Serologic determinants of survival in patients with squamous cell carcinoma of the head and neck

Savage, Howard E.; Ainslie, Nancy; Liu, Frank J.; Schantz, Stimson P.

doi:10.1016/s0002-9610(05)80560-4

Cited by 6 publications

(2 citation statements)

References 14 publications

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“…In contrast, patients with residual lesions requiring ongoing chemotherapy showed persistently increased serum IgA levels. Schantz and colleagues reported an inverse association of pretreatment serum IgA with disease-free survival in patients with head and neck cancer (42), a finding that has also been supported by subsequent studies (50). These observations are also consistent with the results of a prospective cohort study in which high serum IgA associated with an increased mortality rate from solid cancer, but not with other common causes of death (51).…”

Section: Discussionsupporting

confidence: 63%

Association of Serum Immunoglobulin Levels with Solid Cancer: A Systematic Review and Meta-analysis

Peppas

George

Sollie

et al. 2020

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: The nature of humoral immunity in carcinogenesis remains poorly understood. In this systematic review and metaanalysis, we aimed to evaluate the association of serum immunoglobulin classes with solid cancer and test our hypothesis that the immune escape of tumors is accompanied by dysregulated systemic immunoglobulin class-switching.Methods: Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, we systematically searched the Cochrane Library, Embase, and MEDLINE/PubMed databases for observational studies investigating the association between serum immunoglobulins (IgA, IgG, and IgM) and histologically confirmed diagnosis of solid cancer in adults. We selected case-control studies, including more than 20 cases, and those explicitly stating that no form of anticancer treatment was administered prior to immunoglobulin measurement. No eligible cohort studies were identified. The primary summary measure was the standardized mean differ-ence (SMD) with 95% confidence intervals (CI) calculated using a random effects model.Results: Pooling 11 eligible studies comparing serum IgA levels in 1,351 patients and 560 control subjects revealed a statistically significant SMD (1.50; 95% CI, 0.96-2.04). Nonsignificant SMDs were observed for the 14 selected studies investigating serum IgG [SMD, À0.02 (95% CI, À0.22 to 0.18)] and for the 10 studies reporting serum IgM [SMD, 0.11 (95% CI, À0.10 to 0.32)]. Substantial heterogeneity between studies was observed despite sensitivity analysis by immunoglobulin measurement method, control matching, type of cancer, stage of disease, and sequential study exclusion.Conclusions: Serum immunoglobulin levels in patients diagnosed with solid cancer might be skewed toward class-switching to IgA, possibly reflecting Th2-polarized immunity.Impact: Further combinatorial analyses of serum immunoglobulin isotypes alongside other immune parameters in databases and observational studies are warranted.

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Section: Discussionsupporting

confidence: 63%

Association of Serum Immunoglobulin Levels with Solid Cancer: A Systematic Review and Meta-analysis

Peppas

George

Sollie

et al. 2020

Cancer Epidemiology, Biomarkers &Amp; Prevention

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“…The association between malnutrition and depressed immune function in cancer patients is well known [6]. In patients with head and neck cancer, functional alterations in polymorphonuclear leukocytes, lymphocytes, and monocytes have been documented [7-121. Changes in the number of cytotoxic T cells, natural killer cell activity, macrophage function, and the presence of immune complexes may contribute to a depressed antitumor immune response [8,[11][12][13]. It has been accepted that nutritional repletion, used as an adjunct to antineoplastic therapy, 0 1994 Wiley-Liss, Ine.…”

Section: Introductionmentioning

confidence: 99%

Nutritional support and prognosis in patients with head and neck cancer

López

Robinson

Madden

et al. 1994

Journal of Surgical Oncology

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We retrospectively studied the relationship between nutritional status as indicated by the presence or absence of the cutaneous delayed hypersensitivity response and treatment-related morbidity, disease recurrence, and survival at 2 years in 67 consecutive patients with head and neck carcinoma. Serial nutritional assessments were conducted throughout the course of combined initial antineoplastic treatment and nutritional support. The presence of cell-mediated immunity at the end of treatment was associated with a 2-year survival rate of 100%, whereas patients who were anergic at the end of treatment had a 2-year survival rate of 48% (P < 0.01). Morbidity due to surgical therapy and tumor recurrence rates were also higher in the anergic group (P < 0.01). Prognosis in head and neck cancer is based on many factors, but vigorous nutritional support during initial treatment may have some effect on morbidity, tumor recurrence, and survival time.

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Antibody to a mutagenic peptide of herpes simplex virus in young adult patients with cancer of the head and neck

Das

Schantz

Shillitoe

1993

Oral Surgery, Oral Medicine, Oral Pathology

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Serologic determinants of survival in patients with squamous cell carcinoma of the head and neck

Cited by 6 publications

References 14 publications

Association of Serum Immunoglobulin Levels with Solid Cancer: A Systematic Review and Meta-analysis

Association of Serum Immunoglobulin Levels with Solid Cancer: A Systematic Review and Meta-analysis

Nutritional support and prognosis in patients with head and neck cancer

Antibody to a mutagenic peptide of herpes simplex virus in young adult patients with cancer of the head and neck

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