Prognostic value of serum pentraxin 3 for intracerebral hemorrhage mortality

Abstract

Pentraxin 3 is considered an important inflammatory marker is known to increase in patients with ischemic stroke, but the relationship between pentraxin 3 and intracerebral hemorrhage mortality is unclear. The purpose of this study is to investigate the level of pentraxin 3 in serum and its impact on prognosis in 307 patients with intracerebral hemorrhage. During the 5-year follow-up, the mortality rate of patients with intracerebral hemorrhage was 22.5%. The serum pentraxin 3 level of the brain-dead patients was higher than that of the control group (P < 0.05). Logistic regression analysis indicated a high correlation between the pentraxin 3 level and the mortality rate 95% (hazard ratio: 3.671; confidence interval: 1.558-4.297). The receiver operating characteristic curve showed that pentraxin 3 (Area Under Curve = 0.801) had a higher diagnostic value than C-reactive protein (Area Under Curve = 0.701). The pentraxin 3 level increased significantly after intracerebral hemorrhage and has an important predictive value for a prognosis for intracerebral hemorrhage mortality.

Blood-Based Biomarkers in Intracerebral Hemorrhage

“…In a study including 307 ICH patients, it was shown that pentraxin3 (blood samples were drawn within 24 h after ictus) tends to increase after symptom onset. Additionally, high levels of pentraxin3 in ICH patients were correlated with increased mortality during the 5-year follow-up period [61].…”