Prognostic value of serum creatine level in patients with vulvar cancer

Abstract

Vulvar cancer is a rare malignancy with poor prognosis that generally occurs in elderly patients. The individual prognosis is difficult to assess. Serum creatinine levels are frequently elevated in elderly patients. Recent evidence have shown shown that - besides indicating kidney impairment - serum creatinine levels may be used to predict the survival in cancer patients. Several studies observed an association between elevated serum creatinine levels and poor prognosis in patients with solid tumors. In this retrospective cohort study, serum creatinine levels were evaluated in 170 patients with invasive vulvar cancer. Serum creatinine levels were correlated to established clinicopathologic factors. Univariate and multivariate survival analysis were performed. Elevated serum creatinine levels (>1.2 mg/dl) were significantly associated with both poor disease specific and overall survival. Three year overall survival rates were 74.8% and 32.5% for patients with serum creatinine levels of ≤ and >1.2 mg/dl, respectively. In a multivariate survival model, serum creatinine levels were significantly associated with overall survival independent of tumor stage and patients’ age. In conclusion, pretherapeutic serum creatinine levels may be useful as an independent prognostic parameter in patients with vulvar cancer.

Carotenoid-Enriched Fractions From Spondias mombin Demonstrate HER2 ATP Kinase Domain Inhibition: Computational and In Vivo Animal Model of Breast Carcinoma Studies

“…Reports of the existence of increased serum creatinine levels and poor prognosis in individuals with breast cancer have been established ( 29 ). The urea cycle increases nitrogen consumption in pyrimidine biosynthesis in cancer, and elevated urea concentration is connected to poor prognosis in neoplasm ( 30 ).…”

“…The re-docked pose reproduced the experimental pose; this shows that the docking scores obtained in this study are accurate. The kinase domain of HER2 exists in two structurally distinct states: active and inactive states (29). The active state is characterized by the presence of a salt bridge formed by two evolutionarily conserved amino acid residues K753 and E770.…”

“…The kinase domain of HER2 exists in two structurally distinct states: active and inactive states ( 29 ). The active state is characterized by the presence of a salt bridge formed by two evolutionarily conserved amino acid residues K753 and E770.…”

Dysregulation of serum electrolytes is detected in untreated cancer patients in Taif city

“…The creatine is utilized quickly by cancer cell as an energy resource so the creatinine level will be increased as a waste product. So when the level of creatine increased it could be associated with highly active tumor 16) . It is necessary to check the creatinine level before, during and after the chemotherapy to avoid any risk of kidney failure.…”

“…It is necessary to check the creatinine level before, during and after the chemotherapy to avoid any risk of kidney failure. Kidney function failure is particularly known as cardiovascular mortality 16) . Chloride usually secreted in the sweat, stomach and urine.…”