Prognostic value of Red Blood Cell Distribution Width in Acute Kidney Injury Patients: A Systematic Review and Meta-analysis

Liu, Zhengsheng; Wang, Shanshan; Yao, Xiongbo; Xing, Jinchun

doi:10.1101/750190

Cited by 3 publications

(5 citation statements)

References 45 publications

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“…This study found that RDW > 15.45 best predicts death with 81.5% sensitivity and 60.3% specificity (Table 7), was statistically significant (p 0.001). In a study done in 2019, it was found that RDW is a predictive for AKI, specifically, contrast induced AKI and cardiac surgery associated AKI (14). In our study RDW produced ROC curves, RDW's AUC was 0.788 (P 0.001) (Fig 1).…”

Section: Discussionsupporting

confidence: 56%

Prognostic value of Red Blood Cells Distribution Width in Acute Kidney Injury in PICU

Afify

Abdelhamid

abdellateef

et al. 2023

Benha Medical Journal

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Background: RDW predicts short-term outcome in critically ill AKI patients. RDW's long-term all-cause mortality prognostic value in children is unknown. Methods: one hundred PICU patients were studied. Clinical Pathology Department undertook laboratory tests. Scoring system used in this study are SOFA score which is a straightforward and objective measure to calculate organ dysfunction in six organ systems, APSIII score, RIFLE score and KDIGO classification. Results: RDW > 15.45 had 81.5% sensitivity and 60.3% specificity for predicting mortality. Statistically significant (p 0.001) Septic shock, high GCS, high SOFA score, high APS III, high initial blood creatinine, and high initial RDW are death risk factors. The higher initial serum creatinine wasn't an independent risk factor in multivariate regression analysis. RDW, KDIGO and RIFLE criteria had no correlation. Conclusion: Higher RDW was associated with increased mortality in critically ill AKI patients. Large prospective trials with longer follow-Up must corroborate our findings.

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Section: Discussionsupporting

confidence: 56%

Prognostic value of Red Blood Cells Distribution Width in Acute Kidney Injury in PICU

Afify

Abdelhamid

abdellateef

et al. 2023

Benha Medical Journal

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“…1 . Finally, 16 cohort studies 17 18 19 20 21 22 23 24 25 26 34 35 36 37 38 39 were available for the meta-analysis.…”

Section: Resultsmentioning

confidence: 99%

“…As shown in Table 1 , 16 cohort studies were included in the meta-analysis. Six of them were prospective cohort studies 17 19 21 34 36 39 and the remaining were retrospective cohort studies 18 20 22 23 24 25 26 35 37 38 . These studies were performed in Austria 17 18 20 , Greece 21 , Brazil 19 , the United States 35 36 , Iran 34 , and China 22 23 24 25 26 37 38 39 , and all included critically ill patients who were admitted to the ICU, such as patients with sepsis, pulmonary embolism, acute myocardial infarction, severe acute pancreatitis, respiratory failure, intracerebral hemorrhage, and severe multiple trauma etc.. Serum Hcy was measured within 48 hours of ICU admission, and the follow-up durations varied from 2 weeks to 12 months.…”

Section: Resultsmentioning

confidence: 99%

“…Overall, 375 patients died during follow-up. Difference of serum Hcy at ICU admission between survivors and non-survivors was reported in 13 studies 17 18 19 20 21 24 25 26 34 35 36 37 39 with 985 patients, while the association between HHcy and all-cause mortality of the critically ill patients was reported in 7 studies 22 23 24 25 26 37 38 with 1013 patients. For the latter studies, HHcy was all defined as serum Hcy>15 μmol/l, and the association between HHcy and all-cause mortality was analyzed with multivariate models incorporating age, sex, and other parameters of disease severity.…”

