Purpose An ongoing outbreak of coronavirus disease 2019 (COVID-19) emerged in Wuhan since December 2019 and spread globally. However, information about critically ill patients with COVID-19 is still limited. We aimed to describe the clinical characteristics and outcomes of critically ill patients with COVID-19 and figure out the risk factors of mortality. Methods We extracted data retrospectively regarding 733 critically ill adult patients with laboratory-confirmed COVID-19 from 19 hospitals in China through January 1 to February 29, 2020. Demographic data, symptoms, laboratory values, comorbidities, treatments, and clinical outcomes were collected. The primary outcome was 28-day mortality. Data were compared between survivors and non-survivors. Results Of the 733 patients included in the study, the median (IQR) age was 65 (56–73) years and 256 (34.9%) were female. Among these patients, the median (IQR) APACHE II score was 10 (7 to 14) and 28-day mortality was 53.8%. Respiratory failure was the most common organ failure (597 [81.5%]), followed by shock (20%), thrombocytopenia (18.8%), central nervous system (8.6%) and renal dysfunction (8%). Multivariate Cox regression analysis showed that older age, malignancies, high APACHE II score, high d -dimer level, low PaO 2 /FiO 2 level, high creatinine level, high hscTnI level and low albumin level were independent risk factors of 28-day mortality in critically ill patients with COVID-19. Conclusion In this case series of critically ill patients with COVID-19 who were admitted into the ICU, more than half patients died at day 28. The higher percentage of organ failure in these patients indicated a significant demand for critical care resources. Electronic supplementary material The online version of this article (10.1007/s00134-020-06211-2) contains supplementary material, which is available to authorized users.

A controllable and reproducible bipolar memristive protein nanodevice is fabricated by chemical immobilization of ferritin molecules within on‐wire lithography‐generated nanogaps. Control experiments suggest that programmable resistive switching is due to the electrochemical processes in the active centre of ferritin. Such ferritin‐based nanodevices with reversible resistance can be used for nonvolatile memory based on write‐read‐erase cycles.

Surface energy plays an important role in surface physics, [1,2] biophysics, [3,4] surface chemistry, [5,6] and catalysis. [7] A gradient of surface energy between a solid and liquid interface can induce transport of liquids [8][9][10][11] and water running uphill, [12] which is important for DNA analysis devices.[13] Due to the 2D nature and relatively few molecules or atoms involved, the density of surface energy is usually quite small, which is impractical for utilizing surface energy as an energy source. Nevertheless it is attractive to use surface energy at the nanoscale because of the lower power consumption for nanodevices and the higher specific surface area for nanomaterials. [14][15][16][17][18] In this work, we demonstrate an effective design of single-walled carbon nanotubes (SWNTs) to harvest surface energy of ethanol and convert it into electricity. In this ethanol-burner-like design, an open-circuit voltage (V oc ) can be obtained as a result of ethanol flow in the capillary channels formed among SWNTs driven by surface tension. The V oc remains constant as long as there is ethanol from the source. The maximum power can be up to $1770 pW per device and can serve as a self-powered system to drive a thermistor. Meanwhile, the performance (the inducing rate of V oc , the value of V oc , and the output power) can be significantly enhanced by the Marangoni effect. [19] SWNTs were synthesized by floating catalytic chemical vapor deposition and treated by diamond wire drawing dies, [20][21][22] which results in well-aligned individual SWNTs (see Supporting Information S1). The resulting SWNT rope ($25.0 mm (length) Â 0.6 mm (diameter), Fig. 1a) is connected to electrodes of aluminum film, forming a suspended structure on a glass slide. The device is measured by a Keithley 4200-SCS, semiconductor characterization system, (voltage resolution 1 mV) and the dynamic characteristics of the open-circuit voltage (V oc ) are monitored while adding ethanol (MOS grade, 99.9%) to the beaker (Fig. 1b, see Supporting Information S2).In an open beaker, no obvious V oc is observed at the beginning (angle 408, Fig. 2a). When the ethanol level reaches the SWNT rope, the V oc begins to increase. The increase of V oc is almost linear from zero to 200 mV for the first 240 s, then the V oc saturates gradually at 219 mV where is remains constant over 6 h as shown in Figure 2a. V oc can remain constant as long as the ethanol level is contacting the SWNT rope. When the beaker is covered as indicated by region 2 (Fig. 2b), V oc will gradually decrease back to the original value. This process can be repeated COMMUNICATION www.MaterialsViews.com www.advmat.de Figure 1. The SWNT device and schematic layout of the experimental setup. a) An image of the device with a suspended SWNT rope. After treating with diamond wire drawing dies, the SWNT rope has a diameter of $0.6 mm and length of $25.0 mm and is connected to the electrodes. b) When measuring, the device is placed into a beaker with an angle between the SWNT rope and the ethanol ...

A simple method to fabricate a visible light‐detectable hybrid nanodevice based on TiO2 nanoparticles and pristine graphene, ideally combining the advantages of both, is demonstrated. High photosensitivity of the hybrid device under visible and UV light irradiation paves the way for its application as a broad wavelength photodetector.