Prognostic value of serial determinations of circulating immune complex levels in malignant melanoma

Bukh, Anne; Møller-Larsen, Anné; Aguado, M. Teresa; Møller-Larsen, F; Møller, Niels

doi:10.1007/bf00199942

Cited by 3 publications

(1 citation statement)

References 15 publications

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“…Circulating immune complexes (CIC) have been reported in the serum of patients with malignancies [60,61], but the occurrence of immune complex-mediated disease has been reported infrequently. The presence of CIC have been thought to indicate advanced stage or dissemination of disease [62], but in a recent prospective study, CIC were not found to be indicative of tumor recurrence in either melanoma or breast carcinoma [63]. Nephrotic syndrome secondary to CIC deposition has been reported in patients with non-Hodgkin's lymphoma.…”

Section: Immune Complex Diseasementioning

confidence: 99%

Rheumatologic manifestations of malignancy

Harris¹,

Thomas²,

Rest³

et al. 1990

Med. Pediatr. Oncol.

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The relationship between rheumatologic syndromes and cancer covers a very broad array of both common and distinctly rare manifestations. This discussion has outlined some of the known relationships that do exist. A high index of suspicion by both the primary care physician and subspecialist will enhance the probability of detecting cancer in the patient who may present with rheumatologic complaints.

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Section: Immune Complex Diseasementioning

confidence: 99%

Rheumatologic manifestations of malignancy

Harris¹,

Thomas²,

Rest³

et al. 1990

Med. Pediatr. Oncol.

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Human lung cancer—a comparative study of the levels of circulating immune complexes in pulmonary blood draining the tumor area and peripheral venous blood

Bukh

Kimose

Aguado

et al. 1989

Intl Journal of Cancer

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Our objective was to investigate whether low levels of circulating immune complexes (cICs) in peripheral venous blood of cancer patients could be due to removal of cIC released at the tumor site during passage to the peripheral veins. In 54 patients with primary lung cancer, we therefore compared the cIC levels as detected by 3 different assays in paired samples from the pulmonary vein draining the tumor area and from a peripheral vein. Only 6 of the 54 patients had significantly increased pulmonary vein cIC levels as compared to the corresponding peripheral vein levels. The peripheral vein levels of these 6 patients were all within the normal range, and in none of these patients was the difference between the 2 sites of analysis--although significant--of such a magnitude that the pulmonary vein cIC level appeared higher than the normal range, i.e., "positive" for cIC. Positive cIC levels were only found in 11% of lung cancer patients (irrespective of the site of measurement). Thus, our present data, together with our previous findings indicating no significant difference between peripheral venous blood cIC levels in cancer patients and normal controls, contradict the theory of tumor cells expressing new antigens resulting in the formation of tumor-associated cICs.

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