Prognostic value of <scp>lncRNA HOXA‐AS3</scp> in cervical cancer by targeting <scp>miR</scp>‐29a‐3p and its regulatory effect on tumor progression

Xu, Hui; Tang, Yan; He, Chuanyong; Tian, Yifei; Ni, Rong

doi:10.1111/jog.15360

Cited by 7 publications

(4 citation statements)

References 33 publications

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“…It is known that lncRNA HOXA-AS3 downregulation inhibited the cell invasion and migration in cervical cancer cells via targeting miR-29a-3p 32 . LncRNA HOXA-AS3 downregulation reduced migration and invasion via targeting miR-29a-3p in gastric cancer 33 .…”

Section: Resultsmentioning

confidence: 99%

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LncRNA HOXA-AS3 promotes cell proliferation and invasion via targeting miR-218-5p/FOXP1 axis in osteosarcoma

Li,

Chen,

Zhou

et al. 2024

Sci Rep

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Osteosarcoma is an aggressive form of bone cancer and affects the health in children and adolescents. Although conventional treatment improves the osteosarcoma survival, some patients have metastasis and drug resistance, leading to a worse prognosis. Therefore, it is necessary to explore the molecular mechanism of osteosarcoma occurrence and progression, which could discover the novel treatment for osteosarcoma. Long noncoding RNAs (lncRNAs) have been reported to regulate osteosarcoma occurrence and malignant progression. LncRNA HOXA-AS3 facilitates the tumorigenesis and progression in a variety of human cancers. However, the underlying mechanism of lncRNA HOXA-AS3-induced oncogenesis is poorly determined in osteosarcoma. To address this point, we utilized several cellular biological strategies and molecular approaches to explore the biological functions and mechanisms of lncRNA HOXA-AS3 in osteosarcoma cells. We found that lncRNA HOXA-AS3 facilitates cell proliferation and invasion via targeting miR-218-5p/FOXP1 axis in osteosarcoma. In conclusion, lncRNA HOXA-AS3 could be a promising target for osteosarcoma treatment.

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Section: Resultsmentioning

confidence: 99%

“…Moreover, lncRNA HOXA-AS3 regulated the miR-29a-3p and modulated tumor progression in cervical cancer. LncRNA HOXA-AS3 expression displayed a prognostic value in cervical cancer patients 32 . Furthermore, lncRNA HOXA-AS3 increased cell proliferation via modulation of miR-218-5p expression in oral squamous cell carcinoma 50 .…”

Section: Discussionmentioning

confidence: 98%

LncRNA HOXA-AS3 promotes cell proliferation and invasion via targeting miR-218-5p/FOXP1 axis in osteosarcoma

Li,

Chen,

Zhou

et al. 2024

Sci Rep

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“…miR-29a-3p has been recognized as a critical miRNA in various types of cancer, and typically functions as a tumor suppressor by directly targeting oncogenic genes ( 29 , 32 – 34 ). miR-29a-3p expression was shown to be downregulated in some cancer types, such as cervical ( 35 ), endometrial ( 13 ), and gastric ( 36 ) cancer, and this downregulation was associated with worse outcomes. Studies have reported that miR-29a-3p suppresses cell proliferation and migration in various types of cancer.…”

Section: Discussionmentioning

confidence: 99%

miR‑29a‑3p inhibits the malignant characteristics of non‑small cell lung cancer cells by reducing the activity of the Wnt/β‑catenin signaling pathway

Zhang

Han

et al. 2022

Oncol Lett

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MicroRNAs (miRNAs) can influence non-small cell lung cancer (NSCLC) in a tumor-suppressive and oncogenic manner. The present study aimed to investigate the effects and underlying mechanisms of miR-29a-3p in NSCLC. NSCLC cell lines (A549, H1299, and H460) and a normal lung epithelial cell line (BEAS-2B) were used. Additionally, a mouse lung tumor xenograft model was established using A549 cells and used to determine the effects of miR-29a-3p on NSCLC in vivo. Tumor volumes were measured every week. The expression of miR-29a-3p in cells and lung tissues were detected by RT-qPCR. Cell proliferation was detected using Cell Counting Kit-8 and EdU assays. Migration and invasion were assessed using wound healing and Transwell invasion assays, respectively. Ki-67 expression was detected using immunohistochemical staining. The expression levels of Wnt3a and β-catenin were determined using western blotting. miR-29a-3p expression was significantly downregulated in NSCLC cells and mice. In contrast to miR-29a-3p knockdown, miR-29a-3p overexpression decreased NSCLC cell proliferation, migration, and invasion as well as tumor growth in in the NSCLC mouse model. Moreover, miR-29a-3p overexpression decreased the protein expression levels of Wnt3a and β-catenin. The inhibitory effects of miR-29a-3p on NSCLC cells were reversed by LiCl (an activator of the Wnt signaling pathway). In conclusion, miR-29a-3p prevented NSCLC tumor growth and cell proliferation, migration, and invasion by inhibiting the Wnt/β-catenin signaling pathway. This finding offers novel insights into the prognosis and treatment of NSCLC.

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“…Meanwhile, the HOXA-AS3/miR-455-5p/PD-L1 [ 181 ] and miR-29c/ BMP1 [ 182 ] axis are implicated in the progression of HCC, as high expression of HOXA-AS3 leads to increased proliferation, metastasis, and invasion in HCC. In CC, HOXA-AS3 drives disease progression by modulating the activity of miR-29a-3p [ 183 ]. Furthermore, HOXA-AS3 interacts with HOXA3 to promote cisplatin resistance in NSCLC [ 80 ].…”

Section: Introductionmentioning

confidence: 99%

Role of HOXA1-4 in the development of genetic and malignant diseases

Wang,

Sun,

Cao

et al. 2024

Biomark Res

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The HOXA genes, belonging to the HOX family, encompass 11 members (HOXA1-11) and exert critical functions in early embryonic development, as well as various adult processes. Furthermore, dysregulation of HOXA genes is implicated in genetic diseases, heart disease, and various cancers. In this comprehensive overview, we primarily focused on the HOXA1-4 genes and their associated functions and diseases. Emphasis was placed on elucidating the impact of abnormal expression of these genes and highlighting their significance in maintaining optimal health and their involvement in the development of genetic and malignant diseases. Furthermore, we delved into their regulatory mechanisms, functional roles, and underlying biology and explored the therapeutic potential of targeting HOXA1-4 genes for the treatment of malignancies. Additionally, we explored the utility of HOXA1-4 genes as biomarkers for monitoring cancer recurrence and metastasis.

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Prognostic value of lncRNA HOXA‐AS3 in cervical cancer by targeting miR‐29a‐3p and its regulatory effect on tumor progression

Cited by 7 publications

References 33 publications

LncRNA HOXA-AS3 promotes cell proliferation and invasion via targeting miR-218-5p/FOXP1 axis in osteosarcoma

LncRNA HOXA-AS3 promotes cell proliferation and invasion via targeting miR-218-5p/FOXP1 axis in osteosarcoma

miR‑29a‑3p inhibits the malignant characteristics of non‑small cell lung cancer cells by reducing the activity of the Wnt/β‑catenin signaling pathway

Role of HOXA1-4 in the development of genetic and malignant diseases

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