT is associated with the development of PTDM (Tab.

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“…Others suggest the involvement of tumor necrosis factor (TNF). Elevated levels of high sensitivity interleukin IL-6 were observed in PTDM patients by the team of Cieniawski and colleagues [ 118 ]. In turn, Heldal et al [ 116 ] demonstrated a strong relationship between four inflammation-related parameters (sTNFR1, EPCR, PTX3, and MIF) and plasma glucose levels 2 h after an OGTT in patients, 10 weeks after kidney transplantation.…”

Section: Possible Biomarkers In Ptdmmentioning

confidence: 99%

Diabetes and Cardiovascular Risk in Renal Transplant Patients

Rysz

Franczyk

Radek

et al. 2021

IJMS

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End-stage kidney disease (ESKD) is a main public health problem, the prevalence of which is continuously increasing worldwide. Due to adverse effects of renal replacement therapies, kidney transplantation seems to be the optimal form of therapy with significantly improved survival, quality of life and diminished overall costs compared with dialysis. However, post-transplant patients frequently suffer from post-transplant diabetes mellitus (PTDM) which an important risk factor for cardiovascular and cardiovascular-related deaths after transplantation. The management of post-transplant diabetes resembles that of diabetes in the general population as it is based on strict glycemic control as well as screening and treatment of common complications. Lifestyle interventions accompanied by the tailoring of immunosuppressive regimen may be of key importance to mitigate PTDM-associated complications in kidney transplant patients. More transplant-specific approach can include the exchange of tacrolimus with an alternative immunosuppressant (cyclosporine or mammalian target of rapamycin (mTOR) inhibitor), the decrease or cessation of corticosteroid therapy and caution in the prescribing of diuretics since they are independently connected with post-transplant diabetes. Early identification of high-risk patients for cardiovascular diseases enables timely introduction of appropriate therapeutic strategy and results in higher survival rates for patients with a transplanted kidney.

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Prognostic Value of Proinflammatory Markers in Patients After Kidney Transplantation in Relation to the Presence of Diabetes

Cited by 9 publications

References 17 publications

Inflammatory and related biomarkers are associated with post-transplant diabetes mellitus in kidney recipients: a retrospective study

Inflammatory and related biomarkers are associated with post-transplant diabetes mellitus in kidney recipients: a retrospective study

Hyperleptinemia as a risk factor for post-transplant diabetes mellitus development after kidney transplantation

Diabetes and Cardiovascular Risk in Renal Transplant Patients

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