Section: Resultsmentioning

confidence: 99%

“…Seven retrospective cohort studies 22 23 24 25 26 37 38 with 1013 patients, all from China, evaluated the association between HHcy and all-cause mortality of the critically ill patients. Pooled results showed that HHcy at ICU admission was independently associated with a higher risk of all-cause mortality (OR: 2.99, 95% CI: 2.26 to 3.97, p<0.001; I 2 =69%; Fig.…”

Section: Resultsmentioning

confidence: 99%

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Homocysteine and the Mortality of Critically Ill Patients: A Meta-Analysis

Yuan

Zheng

2022

Horm Metab Res

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Prevalence of hyperhomocysteinemia (HHcy) is high in critically ill patients. However, the association between serum homocysteine level and outcomes of the critically ill patients remains unknown. We performed a meta-analysis of cohort studies to comprehensively evaluate the above association. Relevant cohort studies were identified by search of electronic databases including PubMed, Embase, Web of Science, Wanfang, and CNKI from the inception of the databases to February 5, 2022. A randomized-effect model incorporating the possible between-study heterogeneity was used to pool the results. Overall, 16 cohorts with 1663 critically ill patients who were admitted to the intensive care unit (ICU) were involved in the meta-analysis. Pooled results showed that compared to non-survivors of the critical illnesses, survivors had significantly lower serum level of Hcy at ICU admission [mean difference (MD): –3.42 μmol/l, 95% confidence interval (CI): –5.89 to 0.94, p=0.007; I2=86%]. Subgroup analysis showed that the difference of Hcy between survivors and non-survivors was significant in Asian patients (MD: –8.17 μmol/l, p<0.001), but not in non-Asians (MD: 0.30 μmol/l, p=0.62; p for subgroup difference<0.001). Moreover, meta-analysis with seven cohorts, all including Chinese patients, showed that HHcy at ICU admission was independently associated with a higher risk of all-cause mortality in critically ill patients (odds ratio: 2.99, 95% CI: 2.26 to 3.97, p<0.001; I2=69%). A higher serum level of Hcy at ICU admission may be associated with an increased risk of all-cause mortality in critically ill patients, particularly in the Chinese population.

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Red blood cell distribution width as a predictor of mortality among patients regularly visiting the nephrology outpatient clinic

Yoo

Park

et al. 2021

Sci Rep

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The association between increased red blood cell distribution width (RDW) and mortality among patients treated on an outpatient basis in the nephrology outpatient clinic is unclear. Therefore, our study aimed to investigate the association between baseline and time-averaged RDW and mortality risk in patients treated in our nephrology outpatient clinic. Our multi-center retrospective analysis was based on data of 16,417 outpatient nephrology patients with available baseline renal function and RWD values. The median baseline RDW was 13.0% (range, 10.0–32.1%). The high-RDW group was defined as the top quartile (≥ 13.8%, n = 4302). The crude mortality rate was 15.0% (n = 1806) at a median follow-up of 127.5 months. From the results of the multivariate Cox proportional hazards regression model adjusted for covariates, including eGFR, hemoglobin, and factors of anemia treatment, patients with a high time-averaged RDW had increased mortality risk (adjusted hazard ratio, 1.505; 95% confidence interval, 1.326–1.708; P < 0.001), irrespective of sex, presence of anemia, and chronic kidney disease, except in individuals aged < 45 years. Thus, increased baseline and time-averaged RDW were significantly associated with increased mortality in patients aged > 45 years treated on an outpatient basis in the nephrology clinic.

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Prognostic value of Red Blood Cell Distribution Width in Acute Kidney Injury Patients: A Systematic Review and Meta-analysis

Cited by 3 publications

References 45 publications

Prognostic value of Red Blood Cells Distribution Width in Acute Kidney Injury in PICU

Prognostic value of Red Blood Cells Distribution Width in Acute Kidney Injury in PICU

Homocysteine and the Mortality of Critically Ill Patients: A Meta-Analysis

Red blood cell distribution width as a predictor of mortality among patients regularly visiting the nephrology outpatient clinic

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